FR2248851A1 - Anti-inflammatory substance from blood - produced by gel filtration of serum or plasma - Google Patents
Anti-inflammatory substance from blood - produced by gel filtration of serum or plasmaInfo
- Publication number
- FR2248851A1 FR2248851A1 FR7435859A FR7435859A FR2248851A1 FR 2248851 A1 FR2248851 A1 FR 2248851A1 FR 7435859 A FR7435859 A FR 7435859A FR 7435859 A FR7435859 A FR 7435859A FR 2248851 A1 FR2248851 A1 FR 2248851A1
- Authority
- FR
- France
- Prior art keywords
- pref
- inflammatory
- prodt
- serum
- plasma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002260 anti-inflammatory agent Substances 0.000 title abstract 2
- 210000004369 blood Anatomy 0.000 title abstract 2
- 239000008280 blood Substances 0.000 title abstract 2
- 238000002523 gelfiltration Methods 0.000 title abstract 2
- 210000002966 serum Anatomy 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 2
- 102000004506 Blood Proteins Human genes 0.000 abstract 1
- 108010017384 Blood Proteins Proteins 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 abstract 1
- 229920002307 Dextran Polymers 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 abstract 1
- 208000025747 Rheumatic disease Diseases 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 235000010418 carrageenan Nutrition 0.000 abstract 1
- 229920001525 carrageenan Polymers 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 238000010828 elution Methods 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000000552 rheumatic effect Effects 0.000 abstract 1
- 238000000108 ultra-filtration Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
New anti-inflammatory matl. is produced by subjecting serum, plasma or a suitable fraction thereof to ultrafiltration followed by gel-filtration (pref. using a crosslinked dextran), then eluting from the gel a fraction displaying anti-inflammatory activity in the carrageenin rat-paw oedema test. The elution is pref. effected with an aq. medium of low ionic strength (pref. distilled water). The starting matl. is pref. obtd. from human or bovine blood. The prodt. should be substantially free from prodts. of mol.wt. >1,000. The prodt. is suitable for the treatment of rheumatic states and other inflammatory disorders. It is hypothesised that the prodt. is the natural 'protecting factor' which conventional anti-inflammatory agents displace from serum proteins.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB50037/73A GB1484131A (en) | 1973-10-26 | 1973-10-26 | Anti-inflammatory substances |
| GB3577874 | 1974-08-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2248851A1 true FR2248851A1 (en) | 1975-05-23 |
| FR2248851B1 FR2248851B1 (en) | 1978-07-28 |
Family
ID=26262856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7435859A Granted FR2248851A1 (en) | 1973-10-26 | 1974-10-25 | Anti-inflammatory substance from blood - produced by gel filtration of serum or plasma |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5082214A (en) |
| DE (1) | DE2450913A1 (en) |
| FR (1) | FR2248851A1 (en) |
| NL (1) | NL7413874A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3219248A1 (en) * | 1982-05-21 | 1983-11-24 | Solco Basel AG, Birsfelden | METHOD FOR OBTAINING CELL-BREATHING ACTIVE INGREDIENTS FROM CALF BLOOD |
| US4956349A (en) * | 1983-10-27 | 1990-09-11 | Stolle Research & Development Corporation | Anti-inflammatory factor, method of isolation, and use |
| CN112315863B (en) * | 2020-11-10 | 2021-12-03 | 山东百奥生物医药有限公司 | Composition for relieving pain and heat sensation in photoelectricity operation and preparation method and application thereof |
-
1974
- 1974-10-23 NL NL7413874A patent/NL7413874A/en not_active Application Discontinuation
- 1974-10-25 DE DE19742450913 patent/DE2450913A1/en active Pending
- 1974-10-25 FR FR7435859A patent/FR2248851A1/en active Granted
- 1974-10-26 JP JP49123857A patent/JPS5082214A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NL7413874A (en) | 1975-04-29 |
| FR2248851B1 (en) | 1978-07-28 |
| JPS5082214A (en) | 1975-07-03 |
| DE2450913A1 (en) | 1975-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |