FR2220269A1 - 3-Hydroxymethyl 5-phenyl 1,4-benzodiazepin-2-ones - with CNS depressant activity, e.g. sedative props. - Google Patents
3-Hydroxymethyl 5-phenyl 1,4-benzodiazepin-2-ones - with CNS depressant activity, e.g. sedative props.Info
- Publication number
- FR2220269A1 FR2220269A1 FR7407993A FR7407993A FR2220269A1 FR 2220269 A1 FR2220269 A1 FR 2220269A1 FR 7407993 A FR7407993 A FR 7407993A FR 7407993 A FR7407993 A FR 7407993A FR 2220269 A1 FR2220269 A1 FR 2220269A1
- Authority
- FR
- France
- Prior art keywords
- benzodiazepin
- sedative
- props
- hydroxymethyl
- ones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000000694 effects Effects 0.000 title abstract 2
- 239000000932 sedative agent Substances 0.000 title abstract 2
- 230000001624 sedative effect Effects 0.000 title abstract 2
- GYZRSXZAGUVLNV-UHFFFAOYSA-N 3-(hydroxymethyl)-5-phenyl-1,4-benzodiazepin-2-one Chemical class C=12C=CC=CC2=NC(=O)C(CO)=NC=1C1=CC=CC=C1 GYZRSXZAGUVLNV-UHFFFAOYSA-N 0.000 title 1
- 239000003874 central nervous system depressant Substances 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- -1 tranquillising Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2311714A DE2311714A1 (de) | 1973-03-09 | 1973-03-09 | Neue 1,4-benzodiazepine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2220269A1 true FR2220269A1 (en) | 1974-10-04 |
Family
ID=5874264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7407993A Withdrawn FR2220269A1 (en) | 1973-03-09 | 1974-03-08 | 3-Hydroxymethyl 5-phenyl 1,4-benzodiazepin-2-ones - with CNS depressant activity, e.g. sedative props. |
Country Status (13)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0167919A3 (en) * | 1984-06-26 | 1986-11-05 | Merck & Co. Inc. | Benzodiazepine derivatives and pharmaceutical compositions containing them |
| US4820834A (en) * | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
-
1973
- 1973-03-09 DE DE2311714A patent/DE2311714A1/de active Pending
-
1974
- 1974-02-05 NL NL7401546A patent/NL7401546A/xx unknown
- 1974-02-13 AT AT112574A patent/AT347860B/de not_active IP Right Cessation
- 1974-02-14 ES ES423226A patent/ES423226A1/es not_active Expired
- 1974-03-06 RO RO7400077932A patent/RO63578A/ro unknown
- 1974-03-07 JP JP49026747A patent/JPS49125383A/ja active Pending
- 1974-03-07 IL IL44366A patent/IL44366A0/xx unknown
- 1974-03-07 AU AU66416/74A patent/AU6641674A/en not_active Expired
- 1974-03-07 DD DD177031A patent/DD112264A5/xx unknown
- 1974-03-07 HU HUTO955A patent/HU166787B/hu unknown
- 1974-03-08 BE BE141829A patent/BE812087A/xx unknown
- 1974-03-08 SE SE7403160A patent/SE7403160L/xx not_active Application Discontinuation
- 1974-03-08 FR FR7407993A patent/FR2220269A1/fr not_active Withdrawn
- 1974-06-04 ES ES426948A patent/ES426948A1/es not_active Expired
- 1974-06-04 ES ES426949A patent/ES426949A1/es not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0167919A3 (en) * | 1984-06-26 | 1986-11-05 | Merck & Co. Inc. | Benzodiazepine derivatives and pharmaceutical compositions containing them |
| US4820834A (en) * | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
| EP0284256B1 (en) * | 1987-03-16 | 1994-06-01 | Merck & Co. Inc. | Benzodiazepine analogs |
Also Published As
| Publication number | Publication date |
|---|---|
| ES426948A1 (es) | 1976-07-16 |
| RO63578A (fr) | 1978-08-15 |
| AT347860B (de) | 1979-01-25 |
| NL7401546A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-09-11 |
| BE812087A (fr) | 1974-09-09 |
| SE7403160L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-09-10 |
| DD112264A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-04-05 |
| IL44366A0 (en) | 1974-06-30 |
| AU6641674A (en) | 1975-09-11 |
| ES423226A1 (es) | 1976-05-01 |
| HU166787B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-05-28 |
| ES426949A1 (es) | 1976-07-16 |
| DE2311714A1 (de) | 1974-09-19 |
| ATA112574A (de) | 1978-05-15 |
| JPS49125383A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-11-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR2181559A1 (en) | N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity | |
| ES8800937A1 (es) | Un procedimiento para la obtencion de derivados de bi- y triciclicos de piridona | |
| FR2220269A1 (en) | 3-Hydroxymethyl 5-phenyl 1,4-benzodiazepin-2-ones - with CNS depressant activity, e.g. sedative props. | |
| ES418891A1 (es) | Procedimiento para la obtencion de compuestos de acil-hi- drazona. | |
| FR2116302A1 (en) | 8-aminotheophyllines - with coronary - vasodilator bronchodilator diuretic, spasmolytic, antiinflammatory and analgesic activity | |
| SU1568887A3 (ru) | Cпocoб пoлучehия пипepaзиhcoдepжaщиx углeboдopoдob или иx kиcлotho-aддиtиbhыx coлeй | |
| FR2047882A1 (en) | Analgesic antiinflammatory 4-(2-alkoxy - phenylamino-quinolines and intermediates | |
| ES418996A1 (es) | Un procedimiento para la preparacion de derivados de piri- midina biologicamente activos. | |
| FR2236862A1 (en) | 2-Anilino-nicotinic acids - as analgesic antiinflammatory and antipyretic agents | |
| BE810067R (fr) | N0uveaux derives de alpha-dialkylaminoalkoxy-6 dimethoxy-4 | |
| ES385924A1 (es) | Procedimiento para la preparacion de nuevos derivados de benzodiaxonano. | |
| IT1044824B (it) | Derivati 3 2 benzossazepinici | |
| ES394409A1 (es) | Un procedimiento para la preparacion de derivados de 5n-o- xido de triazolbenzodiazepina. | |
| FR2130361A1 (en) | 3,2-benzoxazepines - useful as antiinflammatory sedative anxiolytic,myorelaxing and hypnotic agents | |
| ES426771A1 (es) | Procedimiento para preparar derivados aminopropanolicos. | |
| ES423024A1 (es) | Procedimiento para la preparacion de derivados de acidos penicilanico y cefalosporanico. | |
| AR207960A1 (es) | Procedimiento para preparar un acido 7-(acetamido-2-sustituido)-3-cefem-4-carboxilico y sus sales | |
| FR2073286A1 (en) | Substd anilines - with antirheumatic analgesic and antiinflammatory activity | |
| FR2173172A1 (en) | 5-carbamoyl-iminodibenzyls and iminostilbenes prepn - with anticonvulsant, muscle relaxant and sedative-tranquillizing props | |
| FR2208654A2 (en) | Heterocyclic esters of 5,5-dialkyl-8-substd 1,2,3,4-tetrahydro - -5h-(1)-benzopyrano(3,4-d)-pyridin-10-ols - with analgesic and mild | |
| FR2131869A1 (en) | Piperidine-2,6-diones - with sedative, hypnotic and antiepileptic activity | |
| FR2100909A1 (fr) | Amides de l'acide indazole-3-carboxylique et procedes de preparation | |
| FR2124066A1 (en) | Alpha-piperazino-beta-benzoylpropionic acids - - with analgesic,analeptic,anticonvulsant and other activity | |
| FR2166021A1 (en) | Heterocyclic esters of 5,5-dialkyl-8-substd 1,2,3,4-tetrahydro - -5h-(1)-benzopyrano(3,4-d)-pyridin-10-ols - with analgesic and mild | |
| FR2228480A1 (en) | 1-Phenoxy-3-amino-prop-2-yl esters - of 4-chloro-phenoxyisobutyric acid with analgesic and sympatholytic activity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |