FR2209747A1 - Amide protection and de-protection - without racemisation of products esp peptides hormones,antibiotics - Google Patents

Amide protection and de-protection - without racemisation of products esp peptides hormones,antibiotics

Info

Publication number
FR2209747A1
FR2209747A1 FR7343441A FR7343441A FR2209747A1 FR 2209747 A1 FR2209747 A1 FR 2209747A1 FR 7343441 A FR7343441 A FR 7343441A FR 7343441 A FR7343441 A FR 7343441A FR 2209747 A1 FR2209747 A1 FR 2209747A1
Authority
FR
France
Prior art keywords
protection
racemisation
antibiotics
amide
substd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7343441A
Other languages
French (fr)
Other versions
FR2209747B3 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of FR2209747A1 publication Critical patent/FR2209747A1/en
Application granted granted Critical
Publication of FR2209747B3 publication Critical patent/FR2209747B3/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic System

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Title amides (I) are prepd by reacting protected products (II) with acid at -40 to +50 degrees C: R1CONHR2 (I) R1-CON-R2 (where R1 and R2 are h, opt. substd or aryl; R3 is an opt. substd aromatic radical and R4 is alkyl, cycloalkyl or opt. substd aryl). Acids are org. or mineral e.g. TFA, or methanolic HCl.
FR7343441A 1972-12-06 1973-12-05 Amide protection and de-protection - without racemisation of products esp peptides hormones,antibiotics Granted FR2209747A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19722259567 DE2259567A1 (en) 1972-12-06 1972-12-06 METHOD FOR PRODUCING AMIDES

Publications (2)

Publication Number Publication Date
FR2209747A1 true FR2209747A1 (en) 1974-07-05
FR2209747B3 FR2209747B3 (en) 1976-10-15

Family

ID=5863611

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7343441A Granted FR2209747A1 (en) 1972-12-06 1973-12-05 Amide protection and de-protection - without racemisation of products esp peptides hormones,antibiotics

Country Status (4)

Country Link
JP (1) JPS49100017A (en)
BE (1) BE808291A (en)
DE (1) DE2259567A1 (en)
FR (1) FR2209747A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103201263A (en) 2010-09-08 2013-07-10 匹兹堡高等教育联邦体系大学 P53-Mdm2 antagonists
KR101861869B1 (en) * 2013-09-10 2018-05-28 경희대학교 산학협력단 A novel bis-amide derivatives and use thereof

Also Published As

Publication number Publication date
BE808291A (en) 1974-06-06
DE2259567A1 (en) 1974-06-20
FR2209747B3 (en) 1976-10-15
JPS49100017A (en) 1974-09-20

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Legal Events

Date Code Title Description
ST Notification of lapse