CH503697A - Amino acid esters - Google Patents

Amino acid esters

Info

Publication number
CH503697A
CH503697A CH1283267A CH1283267A CH503697A CH 503697 A CH503697 A CH 503697A CH 1283267 A CH1283267 A CH 1283267A CH 1283267 A CH1283267 A CH 1283267A CH 503697 A CH503697 A CH 503697A
Authority
CH
Switzerland
Prior art keywords
esters
amino acid
active
acid
hydroxamic
Prior art date
Application number
CH1283267A
Other languages
German (de)
Inventor
Taszner Emil
Lubniewska Lucja
Rzeszotarska Barbara
Original Assignee
Jeleniogorsk Z Farma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PL116448A external-priority patent/PL60695B1/pl
Application filed by Jeleniogorsk Z Farma filed Critical Jeleniogorsk Z Farma
Publication of CH503697A publication Critical patent/CH503697A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

(A) (B) (I) + H2NR" R-CO-NH-R"+R-CO-NH-OH R = aryl R' = N-protected amino acid or peptide R' = aliphatic or amino acid derivs. The esters formed are optically active and may be used for the direct prepn. of the amide- or peptide bonding without isolation of the active hydroxamic esters and without loss of configuration. The new method gives active esters which retain their configuration. The catalysis B gives better yields and products with greater purity. The active esters are formed by reacting acid chlorides, opt. symmetrical anhydrides or acid activated with dicyclohexyldiimide, with hydroxamic acid or a salt. The esters are obtained by the reaction of hydroxamic acid chlorides with tert.
CH1283267A 1966-09-13 1967-09-13 Amino acid esters CH503697A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL116448A PL60695B1 (en) 1966-09-13

Publications (1)

Publication Number Publication Date
CH503697A true CH503697A (en) 1971-02-28

Family

ID=19949525

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1283267A CH503697A (en) 1966-09-13 1967-09-13 Amino acid esters

Country Status (4)

Country Link
CH (1) CH503697A (en)
DE (1) DE1643422A1 (en)
GB (1) GB1195736A (en)
NL (1) NL6712522A (en)

Also Published As

Publication number Publication date
NL6712522A (en) 1968-03-14
DE1643422A1 (en) 1972-03-30
GB1195736A (en) 1970-06-24

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Legal Events

Date Code Title Description
PL Patent ceased