FR2176561A2 - 4'-n-tert-amino-methyl-2'-(dibenzo (b,e) oxepine-11-spiro) - 1',3'-dioxolan - analgesic, respiratory analeptic, antitussive, broch - Google Patents
4'-n-tert-amino-methyl-2'-(dibenzo (b,e) oxepine-11-spiro) - 1',3'-dioxolan - analgesic, respiratory analeptic, antitussive, brochInfo
- Publication number
- FR2176561A2 FR2176561A2 FR7210250A FR7210250A FR2176561A2 FR 2176561 A2 FR2176561 A2 FR 2176561A2 FR 7210250 A FR7210250 A FR 7210250A FR 7210250 A FR7210250 A FR 7210250A FR 2176561 A2 FR2176561 A2 FR 2176561A2
- Authority
- FR
- France
- Prior art keywords
- amino
- broch
- oxepine
- antitussive
- dioxolan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7210250A FR2176561A2 (en) | 1972-03-23 | 1972-03-23 | 4'-n-tert-amino-methyl-2'-(dibenzo (b,e) oxepine-11-spiro) - 1',3'-dioxolan - analgesic, respiratory analeptic, antitussive, broch |
BE783499A BE783499A (fr) | 1971-05-28 | 1972-05-15 | N-tertiaire aminomethyl-4' dibenzo (b,e) oxepine-11-spiro- 2'-dioxolanne-1',3', leur procede de preparation et leur application en therapeutique |
LU65380A LU65380A1 (fr) | 1971-05-28 | 1972-05-17 | |
GB2391572A GB1359951A (en) | 1971-05-28 | 1972-05-22 | Ny-tertiary-4,-aminomethyl-dibenzo-b,e-11-oxepine-2,-spiro- 1,3,-dioxolanes their process of preparation and their thera peutic application |
IL39496A IL39496A (en) | 1971-05-28 | 1972-05-22 | Dibenzo(b,e)oxepine spiro dioxolane derivatives,their preparation and pharmaceutical compositions containing them |
CH757472A CH532034A (fr) | 1971-05-28 | 1972-05-23 | Procédé de préparation de dibenzo-oxépine-spiro-dioxolannes substiués |
DE2225245A DE2225245C3 (de) | 1971-05-28 | 1972-05-24 | (b,e)-Dibenzoxepin-ll-spiro-2'-0'3'-dioxolan)-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
US00256655A US3845046A (en) | 1971-05-28 | 1972-05-25 | N-tertiary-4-aminomethyl-dibenzo(b,e)-11-oxepine-2'-spiro-1',3'-dioxolanes |
AU42788/72A AU465949B2 (en) | 1971-03-28 | 1972-05-26 | N-TERTIARY-4'-AMINOMETHYL-DIBENZO b,e-11-OXEPINE-2'-SPIRO-1',3'-DIOXOLANES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTIC APPLICATION |
CA143,363A CA989404A (fr) | 1971-05-28 | 1972-05-26 | N-tertiaire aminomethyl-4' dibenzo(b,e)oxepine-11 spiro-2'-dioxolanne-1',3', leur procede de preparation et leur application en therapeutique |
SU1788862A SU420174A3 (ru) | 1971-05-28 | 1972-05-26 | СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ СПИРО (ДИБЕНЗО /Ь, е/ ОКСЕПИН-]1:2'-/4' АМИНОМЕТИЛДИОКСОЛАНА-]', 34}1Изобретение относнтс к способу нолуче- ни новых соединений — производных спиро (Д'ибензо/Ь, е/ оксеп1ш-11:'2'-/4'-а'Минометил- Д|ИО:Ксолана-Г, 3'/) формулы I' 'оЛь' ^°LJ_5' Ц^СНг-NRRIгексамет'илен.]1ми11овый радикал; -или их солей.Эти соединени обладают ценными физиологически активиыми свойствами. 5 Способ основан на реакции получени 4- амН'Нометилдиоксолана- 1,3 2-спи1ранового р да взаимодействием циклокетонов с э-пибром- гидр«но.м и последующим вза!И!Модейств)1ем Образующегос 4-бромметилдлоксолаиа-1,3 10 2-СПиранового р да с-а^минами.Предлагаемый способ заключаетс и том, что дибензо /Ь, е/ оксепин-11-он фор.мулы IIгде Z — атом водорода или галогена или ал- кокоигруп'па с 1—4 атомами углерода и R и Ri — ал'К'ИЛ с 1—3 атомами углерода или группы R 1И RI вместе с ато.мом азота, с которым ои)[ св заны, образуют пирролидиновое, иипери- ди^новое 1ИЛ'И -морфолииовое кольцо, гексамс- Т|Илен'ИМ;ин ил'И штераз.иновое кольцо, незз- мещенное юи N'-3aMeuieHHoe алкилом с 1—3 атомами углерода, который люжет быть мо- но-!или Д1И-замещен гидроксильной груипой, или пинеразиновое кольцо, N'-3aMemeHnoe аминокарбонил'метильиой группой, в которой атом азота может быть моно-или ди-заме- щеп алкило.м с 1—3 атомами углерода «ливходит -в ПИррОЛЛДИИОВЫЙ, МОРФОЛИНОВЫЙ ИЛ'Игде Z и.меет указа]П1ые значени , подвергают взаимодействию сэпибромгидрииом, образующийс спиро (дибеизо /Ь, е/ о«селнн-М:2'-/4'- бром1метилдиоксола11-1', 3'/) подвергают взаимодействию с вторичным амином формулы HIH-NX30к^R, |
SE7206954A SE373583B (sv) | 1971-05-28 | 1972-05-26 | Sett att framstella 4' -n- tertieramino-metyl-2', 11-spirodibenso b,e oxepin-1',3'- dioxolaner |
CS7200003650A CS181224B2 (en) | 1971-05-28 | 1972-05-26 | Method of production of 4-/n-tertiary aminomethyl/-2-/dibenzo/b,c/oxepine-11-spiro/-1,3-dioxolanes |
AR242209A AR192786A1 (es) | 1971-05-28 | 1972-05-26 | Procedimiento para la preparacion de nuevos n-amina-terciaria-metil-4'dibenzo(b,e)oxepina-11-espiro-2'dioxolanos-1',3' |
IT68696/72A IT1052682B (it) | 1971-05-28 | 1972-05-27 | N terziario amminometil 4 dibenzo b.e, oxepina 11 spiro 2 diossola no 1, 3, loro procedimento di preparazione e loro applicazione interapia |
JP47052583A JPS5218196B1 (fr) | 1971-05-28 | 1972-05-29 | |
NL7207229A NL7207229A (fr) | 1971-05-28 | 1972-05-29 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7210250A FR2176561A2 (en) | 1972-03-23 | 1972-03-23 | 4'-n-tert-amino-methyl-2'-(dibenzo (b,e) oxepine-11-spiro) - 1',3'-dioxolan - analgesic, respiratory analeptic, antitussive, broch |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2176561A2 true FR2176561A2 (en) | 1973-11-02 |
FR2176561B2 FR2176561B2 (fr) | 1975-04-25 |
Family
ID=9095707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7210250A Granted FR2176561A2 (en) | 1971-03-28 | 1972-03-23 | 4'-n-tert-amino-methyl-2'-(dibenzo (b,e) oxepine-11-spiro) - 1',3'-dioxolan - analgesic, respiratory analeptic, antitussive, broch |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2176561A2 (fr) |
-
1972
- 1972-03-23 FR FR7210250A patent/FR2176561A2/fr active Granted
Also Published As
Publication number | Publication date |
---|---|
FR2176561B2 (fr) | 1975-04-25 |
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