CA989404A - N-tertiaire aminomethyl-4' dibenzo(b,e)oxepine-11 spiro-2'-dioxolanne-1',3', leur procede de preparation et leur application en therapeutique - Google Patents

N-tertiaire aminomethyl-4' dibenzo(b,e)oxepine-11 spiro-2'-dioxolanne-1',3', leur procede de preparation et leur application en therapeutique

Info

Publication number
CA989404A
CA989404A CA143,363A CA143363A CA989404A CA 989404 A CA989404 A CA 989404A CA 143363 A CA143363 A CA 143363A CA 989404 A CA989404 A CA 989404A
Authority
CA
Canada
Prior art keywords
dioxolanne
oxepine
dibenzo
spiro
preparation process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA143,363A
Other languages
English (en)
Other versions
CA143363S (en
Inventor
Claude Fauran
Guy Raynaud
Jeannine Eberle
Albert-Yves Le Cloarec
Bernard Pourrias
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7119501A external-priority patent/FR2139651A1/fr
Priority claimed from FR7210250A external-priority patent/FR2176561A2/fr
Application filed by Delalande SA filed Critical Delalande SA
Application granted granted Critical
Publication of CA989404A publication Critical patent/CA989404A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
CA143,363A 1971-05-28 1972-05-26 N-tertiaire aminomethyl-4' dibenzo(b,e)oxepine-11 spiro-2'-dioxolanne-1',3', leur procede de preparation et leur application en therapeutique Expired CA989404A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7119501A FR2139651A1 (en) 1971-05-28 1971-05-28 4'-n-tert-amino-methyl-2'-(dibenzo (b,e) oxepine-11-spiro) - 1',3'-dioxolan - analgesic, respiratory analeptic, antitussive, broch
FR7210250A FR2176561A2 (en) 1972-03-23 1972-03-23 4'-n-tert-amino-methyl-2'-(dibenzo (b,e) oxepine-11-spiro) - 1',3'-dioxolan - analgesic, respiratory analeptic, antitussive, broch

Publications (1)

Publication Number Publication Date
CA989404A true CA989404A (fr) 1976-05-18

Family

ID=26216420

Family Applications (1)

Application Number Title Priority Date Filing Date
CA143,363A Expired CA989404A (fr) 1971-05-28 1972-05-26 N-tertiaire aminomethyl-4' dibenzo(b,e)oxepine-11 spiro-2'-dioxolanne-1',3', leur procede de preparation et leur application en therapeutique

Country Status (16)

Country Link
US (1) US3845046A (fr)
JP (1) JPS5218196B1 (fr)
AR (1) AR192786A1 (fr)
AU (1) AU465949B2 (fr)
BE (1) BE783499A (fr)
CA (1) CA989404A (fr)
CH (1) CH532034A (fr)
CS (1) CS181224B2 (fr)
DE (1) DE2225245C3 (fr)
GB (1) GB1359951A (fr)
IL (1) IL39496A (fr)
IT (1) IT1052682B (fr)
LU (1) LU65380A1 (fr)
NL (1) NL7207229A (fr)
SE (1) SE373583B (fr)
SU (1) SU420174A3 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4048164A (en) * 1971-06-18 1977-09-13 Delalande S.A. N'-substituted derivatives of 4'-(N-piperazinylmethyl)spiro dibenzocycloheptadi- (or tri-) ene-5,2'-dioxolane(1',3')
EP0295209A3 (fr) * 1987-06-10 1990-01-24 Ciba-Geigy Ag Esters d'acide orthocarbonique
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
WO1998046628A1 (fr) * 1997-04-14 1998-10-22 Cor Therapeutics, Inc. INHIBITEURS SELECTIFS DU FACTEUR Xa
NZ500353A (en) 1997-04-14 2002-02-01 Cor Therapeutics Inc Cyclic diaza compounds that are selective inhibitors of factor Xa
CA2285659A1 (fr) 1997-04-14 1998-10-22 Cor Therapeutics, Inc. Inhibiteurs selectifs du facteur xa
EP0975625A1 (fr) * 1997-04-14 2000-02-02 Cor Therapeutics, Inc. INHIBITEURS SELECTIFS DU FACTEUR Xa
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
CA2520680A1 (fr) * 2003-03-31 2004-10-14 Kyowa Hakko Kogyo Co., Ltd. Antitussifs

Also Published As

Publication number Publication date
US3845046A (en) 1974-10-29
SU420174A3 (ru) 1974-03-15
IT1052682B (it) 1981-07-20
SE373583B (sv) 1975-02-10
BE783499A (fr) 1972-11-16
LU65380A1 (fr) 1973-01-22
CS181224B2 (en) 1978-03-31
IL39496A (en) 1975-04-25
DE2225245B2 (de) 1978-03-02
JPS5218196B1 (fr) 1977-05-20
AU4278872A (en) 1973-11-29
DE2225245C3 (de) 1978-11-02
DE2225245A1 (de) 1973-01-04
GB1359951A (en) 1974-07-17
NL7207229A (fr) 1972-11-30
AU465949B2 (en) 1975-10-09
AR192786A1 (es) 1973-03-14
CH532034A (fr) 1972-12-31
IL39496A0 (en) 1972-07-26

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