FR2176509A2 - Pyridoxine p-chlorophenoxyisobutyrate prodn - giving very pure product from corresp acid and pyridoxine - Google Patents

Pyridoxine p-chlorophenoxyisobutyrate prodn - giving very pure product from corresp acid and pyridoxine

Info

Publication number
FR2176509A2
FR2176509A2 FR7209868A FR7209868A FR2176509A2 FR 2176509 A2 FR2176509 A2 FR 2176509A2 FR 7209868 A FR7209868 A FR 7209868A FR 7209868 A FR7209868 A FR 7209868A FR 2176509 A2 FR2176509 A2 FR 2176509A2
Authority
FR
France
Prior art keywords
pyridoxine
chlorophenoxyisobutyrate
prodn
acid
corresp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7209868A
Other languages
French (fr)
Other versions
FR2176509B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST RECH SCIENT
Original Assignee
INST RECH SCIENT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST RECH SCIENT filed Critical INST RECH SCIENT
Priority to FR7209868A priority Critical patent/FR2176509A2/en
Priority to BE2052585A priority patent/BE796592R/en
Priority to SE7303788A priority patent/SE383343B/en
Priority to DE19732313891 priority patent/DE2313891A1/en
Publication of FR2176509A2 publication Critical patent/FR2176509A2/en
Application granted granted Critical
Publication of FR2176509B2 publication Critical patent/FR2176509B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine

Abstract

The title cpd which is a pharmaceutical is prepd. by preparing separately an aq. soln. contg. anhydrous Na2CO3 and p-chlorophenoxyisobutyric acid, and an aq. soln. of pyridoxine, HCl, pouring the two solns simultaneously into a reactor fitted with a stirrer which contains a soln. of pyridoxine p-chlorophenoxyisobutyrate to act as a crystallisation initiator cooling and sepg. the crystals which are then submitted to a final heat treatment. This process avoids the prodn. of an oily phase on mixing of the solns.
FR7209868A 1972-03-21 1972-03-21 Pyridoxine p-chlorophenoxyisobutyrate prodn - giving very pure product from corresp acid and pyridoxine Granted FR2176509A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR7209868A FR2176509A2 (en) 1972-03-21 1972-03-21 Pyridoxine p-chlorophenoxyisobutyrate prodn - giving very pure product from corresp acid and pyridoxine
BE2052585A BE796592R (en) 1972-03-21 1973-03-12 PYRIDOXINE P-CHLOROPHENOXYISOBUTYRATE MEDICINAL PRODUCT
SE7303788A SE383343B (en) 1972-03-21 1973-03-19 PROCEDURE FOR THE PREPARATION OF PARACLORPHENOXYISOBUTYRATE OF PYRIDOXIN IN PURE FORM
DE19732313891 DE2313891A1 (en) 1972-03-21 1973-03-20 PROCESS FOR THE PRODUCTION OF PYRIDOXINP-CHLOROPHENOXYISOBUTYRATE AS THE ACTIVE SUBSTANCE OF A MEDICINAL PRODUCT

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7209868A FR2176509A2 (en) 1972-03-21 1972-03-21 Pyridoxine p-chlorophenoxyisobutyrate prodn - giving very pure product from corresp acid and pyridoxine

Publications (2)

Publication Number Publication Date
FR2176509A2 true FR2176509A2 (en) 1973-11-02
FR2176509B2 FR2176509B2 (en) 1976-07-02

Family

ID=9095580

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7209868A Granted FR2176509A2 (en) 1972-03-21 1972-03-21 Pyridoxine p-chlorophenoxyisobutyrate prodn - giving very pure product from corresp acid and pyridoxine

Country Status (4)

Country Link
BE (1) BE796592R (en)
DE (1) DE2313891A1 (en)
FR (1) FR2176509A2 (en)
SE (1) SE383343B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3705549A1 (en) * 1987-02-18 1988-09-01 Ulrich Speck USE OF PYRIDOXINE DERIVATIVES IN THE PROPHYLAXIS AND THERAPY OF HYPERLIPIDAEMIA AND ATHEROSCLEROSIS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Also Published As

Publication number Publication date
DE2313891A1 (en) 1973-10-04
SE383343B (en) 1976-03-08
BE796592R (en) 1973-07-02
FR2176509B2 (en) 1976-07-02

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