GB1469921A - Industrial processes for the synthesis of 2,6-dibromocineole and 2,6-dihydroxycineole products thus obtained and use thereof in the pharmaceutical field - Google Patents

Industrial processes for the synthesis of 2,6-dibromocineole and 2,6-dihydroxycineole products thus obtained and use thereof in the pharmaceutical field

Info

Publication number
GB1469921A
GB1469921A GB4347676A GB4347676A GB1469921A GB 1469921 A GB1469921 A GB 1469921A GB 4347676 A GB4347676 A GB 4347676A GB 4347676 A GB4347676 A GB 4347676A GB 1469921 A GB1469921 A GB 1469921A
Authority
GB
United Kingdom
Prior art keywords
dihydroxycineole
cineole
dibromo
dibromocineole
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4347676A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CORVI SpA
Original Assignee
CORVI SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CORVI SpA filed Critical CORVI SpA
Publication of GB1469921A publication Critical patent/GB1469921A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Abstract

1469921 Preparation of 2,6 - dibromo- and 2,6-dihydroxy-cineole CAMILLO CORVI SpA 30 May 1974 [12 June 1973 10 April 1974] 43476/76 Divided out of 1468758 Heading C2C 2,6-Dibromo-cineole is prepared by treating very pure sobrerol with a mineral or organic acid and brominating the very pure pinol formed. The 2,6-dibromo-cineole may be treated with sodium acetate and acetic acid to give 2,6-dihydroxycineole acetate which may then be hydrolysed to give 2,6-dihydroxycineole. The reactions are illustrated in the following sequence Pharmaceutical compositions having choleretic activity comprise the 2,6-dibromo- or 2,6- dihydroxy-cineole, when prepared by the above processes, together with a suitable carrier or diluent.
GB4347676A 1973-06-12 1974-05-30 Industrial processes for the synthesis of 2,6-dibromocineole and 2,6-dihydroxycineole products thus obtained and use thereof in the pharmaceutical field Expired GB1469921A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2512773 1973-06-12
IT2120574 1974-04-10

Publications (1)

Publication Number Publication Date
GB1469921A true GB1469921A (en) 1977-04-06

Family

ID=26327823

Family Applications (2)

Application Number Title Priority Date Filing Date
GB2409074A Expired GB1468758A (en) 1973-06-12 1974-05-30 Industrial process for the synthesis of 2,6-dihydroxy-cineole through pinol from highly pure sobrerol products thus obtained and use thereof in pharmaceutical field
GB4347676A Expired GB1469921A (en) 1973-06-12 1974-05-30 Industrial processes for the synthesis of 2,6-dibromocineole and 2,6-dihydroxycineole products thus obtained and use thereof in the pharmaceutical field

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB2409074A Expired GB1468758A (en) 1973-06-12 1974-05-30 Industrial process for the synthesis of 2,6-dihydroxy-cineole through pinol from highly pure sobrerol products thus obtained and use thereof in pharmaceutical field

Country Status (7)

Country Link
JP (1) JPS5944316B2 (en)
AR (2) AR202410A1 (en)
CH (1) CH605965A5 (en)
DE (2) DE2428039C3 (en)
ES (1) ES427240A1 (en)
GB (2) GB1468758A (en)
NL (3) NL176745C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4542244A (en) * 1982-09-13 1985-09-17 Shell Oil Company Oxabicycloalkane herbicides

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554366A (en) * 1982-09-13 1985-11-19 Shell Oil Company Certain substituted, 7-oxabicyclo[2.2.1]heptan-2-ols and -2-ones as intermediates
JPS61181403A (en) * 1985-02-06 1986-08-14 島村　▲てい▼次郎 Stick

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4542244A (en) * 1982-09-13 1985-09-17 Shell Oil Company Oxabicycloalkane herbicides

Also Published As

Publication number Publication date
JPS5035155A (en) 1975-04-03
DE2428039A1 (en) 1975-01-09
DE2462947C2 (en) 1986-08-28
DE2428039B2 (en) 1980-10-30
NL8403477A (en) 1985-03-01
DE2428039C3 (en) 1981-12-24
NL7407862A (en) 1974-12-16
AR202410A1 (en) 1975-06-06
ES427240A1 (en) 1976-09-01
GB1468758A (en) 1977-03-30
NL176745B (en) 1985-01-02
NL8403481A (en) 1985-03-01
JPS5944316B2 (en) 1984-10-29
AR202506A1 (en) 1975-06-13
CH605965A5 (en) 1978-10-13
NL176745C (en) 1985-06-03

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee