FR2172868A1 - Carboxy substd benzophenone derivs - as analgesics and antiinflammatory agents - Google Patents
Carboxy substd benzophenone derivs - as analgesics and antiinflammatory agentsInfo
- Publication number
- FR2172868A1 FR2172868A1 FR7206402A FR7206402A FR2172868A1 FR 2172868 A1 FR2172868 A1 FR 2172868A1 FR 7206402 A FR7206402 A FR 7206402A FR 7206402 A FR7206402 A FR 7206402A FR 2172868 A1 FR2172868 A1 FR 2172868A1
- Authority
- FR
- France
- Prior art keywords
- acid
- alkyl
- substd
- cmpds
- dicarboxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000730 antalgic agent Substances 0.000 title abstract 2
- 239000002260 anti-inflammatory agent Substances 0.000 title abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 title abstract 2
- 229940035676 analgesics Drugs 0.000 title 1
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 title 1
- 239000012965 benzophenone Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 3
- NRPFNQUDKRYCNX-UHFFFAOYSA-N 4-methoxyphenylacetic acid Chemical compound COC1=CC=C(CC(O)=O)C=C1 NRPFNQUDKRYCNX-UHFFFAOYSA-N 0.000 abstract 2
- 230000010933 acylation Effects 0.000 abstract 2
- 238000005917 acylation reaction Methods 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- OTKCEEWUXHVZQI-UHFFFAOYSA-N 1,2-diphenylethanone Chemical compound C=1C=CC=CC=1C(=O)CC1=CC=CC=C1 OTKCEEWUXHVZQI-UHFFFAOYSA-N 0.000 abstract 1
- YFKBXYGUSOXJGS-UHFFFAOYSA-N 1,3-Diphenyl-2-propanone Chemical compound C=1C=CC=CC=1CC(=O)CC1=CC=CC=C1 YFKBXYGUSOXJGS-UHFFFAOYSA-N 0.000 abstract 1
- VVWPIDREBNSELC-UHFFFAOYSA-N 2-(3,4-dimethylbenzoyl)-6-methylbenzoic acid Chemical compound CC=1C=C(C(=O)C2=C(C(=CC=C2)C)C(=O)O)C=CC1C VVWPIDREBNSELC-UHFFFAOYSA-N 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- VMZCDNSFRSVYKQ-UHFFFAOYSA-N 2-phenylacetyl chloride Chemical compound ClC(=O)CC1=CC=CC=C1 VMZCDNSFRSVYKQ-UHFFFAOYSA-N 0.000 abstract 1
- AKHSBAVQPIRVAG-UHFFFAOYSA-N 4h-isochromene-1,3-dione Chemical compound C1=CC=C2C(=O)OC(=O)CC2=C1 AKHSBAVQPIRVAG-UHFFFAOYSA-N 0.000 abstract 1
- 238000005727 Friedel-Crafts reaction Methods 0.000 abstract 1
- 238000005642 Gabriel synthesis reaction Methods 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000001555 benzenes Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 abstract 1
- 229920000137 polyphosphoric acid Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
- C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
- C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE795722D BE795722A (fr) | 1972-02-24 | Nouveaux derives a activite anti-inflammatoire et antalgique | |
| FR7206402A FR2172868A1 (en) | 1972-02-24 | 1972-02-24 | Carboxy substd benzophenone derivs - as analgesics and antiinflammatory agents |
| DE19732308553 DE2308553A1 (de) | 1972-02-24 | 1973-02-21 | Aromatische ketonderivate |
| ES411993A ES411993A1 (es) | 1972-02-24 | 1973-02-23 | Un procedimiento de preparacion de derivados de ceto-acidosaromaticos. |
| CH268873A CH563954A5 (enExample) | 1972-02-24 | 1973-02-23 | |
| GB933773A GB1420355A (en) | 1972-02-24 | 1973-02-26 | Carboxy-containing diphenyl ketones and processes for preparing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7206402A FR2172868A1 (en) | 1972-02-24 | 1972-02-24 | Carboxy substd benzophenone derivs - as analgesics and antiinflammatory agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2172868A1 true FR2172868A1 (en) | 1973-10-05 |
| FR2172868B1 FR2172868B1 (enExample) | 1975-06-13 |
Family
ID=9094117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7206402A Granted FR2172868A1 (en) | 1972-02-24 | 1972-02-24 | Carboxy substd benzophenone derivs - as analgesics and antiinflammatory agents |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2172868A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0170105A3 (en) * | 1984-07-07 | 1986-03-26 | Koichi Prof. Dr. Shudo | Benzoic acid derivatives |
| DE3615339A1 (de) * | 1985-05-07 | 1986-11-13 | Oreal | Topische hautbehandlungsmittel auf basis von salicylsaeurederivaten |
| EP0514264A1 (fr) * | 1991-05-13 | 1992-11-19 | Centre International De Recherches Dermatologiques Galderma, ( Cird Galderma) | Composés bi-aromatiques dérivés d'un motif salicylique, leur procédé de préparation et leur utilisation en médecine humaine et vétérinaire ainsi qu'en cosmétique |
-
1972
- 1972-02-24 FR FR7206402A patent/FR2172868A1/fr active Granted
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0170105A3 (en) * | 1984-07-07 | 1986-03-26 | Koichi Prof. Dr. Shudo | Benzoic acid derivatives |
| DE3615339A1 (de) * | 1985-05-07 | 1986-11-13 | Oreal | Topische hautbehandlungsmittel auf basis von salicylsaeurederivaten |
| FR2581542A1 (fr) * | 1985-05-07 | 1986-11-14 | Oreal | Compositions topiques destinees au traitement de la peau a base de derives de l'acide salicylique |
| US4767750A (en) * | 1985-05-07 | 1988-08-30 | L'oreal | Topical compositions intended for skin treatment containing salicylic acid derivatives |
| EP0514264A1 (fr) * | 1991-05-13 | 1992-11-19 | Centre International De Recherches Dermatologiques Galderma, ( Cird Galderma) | Composés bi-aromatiques dérivés d'un motif salicylique, leur procédé de préparation et leur utilisation en médecine humaine et vétérinaire ainsi qu'en cosmétique |
| FR2676439A1 (fr) * | 1991-05-13 | 1992-11-20 | Cird Galderma | Nouveaux composes bi-aromatiques derives d'un motif salicylique, leur procede de preparation et leur utilisation en medecine humaine et veterinaire ainsi qu'en cosmetique. |
| WO1992020643A1 (fr) * | 1991-05-13 | 1992-11-26 | Centre International De Recherches Dermatologiques Galderma (Cird Galderma) | Nouveaux composes bi-aromatiques derives d'un motif salicylique, leur procede de preparation et leur utilisation en medecine humaine et veterinaire ainsi qu'en cosmetique |
| US5476860A (en) * | 1991-05-13 | 1995-12-19 | Centre International De Recherches Dermatologiques (Cird Galderma) | Diaromatic compounds derived from a salicylic unit and their use in human and veterinary medicine and in cosmetics |
| US5654331A (en) * | 1991-05-13 | 1997-08-05 | Centre International De Recherches Dermatologiques Galderma (Cird Galderma) | Diaromatic compounds derived from a salicylic unit and their use in human and veterinary medicine and in cosmetics |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2172868B1 (enExample) | 1975-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CA | Change of address | ||
| ST | Notification of lapse |