FR2147188A1 - N,N-bis (2-hydroxy-2-aryl-ethyl) diamines - bronchospasmolytics - Google Patents
N,N-bis (2-hydroxy-2-aryl-ethyl) diamines - bronchospasmolyticsInfo
- Publication number
- FR2147188A1 FR2147188A1 FR7226799A FR7226799A FR2147188A1 FR 2147188 A1 FR2147188 A1 FR 2147188A1 FR 7226799 A FR7226799 A FR 7226799A FR 7226799 A FR7226799 A FR 7226799A FR 2147188 A1 FR2147188 A1 FR 2147188A1
- Authority
- FR
- France
- Prior art keywords
- bronchospasmolytics
- hydroxy
- diamines
- aryl
- bis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000000572 bronchospasmolytic effect Effects 0.000 title abstract 2
- 150000004985 diamines Chemical class 0.000 title 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical group O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 2
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 230000002829 reductive effect Effects 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
- ASMAGUQIXDEQHT-UHFFFAOYSA-H trichloroalumane Chemical compound [Al+3].[Al+3].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-] ASMAGUQIXDEQHT-UHFFFAOYSA-H 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1104471 | 1971-07-27 | ||
| CH1124771 | 1971-07-30 | ||
| CH1124971A CH548976A (de) | 1971-07-30 | 1971-07-30 | Verfahren zur herstellung neuer bis ((4-hydroxy-3-hydroxymethylphenyl) aethanol)diamin-derivate. |
| CH1231971 | 1971-08-23 | ||
| CH160572A CH562194A5 (en) | 1972-02-03 | 1972-02-03 | N,N-bis (2-hydroxy-2-aryl-ethyl) diamines - bronchospasmolytics |
| CH160272A CH556814A (de) | 1971-07-28 | 1972-02-03 | Verfahren zur herstellung neuer bis ((4-hydroxy-3-hydroxymethylphenyl)aethanol)diamin-derivate. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2147188A1 true FR2147188A1 (en) | 1973-03-09 |
Family
ID=27543653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7226799A Withdrawn FR2147188A1 (en) | 1971-07-27 | 1972-07-26 | N,N-bis (2-hydroxy-2-aryl-ethyl) diamines - bronchospasmolytics |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE786713A (cg-RX-API-DMAC10.html) |
| DD (1) | DD99567A5 (cg-RX-API-DMAC10.html) |
| DE (1) | DE2236272A1 (cg-RX-API-DMAC10.html) |
| FR (1) | FR2147188A1 (cg-RX-API-DMAC10.html) |
| HU (1) | HU167045B (cg-RX-API-DMAC10.html) |
| IL (1) | IL39987A0 (cg-RX-API-DMAC10.html) |
| NL (1) | NL7210099A (cg-RX-API-DMAC10.html) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0196849A3 (en) * | 1985-03-27 | 1988-01-07 | Beecham Group Plc | Aminohydroxyalkylbenzene anti-obesity and/or anti-hyperglycaemic agents |
| WO2003099764A1 (en) * | 2002-05-28 | 2003-12-04 | Theravance, Inc. | ALKOXY ARYL β2 ADRENERGIC RECEPTOR AGONISTS |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6541669B1 (en) | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
| US6683115B2 (en) | 1999-06-02 | 2004-01-27 | Theravance, Inc. | β2-adrenergic receptor agonists |
| UA73965C2 (en) | 1999-12-08 | 2005-10-17 | Theravance Inc | b2 ADRENERGIC RECEPTOR ANTAGONISTS |
| US7268147B2 (en) * | 2003-05-15 | 2007-09-11 | Pfizer Inc | Compounds useful for the treatment of diseases |
| ES2265276B1 (es) | 2005-05-20 | 2008-02-01 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
| ES2306595B1 (es) | 2007-02-09 | 2009-09-11 | Laboratorios Almirall S.A. | Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2. |
| ES2320961B1 (es) | 2007-11-28 | 2010-03-17 | Laboratorios Almirall, S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor adrenergico beta2. |
| UY32297A (es) | 2008-12-22 | 2010-05-31 | Almirall Sa | Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico |
| EP2228368A1 (en) | 2009-03-12 | 2010-09-15 | Almirall, S.A. | Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one |
| EP2578570A1 (en) | 2011-10-07 | 2013-04-10 | Almirall, S.A. | Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis. |
| EP2641900A1 (en) | 2012-03-20 | 2013-09-25 | Almirall, S.A. | Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor. |
-
0
- BE BE786713D patent/BE786713A/xx unknown
-
1972
- 1972-07-21 NL NL7210099A patent/NL7210099A/xx unknown
- 1972-07-24 DE DE2236272A patent/DE2236272A1/de active Pending
- 1972-07-25 IL IL39987A patent/IL39987A0/xx unknown
- 1972-07-25 DD DD164661A patent/DD99567A5/xx unknown
- 1972-07-25 HU HUSA2378A patent/HU167045B/hu unknown
- 1972-07-26 FR FR7226799A patent/FR2147188A1/fr not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0196849A3 (en) * | 1985-03-27 | 1988-01-07 | Beecham Group Plc | Aminohydroxyalkylbenzene anti-obesity and/or anti-hyperglycaemic agents |
| WO2003099764A1 (en) * | 2002-05-28 | 2003-12-04 | Theravance, Inc. | ALKOXY ARYL β2 ADRENERGIC RECEPTOR AGONISTS |
| US6747043B2 (en) | 2002-05-28 | 2004-06-08 | Theravance, Inc. | Alkoxy aryl β2 adrenergic receptor agonists |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2236272A1 (de) | 1973-02-08 |
| IL39987A0 (en) | 1972-09-28 |
| DD99567A5 (cg-RX-API-DMAC10.html) | 1973-08-12 |
| BE786713A (fr) | 1973-01-25 |
| NL7210099A (cg-RX-API-DMAC10.html) | 1973-01-30 |
| HU167045B (cg-RX-API-DMAC10.html) | 1975-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |