FR2145430A1 - 3-chloro-4-cyclohexyl-alphamethyl benzylamines - - antiinflammatory and analgesic agents - Google Patents
3-chloro-4-cyclohexyl-alphamethyl benzylamines - - antiinflammatory and analgesic agentsInfo
- Publication number
- FR2145430A1 FR2145430A1 FR7125902A FR7125902A FR2145430A1 FR 2145430 A1 FR2145430 A1 FR 2145430A1 FR 7125902 A FR7125902 A FR 7125902A FR 7125902 A FR7125902 A FR 7125902A FR 2145430 A1 FR2145430 A1 FR 2145430A1
- Authority
- FR
- France
- Prior art keywords
- chloro
- alphamethyl
- benzylamines
- antiinflammatory
- cyclohexyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Cpds. (I) (where X is H, halogen esp. Cl, CN, or NR1R2; R1 and R2 are H, or alkyl or NR1R2 is a 5- or 6-membered heterocyclic ring, opt. unsatd. and opt. contg. a further heteroatom; and n is 1, 2 or 3 or is O when X is H) are prepd. either by reducing 3-chloro-4-cyclohexylacetophenone (II), halogenating the alcohol formed, and condensing the halo deriv. formed with NH2(CH2)nX, or by reductively aminating (II), or heating (II) with HCOONH4 and hydrolysing the product or heating (I, n = 0, X = H) with acrylonitrile. Prefd. cpds. are (I) where X = H, n = 0, 1 or 2 and X = Me2N or CN and n = 2.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7125902A FR2145430A1 (en) | 1971-07-15 | 1971-07-15 | 3-chloro-4-cyclohexyl-alphamethyl benzylamines - - antiinflammatory and analgesic agents |
BE774228A BE774228A (en) | 1970-10-28 | 1971-10-20 | NEW DERIVATIVES OF ALPHA-METHYLBENZYLAMINE |
GB4890371A GB1373544A (en) | 1970-10-28 | 1971-10-21 | Derivatives of alpha-methyl-benzyl-amine |
DE19712153535 DE2153535A1 (en) | 1970-10-28 | 1971-10-27 | New derivatives of alpha methylbenzyl amine |
US05/193,175 US4003931A (en) | 1970-10-28 | 1971-10-27 | Derivatives of alpha-methyl benzylamine |
CH1660871A CH545268A (en) | 1971-07-15 | 1971-11-16 | Process for the preparation of new derivatives of A-methylbenzylamine |
US469608A US3928603A (en) | 1970-10-28 | 1974-05-13 | New derivatives of alpha-methyl benzylamine in treating inflammation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7125902A FR2145430A1 (en) | 1971-07-15 | 1971-07-15 | 3-chloro-4-cyclohexyl-alphamethyl benzylamines - - antiinflammatory and analgesic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2145430A1 true FR2145430A1 (en) | 1973-02-23 |
FR2145430B1 FR2145430B1 (en) | 1974-09-06 |
Family
ID=9080398
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7125902A Granted FR2145430A1 (en) | 1970-10-28 | 1971-07-15 | 3-chloro-4-cyclohexyl-alphamethyl benzylamines - - antiinflammatory and analgesic agents |
Country Status (2)
Country | Link |
---|---|
CH (1) | CH545268A (en) |
FR (1) | FR2145430A1 (en) |
-
1971
- 1971-07-15 FR FR7125902A patent/FR2145430A1/en active Granted
- 1971-11-16 CH CH1660871A patent/CH545268A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CH545268A (en) | 1973-12-15 |
FR2145430B1 (en) | 1974-09-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |