FR2145430A1 - 3-chloro-4-cyclohexyl-alphamethyl benzylamines - - antiinflammatory and analgesic agents - Google Patents

3-chloro-4-cyclohexyl-alphamethyl benzylamines - - antiinflammatory and analgesic agents

Info

Publication number
FR2145430A1
FR2145430A1 FR7125902A FR7125902A FR2145430A1 FR 2145430 A1 FR2145430 A1 FR 2145430A1 FR 7125902 A FR7125902 A FR 7125902A FR 7125902 A FR7125902 A FR 7125902A FR 2145430 A1 FR2145430 A1 FR 2145430A1
Authority
FR
France
Prior art keywords
chloro
alphamethyl
benzylamines
antiinflammatory
cyclohexyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7125902A
Other languages
French (fr)
Other versions
FR2145430B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fuveau SA
Original Assignee
Fuveau SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuveau SA filed Critical Fuveau SA
Priority to FR7125902A priority Critical patent/FR2145430A1/en
Priority to BE774228A priority patent/BE774228A/en
Priority to GB4890371A priority patent/GB1373544A/en
Priority to DE19712153535 priority patent/DE2153535A1/en
Priority to US05/193,175 priority patent/US4003931A/en
Priority to CH1660871A priority patent/CH545268A/en
Publication of FR2145430A1 publication Critical patent/FR2145430A1/en
Priority to US469608A priority patent/US3928603A/en
Application granted granted Critical
Publication of FR2145430B1 publication Critical patent/FR2145430B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Cpds. (I) (where X is H, halogen esp. Cl, CN, or NR1R2; R1 and R2 are H, or alkyl or NR1R2 is a 5- or 6-membered heterocyclic ring, opt. unsatd. and opt. contg. a further heteroatom; and n is 1, 2 or 3 or is O when X is H) are prepd. either by reducing 3-chloro-4-cyclohexylacetophenone (II), halogenating the alcohol formed, and condensing the halo deriv. formed with NH2(CH2)nX, or by reductively aminating (II), or heating (II) with HCOONH4 and hydrolysing the product or heating (I, n = 0, X = H) with acrylonitrile. Prefd. cpds. are (I) where X = H, n = 0, 1 or 2 and X = Me2N or CN and n = 2.
FR7125902A 1970-10-28 1971-07-15 3-chloro-4-cyclohexyl-alphamethyl benzylamines - - antiinflammatory and analgesic agents Granted FR2145430A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR7125902A FR2145430A1 (en) 1971-07-15 1971-07-15 3-chloro-4-cyclohexyl-alphamethyl benzylamines - - antiinflammatory and analgesic agents
BE774228A BE774228A (en) 1970-10-28 1971-10-20 NEW DERIVATIVES OF ALPHA-METHYLBENZYLAMINE
GB4890371A GB1373544A (en) 1970-10-28 1971-10-21 Derivatives of alpha-methyl-benzyl-amine
DE19712153535 DE2153535A1 (en) 1970-10-28 1971-10-27 New derivatives of alpha methylbenzyl amine
US05/193,175 US4003931A (en) 1970-10-28 1971-10-27 Derivatives of alpha-methyl benzylamine
CH1660871A CH545268A (en) 1971-07-15 1971-11-16 Process for the preparation of new derivatives of A-methylbenzylamine
US469608A US3928603A (en) 1970-10-28 1974-05-13 New derivatives of alpha-methyl benzylamine in treating inflammation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7125902A FR2145430A1 (en) 1971-07-15 1971-07-15 3-chloro-4-cyclohexyl-alphamethyl benzylamines - - antiinflammatory and analgesic agents

Publications (2)

Publication Number Publication Date
FR2145430A1 true FR2145430A1 (en) 1973-02-23
FR2145430B1 FR2145430B1 (en) 1974-09-06

Family

ID=9080398

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7125902A Granted FR2145430A1 (en) 1970-10-28 1971-07-15 3-chloro-4-cyclohexyl-alphamethyl benzylamines - - antiinflammatory and analgesic agents

Country Status (2)

Country Link
CH (1) CH545268A (en)
FR (1) FR2145430A1 (en)

Also Published As

Publication number Publication date
CH545268A (en) 1973-12-15
FR2145430B1 (en) 1974-09-06

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Legal Events

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