FR2139269A5 - Antiarrhythmic piperazine derivs prepn - from benzhydrylpiperazine cinnamaldehyde by leuckart reactn - Google Patents

Antiarrhythmic piperazine derivs prepn - from benzhydrylpiperazine cinnamaldehyde by leuckart reactn

Info

Publication number
FR2139269A5
FR2139269A5 FR7215259A FR7215259A FR2139269A5 FR 2139269 A5 FR2139269 A5 FR 2139269A5 FR 7215259 A FR7215259 A FR 7215259A FR 7215259 A FR7215259 A FR 7215259A FR 2139269 A5 FR2139269 A5 FR 2139269A5
Authority
FR
France
Prior art keywords
benzhydrylpiperazine
cinnamaldehyde
reactn
leuckart
antiarrhythmic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7215259A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Japan Co Ltd
Original Assignee
Hokuriku Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP46070338A external-priority patent/JPS4834889A/ja
Application filed by Hokuriku Pharmaceutical Co Ltd filed Critical Hokuriku Pharmaceutical Co Ltd
Application granted granted Critical
Publication of FR2139269A5 publication Critical patent/FR2139269A5/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Abstract

Cpds. of formula: (where R1 and R2 are H or halogen; R3 is H or Ph) are prepd. by reacting a benzhydrylpiperazine with a beta-R3-cinnamaldehyde in the presence of formic acid. The cpds. also show neuroleptic and analgesic activity.
FR7215259A 1971-05-12 1972-04-28 Antiarrhythmic piperazine derivs prepn - from benzhydrylpiperazine cinnamaldehyde by leuckart reactn Expired FR2139269A5 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3119571 1971-05-12
JP46070338A JPS4834889A (en) 1971-09-13 1971-09-13

Publications (1)

Publication Number Publication Date
FR2139269A5 true FR2139269A5 (en) 1973-01-05

Family

ID=26369645

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7215259A Expired FR2139269A5 (en) 1971-05-12 1972-04-28 Antiarrhythmic piperazine derivs prepn - from benzhydrylpiperazine cinnamaldehyde by leuckart reactn

Country Status (3)

Country Link
DE (1) DE2220242A1 (en)
ES (1) ES402551A1 (en)
FR (1) FR2139269A5 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5427587A (en) * 1977-08-02 1979-03-01 Takeda Chem Ind Ltd 1,2-dihydronaphthalene compound and its preparation

Also Published As

Publication number Publication date
DE2220242A1 (en) 1972-11-16
ES402551A1 (en) 1975-04-01

Similar Documents

Publication Publication Date Title
GB1383083A (en) Thiazolidine derivatives
FR2154082A5 (en) Antiarrhythmic piperazine derivs prepn - from benzhydrylpiperazine cinnamaldehyde by leuckart reactn
FR2139269A5 (en) Antiarrhythmic piperazine derivs prepn - from benzhydrylpiperazine cinnamaldehyde by leuckart reactn
BE782977A (en) Antiarrhythmic piperazine derivs prepn - from benzhydrylpiperazine cinnamaldehyde by leuckart reactn
GB1271449A (en) Production of iron oxide pigments
GB1370960A (en)
ES427511A1 (en) Process for preparing triacetonamine
IT1057859B (en) Triamcinolone derivs - as antiinflammatory agents
GB1409993A (en) Antitussive
FR2150594A1 (en) Omega-amino-1,2-diphenyl-1-alkanones - with analgesic antiinflammatory anti-ulcer,bronchodilator,spasmolytic and hypotensive
FR2173172A1 (en) 5-carbamoyl-iminodibenzyls and iminostilbenes prepn - with anticonvulsant, muscle relaxant and sedative-tranquillizing props
FR2128179A1 (en) 1-benzoylvinyl-4-subst piperazines - analgesics and antiinflammatories
FR2142809A1 (en) 3-hydroxy-3-methyl-2-methylene pyrrolidinium iodides - with vasodilator, hypotensive and analgesic activity
FR2121443A1 (en) Indolecarboxylic acid hydrazide derivs - hypotensives analgesics and antiinflammatories
ES396302A1 (en) Procedure for the manufacture of 1-aril 2,3,4,5-tetrahydro-1H-1,5 benzodiacepin - 2 -ones. (Machine-translation by Google Translate, not legally binding)
FR2175040A1 (en) Vincaminic acid amines - cerebral microcirculatory active
FR2143526A1 (en) 3-carboxy-4-salicyloxy-6-sulphamoylquinolines - with analgesic,antiinflammatory, antipyretic, antirheumatic activity
ES430021A1 (en) Preparation of a benzamide
FR2210388A1 (en) 4-Phenoxy-3-hydroxy-butyramidines - as agents for treating cardiac rhythm disorders
FR2059507A1 (en) Ampicillin from a new intermediate
FR2116244A1 (en) Alkylene diamines - and phosphoramides - from bromoalkylamines and diesterified orthophosphoric acid halides
ES409555A1 (en) A procedure for the obtaining of new derivatives of cefalosporine. (Machine-translation by Google Translate, not legally binding)
FR2146137A1 (en) 1,10-diaminoethylthio decanes - hypotensives
ES242315A1 (en) A procedure for the production of a piperazine salt (Machine-translation by Google Translate, not legally binding)
FR2245347A1 (en) Aminoalkyl thionicotinates - with hypocholesterolaemic, hypolipaemic, antiinflammatory and antibradykinin activity

Legal Events

Date Code Title Description
ST Notification of lapse