FR2059507A1 - Ampicillin from a new intermediate - Google Patents

Ampicillin from a new intermediate

Info

Publication number
FR2059507A1
FR2059507A1 FR7025823A FR7025823A FR2059507A1 FR 2059507 A1 FR2059507 A1 FR 2059507A1 FR 7025823 A FR7025823 A FR 7025823A FR 7025823 A FR7025823 A FR 7025823A FR 2059507 A1 FR2059507 A1 FR 2059507A1
Authority
FR
France
Prior art keywords
ampicillin
reaction
new intermediate
acid
hydroxybenzylester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7025823A
Other languages
French (fr)
Other versions
FR2059507B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of FR2059507A1 publication Critical patent/FR2059507A1/en
Application granted granted Critical
Publication of FR2059507B1 publication Critical patent/FR2059507B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The 6-]D(-)-alpha-aminophenylacetamido penicillic acid 3',5'-di-t-butyl-4'-hydroxybenzylester is used to prepare ampicillin by reacting with a weak basic material. Pref. a primary or secondary amine or an alkylithiophenolate is used as the base. Preferably, the reaction is carried out in anhydrous condns. Used as an antibiotic. Advantages are that difficulties connected with the use of 6-aminopenicillin acid as intermediate are avoided and the reaction is economical and clean.
FR7025823A 1969-07-12 1970-07-10 Ampicillin from a new intermediate Granted FR2059507A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP5561869 1969-07-12
JP6386869 1969-08-14
JP9495569 1969-11-27
JP1065770 1970-02-09
JP1815870 1970-03-03
JP2215370 1970-03-16

Publications (2)

Publication Number Publication Date
FR2059507A1 true FR2059507A1 (en) 1971-06-04
FR2059507B1 FR2059507B1 (en) 1974-08-09

Family

ID=27548282

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7025823A Granted FR2059507A1 (en) 1969-07-12 1970-07-10 Ampicillin from a new intermediate

Country Status (6)

Country Link
CH (1) CH539074A (en)
DE (1) DE2033493A1 (en)
DK (1) DK133987B (en)
FI (1) FI52983C (en)
FR (1) FR2059507A1 (en)
SE (1) SE379201B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS538717B1 (en) * 1971-06-15 1978-03-31

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Also Published As

Publication number Publication date
DK133987C (en) 1977-01-31
DE2033493A1 (en) 1971-01-28
DK133987B (en) 1976-08-23
SE379201B (en) 1975-09-29
FI52983B (en) 1977-09-30
FI52983C (en) 1978-01-10
FR2059507B1 (en) 1974-08-09
CH539074A (en) 1973-07-15

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Legal Events

Date Code Title Description
ST Notification of lapse