FR2108986A1 - 3-chloro-4-cyclohexyl-alphamethyl benzylamines - - antiinflammatory and analgesic agents - Google Patents
3-chloro-4-cyclohexyl-alphamethyl benzylamines - - antiinflammatory and analgesic agentsInfo
- Publication number
- FR2108986A1 FR2108986A1 FR7038818A FR7038818A FR2108986A1 FR 2108986 A1 FR2108986 A1 FR 2108986A1 FR 7038818 A FR7038818 A FR 7038818A FR 7038818 A FR7038818 A FR 7038818A FR 2108986 A1 FR2108986 A1 FR 2108986A1
- Authority
- FR
- France
- Prior art keywords
- chloro
- alphamethyl
- benzylamines
- antiinflammatory
- cyclohexyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Cpds. (I) (where X is H, halogen esp. Cl, CN, or NR1R2; R1 and R2 are H, or alkyl or NR1R2 is a 5- or 6-membered heterocyclic ring, opt. unsatd. and opt. contg. a further heteroatom; and n is 1, 2 or 3 or is O when X is H) are prepd. either by reducing 3-chloro-4-cyclohexylacetophenone (II), halogenating the alcohol formed, and condensing the halo deriv. formed with NH2(CH2)nX, or by reductively aminating (II), or heating (II) with HCOONH4 and hydrolysing the product or heating (I, n = 0, X = H) with acrylonitrile. Prefd. cpds. are (I) where X = H, n = 0, 1 or 2 and X = Me2N or CN and n = 2.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7038818A FR2108986A1 (en) | 1970-10-28 | 1970-10-28 | 3-chloro-4-cyclohexyl-alphamethyl benzylamines - - antiinflammatory and analgesic agents |
BE774228A BE774228A (en) | 1970-10-28 | 1971-10-20 | NEW DERIVATIVES OF ALPHA-METHYLBENZYLAMINE |
CH1529571A CH544061A (en) | 1970-10-28 | 1971-10-20 | Process for preparing 3-chloro-4-cyclohexyl alpha-methylbenzylamine |
GB4890371A GB1373544A (en) | 1970-10-28 | 1971-10-21 | Derivatives of alpha-methyl-benzyl-amine |
US05/193,175 US4003931A (en) | 1970-10-28 | 1971-10-27 | Derivatives of alpha-methyl benzylamine |
DE19712153535 DE2153535A1 (en) | 1970-10-28 | 1971-10-27 | New derivatives of alpha methylbenzyl amine |
US469608A US3928603A (en) | 1970-10-28 | 1974-05-13 | New derivatives of alpha-methyl benzylamine in treating inflammation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7038818A FR2108986A1 (en) | 1970-10-28 | 1970-10-28 | 3-chloro-4-cyclohexyl-alphamethyl benzylamines - - antiinflammatory and analgesic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2108986A1 true FR2108986A1 (en) | 1972-05-26 |
FR2108986B1 FR2108986B1 (en) | 1974-02-01 |
Family
ID=9063380
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7038818A Granted FR2108986A1 (en) | 1970-10-28 | 1970-10-28 | 3-chloro-4-cyclohexyl-alphamethyl benzylamines - - antiinflammatory and analgesic agents |
Country Status (2)
Country | Link |
---|---|
CH (1) | CH544061A (en) |
FR (1) | FR2108986A1 (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE601925A (en) * | 1961-03-28 | 1961-07-17 | Labofina Sa | New arylalkylamine and manufacturing process. |
-
1970
- 1970-10-28 FR FR7038818A patent/FR2108986A1/en active Granted
-
1971
- 1971-10-20 CH CH1529571A patent/CH544061A/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE601925A (en) * | 1961-03-28 | 1961-07-17 | Labofina Sa | New arylalkylamine and manufacturing process. |
Also Published As
Publication number | Publication date |
---|---|
CH544061A (en) | 1973-11-15 |
FR2108986B1 (en) | 1974-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |