FR2132838A1 - Pyrido(3,2-d)pyrimidines - anticoagulants - Google Patents

Pyrido(3,2-d)pyrimidines - anticoagulants

Info

Publication number
FR2132838A1
FR2132838A1 FR7212538A FR7212538A FR2132838A1 FR 2132838 A1 FR2132838 A1 FR 2132838A1 FR 7212538 A FR7212538 A FR 7212538A FR 7212538 A FR7212538 A FR 7212538A FR 2132838 A1 FR2132838 A1 FR 2132838A1
Authority
FR
France
Prior art keywords
anticoagulants
thiomorpholino
analogues
pyrido
pyrimidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7212538A
Other languages
French (fr)
Other versions
FR2132838B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19712117657 external-priority patent/DE2117657B2/en
Priority claimed from DE19722202367 external-priority patent/DE2202367A1/en
Priority claimed from DE19722206535 external-priority patent/DE2206535B1/en
Priority claimed from DE19722208534 external-priority patent/DE2208534A1/en
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of FR2132838A1 publication Critical patent/FR2132838A1/en
Application granted granted Critical
Publication of FR2132838B1 publication Critical patent/FR2132838B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Title cmpds. are of formula I, where R1 and R2 = morpholino, thiomorpholino, 1-oxidothiomorpholino, 1,1-dioxidothiomorpholino or piperidino all opt. substd. by N-acyl, N-carbamoyl or lower alkyl, dialkamolamino, or alkylenediamino; and R3 = H or Me; and salts of I, and are of use as anticoagulants. I are prepd. (a) by reacting analogues where R, and/or R2 is a labile residue, with an amine HR1 and/or HR2 (b) by deacylating analogues where R1 and/or R2 are 4-acylpiperazine, (c) by oxidising I (R1 = thiomorpholino), (d) by condensing a 2-R1 4-R2 5-aminopyrimidine with acrolein, crotonaldehyde or glycerol in the presence of an acid and an oxidising agent.
FR7212538A 1971-04-10 1972-04-10 Pyrido(3,2-d)pyrimidines - anticoagulants Granted FR2132838A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19712117657 DE2117657B2 (en) 1971-04-10 1971-04-10 PYRIDO SQUARE BRACKET ON 3.2-ANGLE BRACKET FOR PYRIMIDINE
DE19722202367 DE2202367A1 (en) 1972-01-19 1972-01-19 Pyrido(3,2-d)pyrimidines - anticoagulants
DE19722206535 DE2206535B1 (en) 1972-02-11 1972-02-11 Tunnel kiln roof - using mating refractory bricks to produce flat surface free from distortion
DE19722208534 DE2208534A1 (en) 1972-02-23 1972-02-23 Pyrido(3,2-d)pyrimidines - anticoagulants

Publications (2)

Publication Number Publication Date
FR2132838A1 true FR2132838A1 (en) 1972-11-24
FR2132838B1 FR2132838B1 (en) 1975-10-10

Family

ID=27431238

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7212538A Granted FR2132838A1 (en) 1971-04-10 1972-04-10 Pyrido(3,2-d)pyrimidines - anticoagulants

Country Status (1)

Country Link
FR (1) FR2132838A1 (en)

Also Published As

Publication number Publication date
FR2132838B1 (en) 1975-10-10

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Legal Events

Date Code Title Description
ST Notification of lapse