FR2123524A1 - N-blocked insulin derivs - with high water solubility, and the corresp o-blocked cpds - Google Patents
N-blocked insulin derivs - with high water solubility, and the corresp o-blocked cpdsInfo
- Publication number
- FR2123524A1 FR2123524A1 FR7202946A FR7202946A FR2123524A1 FR 2123524 A1 FR2123524 A1 FR 2123524A1 FR 7202946 A FR7202946 A FR 7202946A FR 7202946 A FR7202946 A FR 7202946A FR 2123524 A1 FR2123524 A1 FR 2123524A1
- Authority
- FR
- France
- Prior art keywords
- blocked
- derivs
- insulin
- cpds
- corresp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
- 102000004877 Insulin Human genes 0.000 title abstract 3
- 108090001061 Insulin Proteins 0.000 title abstract 3
- 229940125396 insulin Drugs 0.000 title abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 2
- 125000004080 3-carboxypropanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C(O[H])=O 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- -1 glutaryl Chemical group 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB338771A GB1381273A (en) | 1971-01-28 | 1971-01-28 | Insulin derivatives |
| GB338871A GB1381274A (en) | 1971-01-28 | 1971-01-28 | Insulin derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2123524A1 true FR2123524A1 (en) | 1972-09-08 |
| FR2123524B1 FR2123524B1 (enrdf_load_stackoverflow) | 1975-12-26 |
Family
ID=26238276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7202946A Granted FR2123524A1 (en) | 1971-01-28 | 1972-01-28 | N-blocked insulin derivs - with high water solubility, and the corresp o-blocked cpds |
Country Status (8)
| Country | Link |
|---|---|
| AU (1) | AU472582B2 (enrdf_load_stackoverflow) |
| BE (1) | BE778538A (enrdf_load_stackoverflow) |
| CH (1) | CH547777A (enrdf_load_stackoverflow) |
| DE (1) | DE2204053A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2123524A1 (enrdf_load_stackoverflow) |
| IE (1) | IE36225B1 (enrdf_load_stackoverflow) |
| NL (1) | NL7201179A (enrdf_load_stackoverflow) |
| SE (1) | SE382452B (enrdf_load_stackoverflow) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2160619A1 (enrdf_load_stackoverflow) * | 1971-11-18 | 1973-06-29 | Nat Res Dev | |
| FR2161063A1 (enrdf_load_stackoverflow) * | 1971-11-27 | 1973-07-06 | Schering Ag | |
| FR2181779A1 (enrdf_load_stackoverflow) * | 1972-03-01 | 1973-12-07 | Bayer Ag | |
| FR2181778A1 (enrdf_load_stackoverflow) * | 1972-03-01 | 1973-12-07 | Bayer Ag | |
| FR2204616A1 (enrdf_load_stackoverflow) * | 1972-10-25 | 1974-05-24 | Hoechst Ag | |
| FR2204617A2 (enrdf_load_stackoverflow) * | 1972-10-31 | 1974-05-24 | Hoechst Ag | |
| FR2204618A1 (enrdf_load_stackoverflow) * | 1972-10-31 | 1974-05-24 | Hoechst Ag | |
| FR2307541A1 (fr) * | 1975-04-15 | 1976-11-12 | Wellcome Found | Medicament a base d'un polypeptide |
| US4175122A (en) * | 1975-04-15 | 1979-11-20 | Burroughs Wellcome Co. | Biologically active amides |
| US4223017A (en) * | 1975-04-15 | 1980-09-16 | Burroughs Wellcome Co. | Biologically active amides |
| FR2925333A1 (fr) * | 2007-12-19 | 2009-06-26 | Farid Bennis | Compositions pharmaceutiques renfermant au moins un principe actif proteinique protege des enzymes digestives |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK179286D0 (da) * | 1986-04-18 | 1986-04-18 | Nordisk Gentofte | Insulinpraeparat |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3528960A (en) * | 1968-10-07 | 1970-09-15 | Lilly Co Eli | N-carboxyaroyl insulins |
-
1972
- 1972-01-12 IE IE4672A patent/IE36225B1/xx unknown
- 1972-01-24 AU AU38213/72A patent/AU472582B2/en not_active Expired
- 1972-01-26 BE BE778538A patent/BE778538A/xx unknown
- 1972-01-27 SE SE94972A patent/SE382452B/xx unknown
- 1972-01-28 FR FR7202946A patent/FR2123524A1/fr active Granted
- 1972-01-28 DE DE19722204053 patent/DE2204053A1/de active Pending
- 1972-01-28 NL NL7201179A patent/NL7201179A/xx unknown
- 1972-01-28 CH CH125672A patent/CH547777A/fr not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3528960A (en) * | 1968-10-07 | 1970-09-15 | Lilly Co Eli | N-carboxyaroyl insulins |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2160619A1 (enrdf_load_stackoverflow) * | 1971-11-18 | 1973-06-29 | Nat Res Dev | |
| FR2161063A1 (enrdf_load_stackoverflow) * | 1971-11-27 | 1973-07-06 | Schering Ag | |
| FR2181779A1 (enrdf_load_stackoverflow) * | 1972-03-01 | 1973-12-07 | Bayer Ag | |
| FR2181778A1 (enrdf_load_stackoverflow) * | 1972-03-01 | 1973-12-07 | Bayer Ag | |
| FR2204616A1 (enrdf_load_stackoverflow) * | 1972-10-25 | 1974-05-24 | Hoechst Ag | |
| FR2204617A2 (enrdf_load_stackoverflow) * | 1972-10-31 | 1974-05-24 | Hoechst Ag | |
| FR2204618A1 (enrdf_load_stackoverflow) * | 1972-10-31 | 1974-05-24 | Hoechst Ag | |
| FR2307541A1 (fr) * | 1975-04-15 | 1976-11-12 | Wellcome Found | Medicament a base d'un polypeptide |
| US4175122A (en) * | 1975-04-15 | 1979-11-20 | Burroughs Wellcome Co. | Biologically active amides |
| US4223017A (en) * | 1975-04-15 | 1980-09-16 | Burroughs Wellcome Co. | Biologically active amides |
| US4355025A (en) * | 1975-04-15 | 1982-10-19 | Burroughs Wellcome Co. | Biologically active amides |
| FR2925333A1 (fr) * | 2007-12-19 | 2009-06-26 | Farid Bennis | Compositions pharmaceutiques renfermant au moins un principe actif proteinique protege des enzymes digestives |
| WO2009083686A1 (fr) * | 2007-12-19 | 2009-07-09 | Farid Bennis | Compositions pharmaceutiques renfermant au moins un principe actif proteinique protege des enzymes digestives |
| AP3573A (en) * | 2007-12-19 | 2016-02-08 | Farid Bennis | Pharmaceutical compositions containing at least one proteinaceous active ingredient protected against digestive enzymes |
| EA023107B1 (ru) * | 2007-12-19 | 2016-04-29 | Фарид Беннис | Фармацевтическая композиция, содержащая по меньшей мере один белковый активный ингредиент, защищенный от расщепления ферментами |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2123524B1 (enrdf_load_stackoverflow) | 1975-12-26 |
| SE382452B (sv) | 1976-02-02 |
| IE36225B1 (en) | 1976-09-15 |
| CH547777A (fr) | 1974-04-11 |
| DE2204053A1 (de) | 1972-08-17 |
| AU3821372A (en) | 1973-07-26 |
| NL7201179A (enrdf_load_stackoverflow) | 1972-08-01 |
| IE36225L (en) | 1972-07-28 |
| AU472582B2 (en) | 1976-05-27 |
| BE778538A (fr) | 1972-07-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |