FR2070103A1 - Antiphlogistic 1- (hydroxy amido or amino) - acenaphthenes - Google Patents

Antiphlogistic 1- (hydroxy amido or amino) - acenaphthenes

Info

Publication number
FR2070103A1
FR2070103A1 FR7035553A FR7035553A FR2070103A1 FR 2070103 A1 FR2070103 A1 FR 2070103A1 FR 7035553 A FR7035553 A FR 7035553A FR 7035553 A FR7035553 A FR 7035553A FR 2070103 A1 FR2070103 A1 FR 2070103A1
Authority
FR
France
Prior art keywords
acenaphthenes
antiphlogistic
amino
alkyl
hydroxy amido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7035553A
Other languages
French (fr)
Other versions
FR2070103B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2070103A1 publication Critical patent/FR2070103A1/en
Application granted granted Critical
Publication of FR2070103B1 publication Critical patent/FR2070103B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Antiphlogistic 1-(hydroxy, amido or amino)-acenaphthenes. Title cpds. are those of formula:- (where R1 is 1-6C alkyl; R2 is H or 1-6C alkyl; Y is OH or -NH-Z-R3 in which Z is CO or CH2 and R3 is H, alkyl, aryl, alkylaryl or arylalkyl; and X is H, halogen, or 1-6C alkyl, alkoxy, haloalkyl or haloalkoxy) and their salts with acids. (I; Y=OH) may be prepd. by reduction of corr. 1-acenaphthones. Reaction of (I; Y = OH) with R3-CN in the presence of acid yields (I; Y = -NH-CO-R3), and reduction of the latter yields (I; Y = -NH-CH2-R3).
FR7035553A 1969-10-01 1970-10-01 Antiphlogistic 1- (hydroxy amido or amino) - acenaphthenes Granted FR2070103A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86295169A 1969-10-01 1969-10-01

Publications (2)

Publication Number Publication Date
FR2070103A1 true FR2070103A1 (en) 1971-09-10
FR2070103B1 FR2070103B1 (en) 1974-03-22

Family

ID=25339827

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7035553A Granted FR2070103A1 (en) 1969-10-01 1970-10-01 Antiphlogistic 1- (hydroxy amido or amino) - acenaphthenes

Country Status (4)

Country Link
CH (1) CH529726A (en)
DE (1) DE2048147A1 (en)
FR (1) FR2070103A1 (en)
HU (1) HU162666B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8700083A (en) * 1986-01-29 1987-08-17 Sandoz Ag AMINES ACTING AGAINST FUNGI, METHODS FOR THE PREPARATION THEREOF AND THEIR USE

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2569814A (en) * 1948-12-15 1951-10-02 Smith Kline French Lab beta-haloethylamines
FR1458078A (en) * 1963-10-18 1966-03-04 Ciba Geigy Process for preparing new acenaphthenes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2569814A (en) * 1948-12-15 1951-10-02 Smith Kline French Lab beta-haloethylamines
FR1458078A (en) * 1963-10-18 1966-03-04 Ciba Geigy Process for preparing new acenaphthenes

Also Published As

Publication number Publication date
HU162666B (en) 1973-03-28
CH529726A (en) 1972-10-31
DE2048147A1 (en) 1971-04-08
FR2070103B1 (en) 1974-03-22

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Legal Events

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