FR2070103A1 - Antiphlogistic 1- (hydroxy amido or amino) - acenaphthenes - Google Patents
Antiphlogistic 1- (hydroxy amido or amino) - acenaphthenesInfo
- Publication number
- FR2070103A1 FR2070103A1 FR7035553A FR7035553A FR2070103A1 FR 2070103 A1 FR2070103 A1 FR 2070103A1 FR 7035553 A FR7035553 A FR 7035553A FR 7035553 A FR7035553 A FR 7035553A FR 2070103 A1 FR2070103 A1 FR 2070103A1
- Authority
- FR
- France
- Prior art keywords
- acenaphthenes
- antiphlogistic
- amino
- alkyl
- hydroxy amido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002260 anti-inflammatory agent Substances 0.000 title abstract 2
- 230000001741 anti-phlogistic effect Effects 0.000 title abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- JBXIOAKUBCTDES-UHFFFAOYSA-N 2h-acenaphthylen-1-one Chemical class C1=CC(C(=O)C2)=C3C2=CC=CC3=C1 JBXIOAKUBCTDES-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Antiphlogistic 1-(hydroxy, amido or amino)-acenaphthenes. Title cpds. are those of formula:- (where R1 is 1-6C alkyl; R2 is H or 1-6C alkyl; Y is OH or -NH-Z-R3 in which Z is CO or CH2 and R3 is H, alkyl, aryl, alkylaryl or arylalkyl; and X is H, halogen, or 1-6C alkyl, alkoxy, haloalkyl or haloalkoxy) and their salts with acids. (I; Y=OH) may be prepd. by reduction of corr. 1-acenaphthones. Reaction of (I; Y = OH) with R3-CN in the presence of acid yields (I; Y = -NH-CO-R3), and reduction of the latter yields (I; Y = -NH-CH2-R3).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86295169A | 1969-10-01 | 1969-10-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2070103A1 true FR2070103A1 (en) | 1971-09-10 |
| FR2070103B1 FR2070103B1 (en) | 1974-03-22 |
Family
ID=25339827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7035553A Granted FR2070103A1 (en) | 1969-10-01 | 1970-10-01 | Antiphlogistic 1- (hydroxy amido or amino) - acenaphthenes |
Country Status (4)
| Country | Link |
|---|---|
| CH (1) | CH529726A (en) |
| DE (1) | DE2048147A1 (en) |
| FR (1) | FR2070103A1 (en) |
| HU (1) | HU162666B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8700083A (en) * | 1986-01-29 | 1987-08-17 | Sandoz Ag | AMINES ACTING AGAINST FUNGI, METHODS FOR THE PREPARATION THEREOF AND THEIR USE |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2569814A (en) * | 1948-12-15 | 1951-10-02 | Smith Kline French Lab | beta-haloethylamines |
| FR1458078A (en) * | 1963-10-18 | 1966-03-04 | Ciba Geigy | Process for preparing new acenaphthenes |
-
1970
- 1970-09-30 DE DE19702048147 patent/DE2048147A1/en active Pending
- 1970-10-01 CH CH1453570A patent/CH529726A/en not_active IP Right Cessation
- 1970-10-01 HU HUSU000566 patent/HU162666B/hu unknown
- 1970-10-01 FR FR7035553A patent/FR2070103A1/en active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2569814A (en) * | 1948-12-15 | 1951-10-02 | Smith Kline French Lab | beta-haloethylamines |
| FR1458078A (en) * | 1963-10-18 | 1966-03-04 | Ciba Geigy | Process for preparing new acenaphthenes |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2048147A1 (en) | 1971-04-08 |
| FR2070103B1 (en) | 1974-03-22 |
| HU162666B (en) | 1973-03-28 |
| CH529726A (en) | 1972-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |