FR2068429A1 - 2-phenylthio-and 2-phenoxypyridines antiinflammatory - Google Patents

2-phenylthio-and 2-phenoxypyridines antiinflammatory

Info

Publication number
FR2068429A1
FR2068429A1 FR6939113A FR6939113A FR2068429A1 FR 2068429 A1 FR2068429 A1 FR 2068429A1 FR 6939113 A FR6939113 A FR 6939113A FR 6939113 A FR6939113 A FR 6939113A FR 2068429 A1 FR2068429 A1 FR 2068429A1
Authority
FR
France
Prior art keywords
phenylthio
antiinflammatory
tetrazolyl
cooh
phenoxypyridines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR6939113A
Other languages
French (fr)
Other versions
FR2068429B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to FR6939113A priority Critical patent/FR2068429A1/en
Publication of FR2068429A1 publication Critical patent/FR2068429A1/en
Application granted granted Critical
Publication of FR2068429B1 publication Critical patent/FR2068429B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3

Abstract

2-Phenylthio- and 2-phenoxy pyridines antiinflammatory. Antiinflammatory agents for human and veterinary use are of formula (I): and their salts with acids and bases; (X=O,S; R=CN, COOH, 5-tetrazolyl; R1, R2, R3, R4, R5= H, alkyl, perfluoroalky, alkoxy, alkylthio, halogen (esp. F, Cl) (I) are prepd. by reaction of 3-cyano-2-hydroxy pyridine with POCl3, treating the resultant 2-chloro-3-cyanopyridine with the appropriate phenol or thio-phenol, finally converting the CN gp. if desired to COOH or Carageenan- induced oedema of the rat foot is inhibited by 2-phenylthio-3-(5-tetrazolyl) pyridine by 54, 64, 66 and 71% after 1,2,3 or 4 hr. respectively.
FR6939113A 1969-11-14 1969-11-14 2-phenylthio-and 2-phenoxypyridines antiinflammatory Granted FR2068429A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR6939113A FR2068429A1 (en) 1969-11-14 1969-11-14 2-phenylthio-and 2-phenoxypyridines antiinflammatory

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6939113A FR2068429A1 (en) 1969-11-14 1969-11-14 2-phenylthio-and 2-phenoxypyridines antiinflammatory

Publications (2)

Publication Number Publication Date
FR2068429A1 true FR2068429A1 (en) 1971-08-27
FR2068429B1 FR2068429B1 (en) 1973-01-12

Family

ID=9043025

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6939113A Granted FR2068429A1 (en) 1969-11-14 1969-11-14 2-phenylthio-and 2-phenoxypyridines antiinflammatory

Country Status (1)

Country Link
FR (1) FR2068429A1 (en)

Also Published As

Publication number Publication date
FR2068429B1 (en) 1973-01-12

Similar Documents

Publication Publication Date Title
ES416597A1 (en) Process for the preparation of purified albumin by thermocoagulation and albumin obtained by said process
AT324341B (en) PROCESS FOR THE PRODUCTION OF NEW PYRIDINE DERIVATIVES AND THEIR ACID ADDITIONAL SALTS
SE7608981L (en) PROCEDURE FOR REGULATING THE ACID SUPPLY IN TREATMENT OF WASTEWATER
FR2205333A1 (en) 6-Phenanthridone-3-carboxylic or-acetic acids - useful as gastric sec-retion inhibitors and anti-ulcer agents
GB1100825A (en) Polyfluoropyridine compounds
FR2068429A1 (en) 2-phenylthio-and 2-phenoxypyridines antiinflammatory
FR2275209A1 (en) Oxoalkyl esters of vincamine acids - and their pharm. acceptable salts for use in medicine
SE7613090L (en) PICOLIC ACID DERIVATIVE AND PROCEDURES FOR THE PREPARATION THEREOF
ES416217A1 (en) Chromanol nicotinate derivatives
FR2549834B1 (en) TRIAZOLO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION AS TONICARDIANS
ES406004A1 (en) 3-(5-oxyphenethyl)-glutarimides
ES471336A1 (en) Highly selective oxidizing process for preparing pyridin-carboxylic acids
ATE84024T1 (en) PROCESS FOR THE PREPARATION OF 2,2DIBROMONITRILOPROPIONS|UREAMID.
DE3870943D1 (en) METHOD FOR PRODUCING 7-CHLORINE-CHINOLIN-8-CARBONIC ACIDS.
GB1296655A (en)
EP0204975A3 (en) Process for preparing substituted tetralones
FR2154326A1 (en) (7' or 8' chloro-4-quinolinyl)-2-amino-nicotinic acid derivs - - analgesic,antiinflammatory
GB1167274A (en) Process for the Production of Cyclic Carboxylic Acids
ATE5048T1 (en) PROCESS FOR PREPARING CONCENTRATED SOLUTIONS OF AMYGDALINE IN ITS NATURAL FORM.
FR2201288A1 (en) 5-Halo-2-benzofuryl acrylic acids - monomers for prepn of polyacrylates and interms for medicaments
FR2054955A5 (en) Antimicrobial n-subst 6,7-methylenedioxy-4- - quinolone derivs prepn
NL7508741A (en) Oxoalkyl esters of vincamine acids - and their pharm. acceptable salts for use in medicine
KR790000509B1 (en) Process for production of 3b(4'-oxo-a-l-rhamnosyl)-14b-hydroxy-bufa-4,20,22-trienolide
ES373432A1 (en) Procedure for the preparation of new derivatives of the acid range-trimethylamine - beta - hydroxibutirico with therapeutic properties. (Machine-translation by Google Translate, not legally binding)
GB939905A (en) A process for preparing a penillic acid and salts thereof

Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse