FR2275209A1 - Oxoalkyl esters of vincamine acids - and their pharm. acceptable salts for use in medicine - Google Patents

Oxoalkyl esters of vincamine acids - and their pharm. acceptable salts for use in medicine

Info

Publication number
FR2275209A1
FR2275209A1 FR7421581A FR7421581A FR2275209A1 FR 2275209 A1 FR2275209 A1 FR 2275209A1 FR 7421581 A FR7421581 A FR 7421581A FR 7421581 A FR7421581 A FR 7421581A FR 2275209 A1 FR2275209 A1 FR 2275209A1
Authority
FR
France
Prior art keywords
vincamine
pharm
medicine
acids
acceptable salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7421581A
Other languages
French (fr)
Other versions
FR2275209B1 (en
Inventor
Don Pierre Rene Luc Giudicelli
Henry Najer
Yves Robert Alain Pascal
Regis Dupont
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7421581A priority Critical patent/FR2275209A1/en
Priority to BE158285A priority patent/BE831350A/en
Publication of FR2275209A1 publication Critical patent/FR2275209A1/en
Application granted granted Critical
Publication of FR2275209B1 publication Critical patent/FR2275209B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Abstract

vincamine derivs. of formula (I) and their acid-addn. salts are new: (where R1 is H or OH; R2 singly is OH; or R1+R2 may be an additional bond; R3 and R4 are H or Me; R5 is 1-4 C alkyl). Pref. 2-oxopropyl desoxyvincaminate, 2-oxopropyl apovincaminate and their oxalates, and compsns. of (I) with ascorbic acid and its salts, and with the equimolar complexes of ascorbic acid with nicotinamide or with pyridoxine, have use in treating cardiocirculatory and cerebrovascular insufficiencies.
FR7421581A 1974-06-21 1974-06-21 Oxoalkyl esters of vincamine acids - and their pharm. acceptable salts for use in medicine Granted FR2275209A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR7421581A FR2275209A1 (en) 1974-06-21 1974-06-21 Oxoalkyl esters of vincamine acids - and their pharm. acceptable salts for use in medicine
BE158285A BE831350A (en) 1974-06-21 1975-07-14 NEW KETONIC ESTERS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7421581A FR2275209A1 (en) 1974-06-21 1974-06-21 Oxoalkyl esters of vincamine acids - and their pharm. acceptable salts for use in medicine

Publications (2)

Publication Number Publication Date
FR2275209A1 true FR2275209A1 (en) 1976-01-16
FR2275209B1 FR2275209B1 (en) 1978-08-11

Family

ID=9140347

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7421581A Granted FR2275209A1 (en) 1974-06-21 1974-06-21 Oxoalkyl esters of vincamine acids - and their pharm. acceptable salts for use in medicine

Country Status (2)

Country Link
BE (1) BE831350A (en)
FR (1) FR2275209A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0052238A1 (en) * 1980-11-14 1982-05-26 MEDEA RESEARCH S.r.l. A new vincamine derivative, a method for its preparation and pharmaceutical compositions containing it

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60023125T2 (en) 1999-03-08 2006-06-22 University Of Manitoba, Winnipeg PYRIDOXAL ANALOGUE FOR THE TREATMENT OF DISORDERS RELEASED BY A VITAMIN B6 LACK
AU5840200A (en) 1999-07-13 2001-01-30 Medicure Inc. Treatment of diabetes and related pathologies
WO2001013900A2 (en) 1999-08-24 2001-03-01 Medicure International Inc. Compositions for the treatment of cardiovascular diseases containing pyridoxal compounds and cardiovascular compounds
JP2003525303A (en) 2000-02-29 2003-08-26 メディキュア インターナショナル インコーポレイテッド Cardioprotective phosphonates and malonates
JP2003528146A (en) 2000-03-28 2003-09-24 メディキュア インターナショナル インコーポレイテッド Treatment of cerebrovascular disease
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
US6897228B2 (en) 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
ATE364595T1 (en) 2000-07-07 2007-07-15 Medicure Int Inc PYRIDOXINE AND PYRIDOXAL ANALOGS AS CARDIOVASCULAR THERAPEUTICS
AU2005304220A1 (en) 2004-10-28 2006-05-18 Medicure International Inc. Dual antiplatelet/anticoagulant pyridoxine analogs

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0052238A1 (en) * 1980-11-14 1982-05-26 MEDEA RESEARCH S.r.l. A new vincamine derivative, a method for its preparation and pharmaceutical compositions containing it

Also Published As

Publication number Publication date
BE831350A (en) 1976-01-14
FR2275209B1 (en) 1978-08-11

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Legal Events

Date Code Title Description
ST Notification of lapse