NL7508741A - Oxoalkyl esters of vincamine acids - and their pharm. acceptable salts for use in medicine - Google Patents

Oxoalkyl esters of vincamine acids - and their pharm. acceptable salts for use in medicine

Info

Publication number
NL7508741A
NL7508741A NL7508741A NL7508741A NL7508741A NL 7508741 A NL7508741 A NL 7508741A NL 7508741 A NL7508741 A NL 7508741A NL 7508741 A NL7508741 A NL 7508741A NL 7508741 A NL7508741 A NL 7508741A
Authority
NL
Netherlands
Prior art keywords
vincamine
pharm
medicine
acids
acceptable salts
Prior art date
Application number
NL7508741A
Other languages
Dutch (nl)
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Priority to NL7508741A priority Critical patent/NL7508741A/en
Publication of NL7508741A publication Critical patent/NL7508741A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

vincamine derivs. of formula (I) and their acid-addn. salts are new: (where R1 is H or OH; R2 singly is OH; or R1+R2 may be an additional bond; R3 and R4 are H or Me; R5 is 1-4 C alkyl). Pref. 2-oxopropyl desoxyvincaminate, 2-oxopropyl apovincaminate and their oxalates, and compsns. of (I) with ascorbic acid and its salts, and with the equimolar complexes of ascorbic acid with nicotinamide or with pyridoxine, have use in treating cardiocirculatory and cerebrovascular insufficiencies.
NL7508741A 1975-07-22 1975-07-22 Oxoalkyl esters of vincamine acids - and their pharm. acceptable salts for use in medicine NL7508741A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7508741A NL7508741A (en) 1975-07-22 1975-07-22 Oxoalkyl esters of vincamine acids - and their pharm. acceptable salts for use in medicine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7508741A NL7508741A (en) 1975-07-22 1975-07-22 Oxoalkyl esters of vincamine acids - and their pharm. acceptable salts for use in medicine

Publications (1)

Publication Number Publication Date
NL7508741A true NL7508741A (en) 1977-01-25

Family

ID=19824193

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7508741A NL7508741A (en) 1975-07-22 1975-07-22 Oxoalkyl esters of vincamine acids - and their pharm. acceptable salts for use in medicine

Country Status (1)

Country Link
NL (1) NL7508741A (en)

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