FR2051513A1 - Sulphonylurea derivs for reduction of sugar - level in blood of diabetics - Google Patents

Sulphonylurea derivs for reduction of sugar - level in blood of diabetics

Info

Publication number
FR2051513A1
FR2051513A1 FR7016861A FR7016861A FR2051513A1 FR 2051513 A1 FR2051513 A1 FR 2051513A1 FR 7016861 A FR7016861 A FR 7016861A FR 7016861 A FR7016861 A FR 7016861A FR 2051513 A1 FR2051513 A1 FR 2051513A1
Authority
FR
France
Prior art keywords
alkyl
derivs
alkoxyalkyl
dihydro
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7016861A
Other languages
French (fr)
Other versions
FR2051513B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Terapeutisk Laboratorium AS
Original Assignee
Novo Terapeutisk Laboratorium AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Terapeutisk Laboratorium AS filed Critical Novo Terapeutisk Laboratorium AS
Publication of FR2051513A1 publication Critical patent/FR2051513A1/en
Application granted granted Critical
Publication of FR2051513B1 publication Critical patent/FR2051513B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Derivs. are of formula : and their salts (where R1 is lower-alkyl, -alkenyl or -alkoxyalkyl, lower phenylalkyl, lower cyclohexylalkyl, cycloheptyl and cyclooctyl-methyl, cyclohexyl, lower cyclohexenylalkyl, 5-8C cycloalkyl, endoalkylenecyclohexyl, -cyclohexenyl, -cyclohexylmethyl, or -cyclohexenylmethyl with 1 or 2 C in the endo-alkylene chain; (di) or tri-) lower alkyl cyclohexyl, (di) lower alkyl cyclohexenyl; lower alkyl cyclohexyl, adamantyl or nortricyclyl; Y is a straight or branched chain 2-4C hydrocarbon, pref. -CH2-CH2-; R2 is H, lower alkyl, -alkoxyalkyl or -alkenyl, -alkoxy, alkenoxy, -thioalkoxy, -alkoxyalkoxy or benzyloxy, halogen or trifluoromethyl; U is a 2-4C chain contg. (dihydro)benzofuran, (dihydro) benzopyran, dihydro- or tetrahydro-benzoxepin; R3 and R4 are H, lower-alkyl, -alkoxyalkyl, -alkenyl, -alkoxy, -alkenoxy, phenyl or benzyloxy).
FR7016861A 1969-05-09 1970-05-08 Sulphonylurea derivs for reduction of sugar - level in blood of diabetics Granted FR2051513A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2388869 1969-05-09
GB4276369 1969-08-27
GB5743469 1969-11-24

Publications (2)

Publication Number Publication Date
FR2051513A1 true FR2051513A1 (en) 1971-04-09
FR2051513B1 FR2051513B1 (en) 1974-06-14

Family

ID=27258272

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7016861A Granted FR2051513A1 (en) 1969-05-09 1970-05-08 Sulphonylurea derivs for reduction of sugar - level in blood of diabetics

Country Status (12)

Country Link
JP (1) JPS4945868B1 (en)
CA (1) CA954525A (en)
CH (1) CH557810A (en)
DE (2) DE2065185A1 (en)
DK (1) DK128244C (en)
ES (5) ES379494A1 (en)
FI (1) FI54476C (en)
FR (1) FR2051513A1 (en)
IE (1) IE34211B1 (en)
NL (1) NL7006726A (en)
NO (1) NO130825C (en)
SE (1) SE374743B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2189029A1 (en) * 1972-05-26 1974-01-25 Hoechst Ag
EP0101670A2 (en) * 1982-08-23 1984-02-29 Ciba-Geigy Ag Process for the preparation of herbicides and plant growth regulating sulfonyl ureas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1031088A (en) * 1964-04-16 1966-05-25 Hoechst Ag Benzenesulphonyl-ureas and process for their manufacture
AT262311B (en) * 1964-10-16 1968-06-10 Hoechst Ag Process for the preparation of new benzenesulfonylureas and their salts

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2189029A1 (en) * 1972-05-26 1974-01-25 Hoechst Ag
EP0101670A2 (en) * 1982-08-23 1984-02-29 Ciba-Geigy Ag Process for the preparation of herbicides and plant growth regulating sulfonyl ureas
EP0101670A3 (en) * 1982-08-23 1985-05-29 Ciba-Geigy Ag Process for the preparation of herbicides and plant growth regulating sulfonyl ureas

Also Published As

Publication number Publication date
JPS4945868B1 (en) 1974-12-06
SE374743B (en) 1975-03-17
FR2051513B1 (en) 1974-06-14
IE34211L (en) 1970-11-09
ES391916A1 (en) 1973-07-01
DK128244B (en) 1974-03-25
CA954525A (en) 1974-09-10
FI54476C (en) 1978-12-11
CH557810A (en) 1975-01-15
ES391913A1 (en) 1973-07-01
NL7006726A (en) 1970-11-11
DE2021828C3 (en) 1981-12-10
DE2065185A1 (en) 1973-02-08
DE2021828A1 (en) 1970-11-19
ES379494A1 (en) 1973-12-01
FI54476B (en) 1978-08-31
DE2021828B2 (en) 1974-02-21
NO130825B (en) 1974-11-11
ES391915A1 (en) 1973-07-01
DK128244C (en) 1981-02-23
ES391914A1 (en) 1973-07-01
NO130825C (en) 1975-02-19
IE34211B1 (en) 1975-03-05

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Legal Events

Date Code Title Description
ST Notification of lapse