BE750151A - Sulphonylurea derivs for reduction of sugar - level in blood of diabetics - Google Patents

Sulphonylurea derivs for reduction of sugar - level in blood of diabetics

Info

Publication number
BE750151A
BE750151A BE750151DA BE750151A BE 750151 A BE750151 A BE 750151A BE 750151D A BE750151D A BE 750151DA BE 750151 A BE750151 A BE 750151A
Authority
BE
Belgium
Prior art keywords
alkyl
derivs
alkoxyalkyl
dihydro
alkenyl
Prior art date
Application number
Other languages
French (fr)
Inventor
H Christensen
B F Lundt
F C Gronvald
W Andersen
Original Assignee
Novo Terapeutisk Labor As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Terapeutisk Labor As filed Critical Novo Terapeutisk Labor As
Publication of BE750151A publication Critical patent/BE750151A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivs. are of formula : and their salts (where R1 is lower-alkyl, -alkenyl or -alkoxyalkyl, lower phenylalkyl, lower cyclohexylalkyl, cycloheptyl and cyclooctyl-methyl, cyclohexyl, lower cyclohexenylalkyl, 5-8C cycloalkyl, endoalkylenecyclohexyl, -cyclohexenyl, -cyclohexylmethyl, or -cyclohexenylmethyl with 1 or 2 C in the endo-alkylene chain; (di) or tri-) lower alkyl cyclohexyl, (di) lower alkyl cyclohexenyl; lower alkyl cyclohexyl, adamantyl or nortricyclyl; Y is a straight or branched chain 2-4C hydrocarbon, pref. -CH2-CH2-; R2 is H, lower alkyl, -alkoxyalkyl or -alkenyl, -alkoxy, alkenoxy, -thioalkoxy, -alkoxyalkoxy or benzyloxy, halogen or trifluoromethyl; U is a 2-4C chain contg. (dihydro)benzofuran, (dihydro) benzopyran, dihydro- or tetrahydro-benzoxepin; R3 and R4 are H, lower-alkyl, -alkoxyalkyl, -alkenyl, -alkoxy, -alkenoxy, phenyl or benzyloxy).
BE750151D 1969-05-09 1970-05-08 Sulphonylurea derivs for reduction of sugar - level in blood of diabetics BE750151A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2388869 1969-05-09
GB4276369 1969-08-27

Publications (1)

Publication Number Publication Date
BE750151A true BE750151A (en) 1970-11-09

Family

ID=26256777

Family Applications (1)

Application Number Title Priority Date Filing Date
BE750151D BE750151A (en) 1969-05-09 1970-05-08 Sulphonylurea derivs for reduction of sugar - level in blood of diabetics

Country Status (1)

Country Link
BE (1) BE750151A (en)

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: NOVO TERAPEUTISK LABORATORIUM A/S

Effective date: 19840508