ES391916A1 - A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES391916A1
ES391916A1 ES391916A ES391916A ES391916A1 ES 391916 A1 ES391916 A1 ES 391916A1 ES 391916 A ES391916 A ES 391916A ES 391916 A ES391916 A ES 391916A ES 391916 A1 ES391916 A1 ES 391916A1
Authority
ES
Spain
Prior art keywords
cyclohexyl
endoalkylene
cyclohexenyl
alcohol
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES391916A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Terapeutisk Laboratorium AS
Original Assignee
Novo Terapeutisk Laboratorium AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Terapeutisk Laboratorium AS filed Critical Novo Terapeutisk Laboratorium AS
Publication of ES391916A1 publication Critical patent/ES391916A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A method of preparing new hypoglycemic sulfonylurea compounds of the general formula. **(See formula)** wherein R1 is selected from the group consisting of: (a) lower alcohol, lower alkenyl, and lower alkoxyalkoyl; (b) lower phenialcohyl; (c) cyclohexylalkyl lower, cycloheptylmethyl, cycloheptylethyl and cyclooctylmethyl; (dicyclohexenyl and cyclohexenyl lower alkyl; (e) cycloalkyl having 5 to 8 carbon atoms; (f) endoalkylene-cyclohexyl, endoalkylene-cyclohexenyl, endoalkylene-cyclohexylmethyl and endoalkylene-cyclohexenylmethyl having one or two carbonyl chain atoms; (g) lower alcohol-cyclohexyl, dialkoyl lower-cyclohexyl, trialkoyl lower-cyclohexyl, lower alcohol-cyclohexenyl and dialkoyl lower-cyclohexenyl (h) lower alkoxy-cyclohexyl and (i) adamantyl and nortricyclyl; Y represents a straight or branched hydrocarbon chain from 2 to 4 carbon atoms, preferably -CH2 CH2-; R2 is selected from the group consisting of (a) hydrogen; (b) lower alcohol, lower alkoxyalkoyl and lower alkenyl; (c) lower alkoxy, lower alkenoxy, lower alcoholylthio, lower alkoxyalkoxy and benzoyloxy and (d) halogen and trifluoromethyl; U is a chain of 2 to 4 carbon atoms contained in the residues benzofuran, dihydrobenzofuran -benzopyran; dihydrobenzopyran-, dihydro- or tetrahydroben-zoxepin-, and each of R3 and R4 is selected from the group consisting of (a) hydrogen; (b) lower alcohol, lower alcohol, lower alkenyl and phenyl and (c) lower alkoxy, lower alkenoxy and benzyloxy, or R3 and R4 may together form a double bond with an oxygen atom outside the heterocyclic ring, or salts thereof Physiologically acceptable, characterized by hydrolyzing the benzenesulfonyl-isourea ethers, benzenesulfonyl-isothiourea ethers, benzenesulfonylparabamic acid derivatives, benzenesulfonylguanidines, or correspondingly substituted benzenesulfonyl-haloformic amidines. (Machine-translation by Google Translate, not legally binding)
ES391916A 1969-05-09 1971-06-04 A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding) Expired ES391916A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2388869 1969-05-09
GB4276369 1969-08-27
GB5743469 1969-11-24

Publications (1)

Publication Number Publication Date
ES391916A1 true ES391916A1 (en) 1973-07-01

Family

ID=27258272

Family Applications (5)

Application Number Title Priority Date Filing Date
ES379494A Expired ES379494A1 (en) 1969-05-09 1970-05-09 A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding)
ES391913A Expired ES391913A1 (en) 1969-05-09 1971-06-04 A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding)
ES391915A Expired ES391915A1 (en) 1969-05-09 1971-06-04 A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding)
ES391914A Expired ES391914A1 (en) 1969-05-09 1971-06-04 A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding)
ES391916A Expired ES391916A1 (en) 1969-05-09 1971-06-04 A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding)

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES379494A Expired ES379494A1 (en) 1969-05-09 1970-05-09 A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding)
ES391913A Expired ES391913A1 (en) 1969-05-09 1971-06-04 A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding)
ES391915A Expired ES391915A1 (en) 1969-05-09 1971-06-04 A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding)
ES391914A Expired ES391914A1 (en) 1969-05-09 1971-06-04 A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding)

Country Status (12)

Country Link
JP (1) JPS4945868B1 (en)
CA (1) CA954525A (en)
CH (1) CH557810A (en)
DE (2) DE2021828C3 (en)
DK (1) DK128244C (en)
ES (5) ES379494A1 (en)
FI (1) FI54476C (en)
FR (1) FR2051513A1 (en)
IE (1) IE34211B1 (en)
NL (1) NL7006726A (en)
NO (1) NO130825C (en)
SE (1) SE374743B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2225544A1 (en) * 1972-05-26 1973-12-13 Hoechst Ag BENZENE SULFONYL URUBE AND METHOD FOR MANUFACTURING IT
DE3375916D1 (en) * 1982-08-23 1988-04-14 Ciba Geigy Ag Process for the preparation of herbicides and plant growth regulating sulfonyl ureas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1031088A (en) * 1964-04-16 1966-05-25 Hoechst Ag Benzenesulphonyl-ureas and process for their manufacture
AT262311B (en) * 1964-10-16 1968-06-10 Hoechst Ag Process for the preparation of new benzenesulfonylureas and their salts

Also Published As

Publication number Publication date
ES391914A1 (en) 1973-07-01
ES391915A1 (en) 1973-07-01
IE34211L (en) 1970-11-09
FI54476C (en) 1978-12-11
ES391913A1 (en) 1973-07-01
DE2021828A1 (en) 1970-11-19
DK128244C (en) 1981-02-23
NL7006726A (en) 1970-11-11
JPS4945868B1 (en) 1974-12-06
ES379494A1 (en) 1973-12-01
SE374743B (en) 1975-03-17
DK128244B (en) 1974-03-25
DE2021828C3 (en) 1981-12-10
CA954525A (en) 1974-09-10
IE34211B1 (en) 1975-03-05
FI54476B (en) 1978-08-31
FR2051513A1 (en) 1971-04-09
CH557810A (en) 1975-01-15
DE2065185A1 (en) 1973-02-08
NO130825B (en) 1974-11-11
DE2021828B2 (en) 1974-02-21
FR2051513B1 (en) 1974-06-14
NO130825C (en) 1975-02-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19840512