ES391916A1 - A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES391916A1 ES391916A1 ES391916A ES391916A ES391916A1 ES 391916 A1 ES391916 A1 ES 391916A1 ES 391916 A ES391916 A ES 391916A ES 391916 A ES391916 A ES 391916A ES 391916 A1 ES391916 A1 ES 391916A1
- Authority
- ES
- Spain
- Prior art keywords
- cyclohexyl
- endoalkylene
- cyclohexenyl
- alcohol
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A method of preparing new hypoglycemic sulfonylurea compounds of the general formula. **(See formula)** wherein R1 is selected from the group consisting of: (a) lower alcohol, lower alkenyl, and lower alkoxyalkoyl; (b) lower phenialcohyl; (c) cyclohexylalkyl lower, cycloheptylmethyl, cycloheptylethyl and cyclooctylmethyl; (dicyclohexenyl and cyclohexenyl lower alkyl; (e) cycloalkyl having 5 to 8 carbon atoms; (f) endoalkylene-cyclohexyl, endoalkylene-cyclohexenyl, endoalkylene-cyclohexylmethyl and endoalkylene-cyclohexenylmethyl having one or two carbonyl chain atoms; (g) lower alcohol-cyclohexyl, dialkoyl lower-cyclohexyl, trialkoyl lower-cyclohexyl, lower alcohol-cyclohexenyl and dialkoyl lower-cyclohexenyl (h) lower alkoxy-cyclohexyl and (i) adamantyl and nortricyclyl; Y represents a straight or branched hydrocarbon chain from 2 to 4 carbon atoms, preferably -CH2 CH2-; R2 is selected from the group consisting of (a) hydrogen; (b) lower alcohol, lower alkoxyalkoyl and lower alkenyl; (c) lower alkoxy, lower alkenoxy, lower alcoholylthio, lower alkoxyalkoxy and benzoyloxy and (d) halogen and trifluoromethyl; U is a chain of 2 to 4 carbon atoms contained in the residues benzofuran, dihydrobenzofuran -benzopyran; dihydrobenzopyran-, dihydro- or tetrahydroben-zoxepin-, and each of R3 and R4 is selected from the group consisting of (a) hydrogen; (b) lower alcohol, lower alcohol, lower alkenyl and phenyl and (c) lower alkoxy, lower alkenoxy and benzyloxy, or R3 and R4 may together form a double bond with an oxygen atom outside the heterocyclic ring, or salts thereof Physiologically acceptable, characterized by hydrolyzing the benzenesulfonyl-isourea ethers, benzenesulfonyl-isothiourea ethers, benzenesulfonylparabamic acid derivatives, benzenesulfonylguanidines, or correspondingly substituted benzenesulfonyl-haloformic amidines. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2388869 | 1969-05-09 | ||
GB4276369 | 1969-08-27 | ||
GB5743469 | 1969-11-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES391916A1 true ES391916A1 (en) | 1973-07-01 |
Family
ID=27258272
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES379494A Expired ES379494A1 (en) | 1969-05-09 | 1970-05-09 | A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding) |
ES391914A Expired ES391914A1 (en) | 1969-05-09 | 1971-06-04 | A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding) |
ES391916A Expired ES391916A1 (en) | 1969-05-09 | 1971-06-04 | A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding) |
ES391915A Expired ES391915A1 (en) | 1969-05-09 | 1971-06-04 | A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding) |
ES391913A Expired ES391913A1 (en) | 1969-05-09 | 1971-06-04 | A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES379494A Expired ES379494A1 (en) | 1969-05-09 | 1970-05-09 | A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding) |
ES391914A Expired ES391914A1 (en) | 1969-05-09 | 1971-06-04 | A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES391915A Expired ES391915A1 (en) | 1969-05-09 | 1971-06-04 | A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding) |
ES391913A Expired ES391913A1 (en) | 1969-05-09 | 1971-06-04 | A procedure to prepare new compounds of sulfonilurea or its salts. (Machine-translation by Google Translate, not legally binding) |
Country Status (12)
Country | Link |
---|---|
JP (1) | JPS4945868B1 (en) |
CA (1) | CA954525A (en) |
CH (1) | CH557810A (en) |
DE (2) | DE2021828C3 (en) |
DK (1) | DK128244C (en) |
ES (5) | ES379494A1 (en) |
FI (1) | FI54476C (en) |
FR (1) | FR2051513A1 (en) |
IE (1) | IE34211B1 (en) |
NL (1) | NL7006726A (en) |
NO (1) | NO130825C (en) |
SE (1) | SE374743B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2225544A1 (en) * | 1972-05-26 | 1973-12-13 | Hoechst Ag | BENZENE SULFONYL URUBE AND METHOD FOR MANUFACTURING IT |
DE3375916D1 (en) * | 1982-08-23 | 1988-04-14 | Ciba Geigy Ag | Process for the preparation of herbicides and plant growth regulating sulfonyl ureas |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1031088A (en) * | 1964-04-16 | 1966-05-25 | Hoechst Ag | Benzenesulphonyl-ureas and process for their manufacture |
AT262311B (en) * | 1964-10-16 | 1968-06-10 | Hoechst Ag | Process for the preparation of new benzenesulfonylureas and their salts |
-
1970
- 1970-04-27 IE IE52970A patent/IE34211B1/en unknown
- 1970-04-28 CA CA081,360A patent/CA954525A/en not_active Expired
- 1970-05-05 DE DE19702021828 patent/DE2021828C3/en not_active Expired
- 1970-05-05 SE SE620870A patent/SE374743B/xx unknown
- 1970-05-05 DK DK225970A patent/DK128244C/en active
- 1970-05-05 DE DE19702065185 patent/DE2065185A1/en active Pending
- 1970-05-06 CH CH683570A patent/CH557810A/en not_active IP Right Cessation
- 1970-05-06 NO NO173170A patent/NO130825C/no unknown
- 1970-05-08 JP JP3871870A patent/JPS4945868B1/ja active Pending
- 1970-05-08 NL NL7006726A patent/NL7006726A/xx not_active Application Discontinuation
- 1970-05-08 FI FI129170A patent/FI54476C/en active
- 1970-05-08 FR FR7016861A patent/FR2051513A1/en active Granted
- 1970-05-09 ES ES379494A patent/ES379494A1/en not_active Expired
-
1971
- 1971-06-04 ES ES391914A patent/ES391914A1/en not_active Expired
- 1971-06-04 ES ES391916A patent/ES391916A1/en not_active Expired
- 1971-06-04 ES ES391915A patent/ES391915A1/en not_active Expired
- 1971-06-04 ES ES391913A patent/ES391913A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE2021828A1 (en) | 1970-11-19 |
IE34211B1 (en) | 1975-03-05 |
DE2021828C3 (en) | 1981-12-10 |
ES391913A1 (en) | 1973-07-01 |
NL7006726A (en) | 1970-11-11 |
FI54476C (en) | 1978-12-11 |
DE2065185A1 (en) | 1973-02-08 |
NO130825B (en) | 1974-11-11 |
CA954525A (en) | 1974-09-10 |
FR2051513B1 (en) | 1974-06-14 |
ES391914A1 (en) | 1973-07-01 |
SE374743B (en) | 1975-03-17 |
ES391915A1 (en) | 1973-07-01 |
JPS4945868B1 (en) | 1974-12-06 |
ES379494A1 (en) | 1973-12-01 |
NO130825C (en) | 1975-02-19 |
DE2021828B2 (en) | 1974-02-21 |
DK128244C (en) | 1981-02-23 |
IE34211L (en) | 1970-11-09 |
CH557810A (en) | 1975-01-15 |
FI54476B (en) | 1978-08-31 |
FR2051513A1 (en) | 1971-04-09 |
DK128244B (en) | 1974-03-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19840512 |