FR2035813A1 - 6-dialkylaminoacetyl-gluconolactone salts - Google Patents

6-dialkylaminoacetyl-gluconolactone salts

Info

Publication number
FR2035813A1
FR2035813A1 FR6936952A FR6936952A FR2035813A1 FR 2035813 A1 FR2035813 A1 FR 2035813A1 FR 6936952 A FR6936952 A FR 6936952A FR 6936952 A FR6936952 A FR 6936952A FR 2035813 A1 FR2035813 A1 FR 2035813A1
Authority
FR
France
Prior art keywords
salts
glucono
pref
lactone
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR6936952A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of FR2035813A1 publication Critical patent/FR2035813A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/02—Alkyl or cycloalkyl ethers
    • C08B11/04—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals
    • C08B11/10—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals
    • C08B11/12—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals substituted with carboxylic radicals, e.g. carboxymethylcellulose [CMC]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B3/00—Preparation of cellulose esters of organic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New salts are addition salts of 6-di(lower alkyl)aminoacetyl-glucono-1,4-lactone (I): (where R1 and R2 are lower alkyl) with cellulose acetate phthalate, carboxymethylcellulose and alginic acid. Pref. prepd. by reacting (I) hydrohalide (pref. hydro chloride) with an alkali metal salt of cellulose acetate phthalate, carboxymethylcellulose or alginic acid in an organic solvent (e.g. MeOH, EtOH, Me2CO, THF). Hydrohalide salts of (I) are prepd. by reacting glucono 1,4-lactone (II) with phenyl boronate or its anhydride, reacting the resulting glucono-1,4 lactone 3,5-phenylboronate (III) with a hydrohalide (pref. the hydrochloride) of HOOCCH2NR1R2 (IV) in the presence of a carbodiimide cpd., and reacting the resulting 6-N,N-di(lower alkyl)aminoacetyl-glucono-1,4-lactone 3,5-phenylboronate (V) with a lower alkylenediol (pref. 1,2- or 1,3- propanediol or ethylene glycol). The salts have higher stability and are less hydroscopic than the free base and are active against cardiovascular disease, rheumatism, anginous dys pnoea, cyanosis and cerebral sclerosis.
FR6936952A 1968-10-28 1969-10-28 6-dialkylaminoacetyl-gluconolactone salts Withdrawn FR2035813A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7792368 1968-10-28
JP9424668 1968-12-24

Publications (1)

Publication Number Publication Date
FR2035813A1 true FR2035813A1 (en) 1970-12-24

Family

ID=26418973

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6936952A Withdrawn FR2035813A1 (en) 1968-10-28 1969-10-28 6-dialkylaminoacetyl-gluconolactone salts

Country Status (2)

Country Link
DE (1) DE1953913A1 (en)
FR (1) FR2035813A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT85759B (en) * 1987-09-21 1990-07-31 Tecnimede Sociedade Tecnico Medicinal Sa PROCESS FOR THE PREPARATION OF DIMETHYLGLYCYL-GLUCONIC ACID AND ITS SALTS

Also Published As

Publication number Publication date
DE1953913A1 (en) 1970-04-30

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