FR2034448A1 - Benzoxazocine derivs cns active - Google Patents
Benzoxazocine derivs cns activeInfo
- Publication number
- FR2034448A1 FR2034448A1 FR7011119A FR7011119A FR2034448A1 FR 2034448 A1 FR2034448 A1 FR 2034448A1 FR 7011119 A FR7011119 A FR 7011119A FR 7011119 A FR7011119 A FR 7011119A FR 2034448 A1 FR2034448 A1 FR 2034448A1
- Authority
- FR
- France
- Prior art keywords
- tetrahydro
- hydrogen
- soln
- chloroform
- dimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Method for the prepn. of 3,4,5,6-tetrahydro-2,6-methano-2H-1,5-benzoxazocine derivs. of the general formula (I) and acid addn. salts and N-oxides of (I) R1 = hydrogen or alkyl (1-6C) R2 = hydrogen, opt. substd. hydrocarbon (1 to 24C) or acyl R3 = hydrogen, opt. substd. aliphatic or arylaliphatic hydrocarbon (1 to 24C) X = hydrogen or hydroxy, or an ester or ether deriv. of hydroxy The cpds. have C.N.S. activity esp. analgetic activity and have activity on the heart- and blood-fat system. A soln. of 0.4 g. of a mixture of 2-(1,4-dimethyl-1,2,5,6-tetrahydro-2-pyridinyl)-resorcinol and 2-(1,4-dimethyl-1,2,3,6-tetrahydro-2-pyridinyl)-resorcinol was boiled for 1 hr. on a water bath with 10 ml. conc. hydrochloric acid. The soln. was cooled and neutralised to pH 7 with 10% NaOH soln. The mixture was extracted with chloroform (2 X 100 ml) and the extract washed with satd. NaCl soln. and after drying, evaporated to dryness. The residual brown gum was chromatographed on a column of silica gel (20 g.) eluting with chloroform, chloroform/methanol and finally with methanol, the methanol eluate on evaporation yielding 0.18 g. 2,5-dimethyl-3,4,5,6-tetrahydro-2,6-methano-2H-1,5-benzoxazocin -7-ol, as a dark brown foam.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70744868A | 1968-02-23 | 1968-02-23 | |
FR6904419A FR2002482A1 (en) | 1968-02-23 | 1969-02-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2034448A1 true FR2034448A1 (en) | 1970-12-11 |
FR2034448B1 FR2034448B1 (en) | 1974-08-09 |
Family
ID=26214855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7011119A Granted FR2034448A1 (en) | 1968-02-23 | 1970-03-27 | Benzoxazocine derivs cns active |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2034448A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2518093A2 (en) * | 1980-12-15 | 1983-06-17 | Roussel Uclaf | 3-1,2,5,6-Tetra:hydro-1-substd.-3-pyridyl phenol derivs. - dopaminergic agonists and/or antagonists and antiemetics, used to treat Parkinson's disease, psychic disorders etc. |
-
1970
- 1970-03-27 FR FR7011119A patent/FR2034448A1/en active Granted
Non-Patent Citations (1)
Title |
---|
NEANT * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2518093A2 (en) * | 1980-12-15 | 1983-06-17 | Roussel Uclaf | 3-1,2,5,6-Tetra:hydro-1-substd.-3-pyridyl phenol derivs. - dopaminergic agonists and/or antagonists and antiemetics, used to treat Parkinson's disease, psychic disorders etc. |
Also Published As
Publication number | Publication date |
---|---|
FR2034448B1 (en) | 1974-08-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |