FR18C1038I2 - Procede de production et de purification d'alpha-mannosidase lysosomale recombinante - Google Patents

Procede de production et de purification d'alpha-mannosidase lysosomale recombinante

Info

Publication number
FR18C1038I2
FR18C1038I2 FR18C1038C FR18C1038C FR18C1038I2 FR 18C1038 I2 FR18C1038 I2 FR 18C1038I2 FR 18C1038 C FR18C1038 C FR 18C1038C FR 18C1038 C FR18C1038 C FR 18C1038C FR 18C1038 I2 FR18C1038 I2 FR 18C1038I2
Authority
FR
France
Prior art keywords
mannosidase
purification
production
recombinant lysosomal
lysosomal alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR18C1038C
Other languages
English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiesi Farmaceutici SpA
Original Assignee
Chiesi Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici SpA filed Critical Chiesi Farmaceutici SpA
Publication of FR18C1038I1 publication Critical patent/FR18C1038I1/fr
Application granted granted Critical
Publication of FR18C1038I2 publication Critical patent/FR18C1038I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2477—Hemicellulases not provided in a preceding group
    • C12N9/2488—Mannanases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01024—Alpha-mannosidase (3.2.1.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Obesity (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
FR18C1038C 2010-02-24 2018-09-14 Procede de production et de purification d'alpha-mannosidase lysosomale recombinante Active FR18C1038I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30758710P 2010-02-24 2010-02-24
DKPA201070067 2010-02-24
PCT/DK2011/050054 WO2011103877A1 (en) 2010-02-24 2011-02-23 Process for production and purification of recombinant lysosomal alpha-mannosidase

Publications (2)

Publication Number Publication Date
FR18C1038I1 FR18C1038I1 (zh) 2018-11-02
FR18C1038I2 true FR18C1038I2 (fr) 2019-10-11

Family

ID=43920349

Family Applications (1)

Application Number Title Priority Date Filing Date
FR18C1038C Active FR18C1038I2 (fr) 2010-02-24 2018-09-14 Procede de production et de purification d'alpha-mannosidase lysosomale recombinante

Country Status (25)

Country Link
US (3) US8974780B2 (zh)
EP (2) EP3281636B1 (zh)
JP (1) JP6021647B2 (zh)
KR (1) KR101856260B1 (zh)
CN (1) CN102834111B (zh)
AU (1) AU2011220163B2 (zh)
BR (1) BR112012020934B1 (zh)
CA (1) CA2790786C (zh)
CY (2) CY1123438T1 (zh)
DK (2) DK2538968T3 (zh)
EA (1) EA022220B1 (zh)
ES (1) ES2652330T3 (zh)
FR (1) FR18C1038I2 (zh)
HK (1) HK1179869A1 (zh)
HR (1) HRP20171736T1 (zh)
HU (2) HUE037943T2 (zh)
LT (2) LT2538968T (zh)
NL (1) NL300948I2 (zh)
NO (2) NO2538968T3 (zh)
NZ (1) NZ601790A (zh)
PL (2) PL3281636T3 (zh)
PT (1) PT2538968T (zh)
RS (1) RS60983B1 (zh)
SI (2) SI2538968T1 (zh)
WO (1) WO2011103877A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9169331B2 (en) 2012-12-21 2015-10-27 Dionex Corporation Separation of glycans by mixed-mode liquid chromatography
US9310344B2 (en) 2013-06-14 2016-04-12 Dionex Corporation HILIC/anion-exchange/cation-exchange multimodal media
AR095196A1 (es) * 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
CN111100196B (zh) * 2019-11-08 2021-07-13 上海交通大学 一种生物活性多肽qilsvpgwtysr及其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL63327A (en) * 1981-07-16 1985-11-29 Yeda Res & Dev Production of interferon beta1 and alpha-phage recombinants for its production in host bacteria
US5705364A (en) * 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
JP4320870B2 (ja) 1999-10-18 2009-08-26 住友化学株式会社 （＋）−トランス第一菊酸の製造方法
GB0007651D0 (en) * 2000-03-29 2000-05-17 Ascorbex Ltd Gene sequence
US7138262B1 (en) * 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
AU2002317701A1 (en) 2001-06-07 2002-12-16 Hemebiotech A/S Production of recombinant human lysosomal alpha-mannosidase
JP4742191B2 (ja) * 2001-06-14 2011-08-10 独立行政法人産業技術総合研究所 糖蛋白質およびその製造方法
US7507573B2 (en) * 2003-11-14 2009-03-24 Vib, Vzw Modification of protein glycosylation in methylotrophic yeast
EP1713904B1 (en) * 2004-01-30 2016-06-29 Shire Pharmaceuticals Ireland Limited Production and purification of recombinant arylsulfatase a
CA2556245A1 (en) * 2004-02-06 2005-08-25 Biomarin Pharmaceutical Inc. Manufacture of highly phosphorylated lysosomal enzymes and uses thereof
EP1740204B1 (en) 2004-04-01 2018-03-14 Chiesi Farmaceutici S.p.A. Medicinal use of alpha-mannosidase
PL2628746T3 (pl) * 2006-04-04 2019-07-31 Chiesi Farmaceutici S.P.A. Sposób zatężania polipeptydu
CN101410408A (zh) * 2006-04-04 2009-04-15 希尔制药爱尔兰有限责任公司 用于浓缩多肽的方法
US8399620B2 (en) * 2007-07-11 2013-03-19 Novo Nordisk A/S Purification of factor VIII using a mixed-mode or multimodal resin

Also Published As

Publication number Publication date
PL3281636T3 (pl) 2021-03-08
HUE037943T2 (hu) 2018-09-28
ES2652330T3 (es) 2018-02-01
CY2021002I1 (el) 2021-05-05
EP3281636A1 (en) 2018-02-14
HUS1800037I1 (hu) 2018-09-28
EA201270715A1 (ru) 2013-01-30
BR112012020934A2 (pt) 2017-02-21
US20120308549A1 (en) 2012-12-06
FR18C1038I1 (zh) 2018-11-02
EP3281636B1 (en) 2020-08-05
US20150306186A1 (en) 2015-10-29
DK3281636T3 (da) 2020-09-21
PT2538968T (pt) 2018-01-23
HRP20171736T1 (hr) 2018-01-26
NO2018032I1 (no) 2018-09-14
CY1123438T1 (el) 2021-05-05
US20180036387A1 (en) 2018-02-08
EP2538968A1 (en) 2013-01-02
RS60983B1 (sr) 2020-11-30
US10159718B2 (en) 2018-12-25
HK1179869A1 (zh) 2013-10-11
SI2538968T1 (en) 2018-04-30
CN102834111A (zh) 2012-12-19
BR112012020934A8 (pt) 2018-02-06
KR101856260B1 (ko) 2018-05-09
AU2011220163B2 (en) 2015-05-28
LTPA2018512I1 (lt) 2018-10-10
CA2790786C (en) 2019-09-24
NZ601790A (en) 2014-03-28
CN102834111B (zh) 2014-11-12
EP2538968B1 (en) 2017-11-01
NL300948I2 (nl) 2019-02-27
SI3281636T1 (sl) 2020-11-30
DK2538968T3 (en) 2017-12-11
LT2538968T (lt) 2018-01-10
LTC2538968I2 (lt) 2019-11-11
US8974780B2 (en) 2015-03-10
WO2011103877A1 (en) 2011-09-01
KR20120128647A (ko) 2012-11-27
JP2013520184A (ja) 2013-06-06
AU2011220163A1 (en) 2012-08-30
CA2790786A1 (en) 2011-09-01
JP6021647B2 (ja) 2016-11-09
NO2538968T3 (zh) 2018-03-31
PL2538968T3 (pl) 2018-04-30
BR112012020934B1 (pt) 2021-07-13
EA022220B1 (ru) 2015-11-30

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