FR1519964A - Bis-benzimidazoles porteurs de substituants basiques et leur préparation - Google Patents

Bis-benzimidazoles porteurs de substituants basiques et leur préparation

Info

Publication number
FR1519964A
FR1519964A FR101212A FR101212A FR1519964A FR 1519964 A FR1519964 A FR 1519964A FR 101212 A FR101212 A FR 101212A FR 101212 A FR101212 A FR 101212A FR 1519964 A FR1519964 A FR 1519964A
Authority
FR
France
Prior art keywords
bis
preparation
basic substituents
carrying basic
benzimidazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR101212A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Farbwerke Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG, Farbwerke Hoechst AG filed Critical Hoechst AG
Priority to FR112465A priority Critical patent/FR6681M/fr
Application granted granted Critical
Publication of FR1519964A publication Critical patent/FR1519964A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR101212A 1966-04-01 1967-04-03 Bis-benzimidazoles porteurs de substituants basiques et leur préparation Expired FR1519964A (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR112465A FR6681M (fr) 1966-04-01 1967-06-29

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF0048833 1966-04-01

Publications (1)

Publication Number Publication Date
FR1519964A true FR1519964A (fr) 1968-04-05

Family

ID=7102516

Family Applications (2)

Application Number Title Priority Date Filing Date
FR101212A Expired FR1519964A (fr) 1966-04-01 1967-04-03 Bis-benzimidazoles porteurs de substituants basiques et leur préparation
FR112465A Expired FR6681M (fr) 1966-04-01 1967-06-29

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR112465A Expired FR6681M (fr) 1966-04-01 1967-06-29

Country Status (9)

Country Link
US (1) US3538097A (fr)
BE (1) BE696499A (fr)
CH (2) CH533124A (fr)
DE (1) DE1670684A1 (fr)
FR (2) FR1519964A (fr)
GB (1) GB1186723A (fr)
MY (1) MY7100120A (fr)
NL (1) NL6704539A (fr)
OA (1) OA02583A (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240026A1 (fr) * 1986-04-04 1987-10-07 Roche Diagnostics GmbH Benzoglyoxalines substituées hétérocycliquement, procédé pour leur préparation et médicaments contenant ces composés
WO1996006831A1 (fr) * 1994-08-26 1996-03-07 Auckland Division Cancer Society Of New Zealand Inc. Nouveaux agents d'alkilation cibles sur l'adn
WO1997004776A1 (fr) * 1995-07-28 1997-02-13 The Inner And Eastern Health Care Network Radioprotecteurs
AU695936B2 (en) * 1994-08-26 1998-08-27 Auckland Division Cancer Society Of New Zealand Inc Novel dna-targeted alkylating agents
US10118920B2 (en) 2015-04-20 2018-11-06 Cellcentric Ltd Isoxazolyl substituted benzimidazoles
US10428065B2 (en) 2015-04-20 2019-10-01 Cellcentric Ltd Isoxazolyl substituted imidazopyridines

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091101A (en) * 1977-06-15 1978-05-23 Merck & Co., Inc. 6-(1-Piperazinyl)quinoxaline
US5807874A (en) * 1995-05-17 1998-09-15 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
US5767142A (en) * 1996-03-20 1998-06-16 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
PL332416A1 (en) * 1996-09-23 1999-09-13 Rutgers Substituted heterocyclic compounds as anticarcinogenic agents
US6140328A (en) 1997-12-12 2000-10-31 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
PL341539A1 (en) * 1997-12-31 2001-04-23 Rutgers Heterocyclic toxins of topoisomerases
IL137351A0 (en) 1998-02-12 2001-07-24 Univ Rutgers Heterocyclic topoisomerase poisons
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
EP1453812B1 (fr) 2001-11-14 2008-08-20 Rutgers, The State University Agents cytotoxiques
DE60225943T2 (de) * 2001-11-14 2009-01-29 Rutgers, The State University Topoisomerase-giftmittel
MXPA04004607A (es) * 2001-11-14 2004-09-10 Univ Rutgers Agentes de venenos de topoisomerasa solubilizados.
SI1465625T1 (sl) * 2001-11-14 2010-06-30 Univ Rutgers Solubilizirani topoizomerazni strupi
US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
US6992088B2 (en) * 2002-08-09 2006-01-31 Rutgers, The State University Of New Jersey Nitro and amino substituted heterocycles as topoisomerase I targeting agents
WO2004014918A1 (fr) 2002-08-09 2004-02-19 Rutgers, The State University Agents de la topoisomerase substitues par nitro et amino
US6992089B2 (en) * 2002-08-09 2006-01-31 Rutgers, The University Of New Jersey Nitro and amino substituted topoisomerase agents
JP4774212B2 (ja) * 2002-11-12 2011-09-14 ラトガーズ、ザ・ステイト・ユニバーシテイ・オブ・ニユー・ジヤージー トポイソメラーゼ−ターゲッティング剤
CN101083993A (zh) * 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
CN101084207A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
US8541457B2 (en) * 2005-06-03 2013-09-24 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors
CA2673417C (fr) * 2006-12-21 2015-09-15 Roger Francis Martin Composes de benzimidazole radioprotecteurs et procedes connexes
GB0821913D0 (en) 2008-12-02 2009-01-07 Price & Co Antibacterial compounds
JP5773888B2 (ja) 2009-03-06 2015-09-02 ラットガーズ，ザ・ステート・ユニバーシティ・オブ・ニュージャージー 癌治療に用いられるメチレンジオキシベンゾ［ｉ］フェナントリジン誘導体
WO2010127363A1 (fr) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Inhibiteurs de topoisomérase
JP5712524B2 (ja) * 2009-10-28 2015-05-07 Jsr株式会社 液晶配向剤および液晶表示素子
EP2575968B1 (fr) * 2010-06-01 2016-03-09 Summit Therapeutics plc Composés pour le traitement d'une maladie associée à clostridium difficile
AU2012267556B9 (en) * 2011-06-09 2017-05-11 Rhizen Pharmaceuticals Sa Novel compounds as modulators of GPR-119
US11434227B2 (en) * 2016-01-23 2022-09-06 Vibha TANDON Broad spectrum antibacterial activity of novel bisbenzimidazoles targeting topoisomerase IA and the synergistic composition of bisbenzimidazole with efflux pump inhibitors against pathogenic bacteria
EP3442979A4 (fr) 2016-04-04 2019-12-18 Rutgers, the State University of New Jersey Poisons de topoisomérase

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3103403A (en) * 1963-09-10 Dyeing of polyester fibers with com-
US2980690A (en) * 1957-08-30 1961-04-18 Ciba Pharm Prod Inc New basically substituted benzylbenzimidazoles
US3072661A (en) * 1960-08-24 1963-01-08 Interchem Corp New process for improved bis-imidazole vat dyestuff pigments
US3133056A (en) * 1961-05-15 1964-05-12 May & Baker Ltd N-phenylpiperazine derivatives of tetrahydrobenzodiazepines
BE631368A (fr) * 1962-04-21
NL135043C (fr) * 1963-10-11
GB1122988A (en) * 1964-10-22 1968-08-07 Fisons Pest Control Ltd Benzimidazole derivatives
US3336191A (en) * 1966-03-11 1967-08-15 Smith Kline French Lab Anthelmintic 2-amidobenzimidazoles
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240026A1 (fr) * 1986-04-04 1987-10-07 Roche Diagnostics GmbH Benzoglyoxalines substituées hétérocycliquement, procédé pour leur préparation et médicaments contenant ces composés
WO1996006831A1 (fr) * 1994-08-26 1996-03-07 Auckland Division Cancer Society Of New Zealand Inc. Nouveaux agents d'alkilation cibles sur l'adn
AU695936B2 (en) * 1994-08-26 1998-08-27 Auckland Division Cancer Society Of New Zealand Inc Novel dna-targeted alkylating agents
WO1997004776A1 (fr) * 1995-07-28 1997-02-13 The Inner And Eastern Health Care Network Radioprotecteurs
US6194414B1 (en) 1995-07-28 2001-02-27 The Inner And Eastern Health Care Network Radioprotectors
US6548505B1 (en) 1995-07-28 2003-04-15 Peter Maccallum Cancer Institute Radioprotectors
US10118920B2 (en) 2015-04-20 2018-11-06 Cellcentric Ltd Isoxazolyl substituted benzimidazoles
US10428065B2 (en) 2015-04-20 2019-10-01 Cellcentric Ltd Isoxazolyl substituted imidazopyridines

Also Published As

Publication number Publication date
CH525902A (de) 1972-07-31
US3538097A (en) 1970-11-03
DE1670684A1 (de) 1970-12-03
BE696499A (fr) 1967-10-03
FR6681M (fr) 1969-02-03
GB1186723A (en) 1970-04-02
NL6704539A (fr) 1967-10-02
MY7100120A (en) 1971-12-31
OA02583A (fr) 1970-05-05
CH533124A (de) 1973-01-31

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