FR1519964A - Bis-benzimidazoles porteurs de substituants basiques et leur préparation - Google Patents
Bis-benzimidazoles porteurs de substituants basiques et leur préparationInfo
- Publication number
- FR1519964A FR1519964A FR101212A FR101212A FR1519964A FR 1519964 A FR1519964 A FR 1519964A FR 101212 A FR101212 A FR 101212A FR 101212 A FR101212 A FR 101212A FR 1519964 A FR1519964 A FR 1519964A
- Authority
- FR
- France
- Prior art keywords
- bis
- preparation
- basic substituents
- carrying basic
- benzimidazoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000001424 substituent group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR112465A FR6681M (fr) | 1966-04-01 | 1967-06-29 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEF0048833 | 1966-04-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
FR1519964A true FR1519964A (fr) | 1968-04-05 |
Family
ID=7102516
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR101212A Expired FR1519964A (fr) | 1966-04-01 | 1967-04-03 | Bis-benzimidazoles porteurs de substituants basiques et leur préparation |
FR112465A Expired FR6681M (fr) | 1966-04-01 | 1967-06-29 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR112465A Expired FR6681M (fr) | 1966-04-01 | 1967-06-29 |
Country Status (9)
Country | Link |
---|---|
US (1) | US3538097A (fr) |
BE (1) | BE696499A (fr) |
CH (2) | CH533124A (fr) |
DE (1) | DE1670684A1 (fr) |
FR (2) | FR1519964A (fr) |
GB (1) | GB1186723A (fr) |
MY (1) | MY7100120A (fr) |
NL (1) | NL6704539A (fr) |
OA (1) | OA02583A (fr) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0240026A1 (fr) * | 1986-04-04 | 1987-10-07 | Roche Diagnostics GmbH | Benzoglyoxalines substituées hétérocycliquement, procédé pour leur préparation et médicaments contenant ces composés |
WO1996006831A1 (fr) * | 1994-08-26 | 1996-03-07 | Auckland Division Cancer Society Of New Zealand Inc. | Nouveaux agents d'alkilation cibles sur l'adn |
WO1997004776A1 (fr) * | 1995-07-28 | 1997-02-13 | The Inner And Eastern Health Care Network | Radioprotecteurs |
AU695936B2 (en) * | 1994-08-26 | 1998-08-27 | Auckland Division Cancer Society Of New Zealand Inc | Novel dna-targeted alkylating agents |
US10118920B2 (en) | 2015-04-20 | 2018-11-06 | Cellcentric Ltd | Isoxazolyl substituted benzimidazoles |
US10428065B2 (en) | 2015-04-20 | 2019-10-01 | Cellcentric Ltd | Isoxazolyl substituted imidazopyridines |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4091101A (en) * | 1977-06-15 | 1978-05-23 | Merck & Co., Inc. | 6-(1-Piperazinyl)quinoxaline |
US5807874A (en) * | 1995-05-17 | 1998-09-15 | Rutgers, The State University Of New Jersey | Trisbenzimidazoles useful as topoisomerase I inhibitors |
US5767142A (en) * | 1996-03-20 | 1998-06-16 | Rutgers, The State University Of New Jersey | Trisbenzimidazoles useful as topoisomerase I inhibitors |
PL332416A1 (en) * | 1996-09-23 | 1999-09-13 | Rutgers | Substituted heterocyclic compounds as anticarcinogenic agents |
US6140328A (en) | 1997-12-12 | 2000-10-31 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
PL341539A1 (en) * | 1997-12-31 | 2001-04-23 | Rutgers | Heterocyclic toxins of topoisomerases |
IL137351A0 (en) | 1998-02-12 | 2001-07-24 | Univ Rutgers | Heterocyclic topoisomerase poisons |
US6740650B2 (en) | 1999-10-29 | 2004-05-25 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
EP1453812B1 (fr) | 2001-11-14 | 2008-08-20 | Rutgers, The State University | Agents cytotoxiques |
DE60225943T2 (de) * | 2001-11-14 | 2009-01-29 | Rutgers, The State University | Topoisomerase-giftmittel |
MXPA04004607A (es) * | 2001-11-14 | 2004-09-10 | Univ Rutgers | Agentes de venenos de topoisomerasa solubilizados. |
SI1465625T1 (sl) * | 2001-11-14 | 2010-06-30 | Univ Rutgers | Solubilizirani topoizomerazni strupi |
US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
US6992088B2 (en) * | 2002-08-09 | 2006-01-31 | Rutgers, The State University Of New Jersey | Nitro and amino substituted heterocycles as topoisomerase I targeting agents |
WO2004014918A1 (fr) | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Agents de la topoisomerase substitues par nitro et amino |
US6992089B2 (en) * | 2002-08-09 | 2006-01-31 | Rutgers, The University Of New Jersey | Nitro and amino substituted topoisomerase agents |
JP4774212B2 (ja) * | 2002-11-12 | 2011-09-14 | ラトガーズ、ザ・ステイト・ユニバーシテイ・オブ・ニユー・ジヤージー | トポイソメラーゼ−ターゲッティング剤 |
CN101083993A (zh) * | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途 |
CN101084207A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途 |
US8541457B2 (en) * | 2005-06-03 | 2013-09-24 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors |
CA2673417C (fr) * | 2006-12-21 | 2015-09-15 | Roger Francis Martin | Composes de benzimidazole radioprotecteurs et procedes connexes |
GB0821913D0 (en) | 2008-12-02 | 2009-01-07 | Price & Co | Antibacterial compounds |
JP5773888B2 (ja) | 2009-03-06 | 2015-09-02 | ラットガーズ,ザ・ステート・ユニバーシティ・オブ・ニュージャージー | 癌治療に用いられるメチレンジオキシベンゾ[i]フェナントリジン誘導体 |
WO2010127363A1 (fr) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Inhibiteurs de topoisomérase |
JP5712524B2 (ja) * | 2009-10-28 | 2015-05-07 | Jsr株式会社 | 液晶配向剤および液晶表示素子 |
EP2575968B1 (fr) * | 2010-06-01 | 2016-03-09 | Summit Therapeutics plc | Composés pour le traitement d'une maladie associée à clostridium difficile |
AU2012267556B9 (en) * | 2011-06-09 | 2017-05-11 | Rhizen Pharmaceuticals Sa | Novel compounds as modulators of GPR-119 |
US11434227B2 (en) * | 2016-01-23 | 2022-09-06 | Vibha TANDON | Broad spectrum antibacterial activity of novel bisbenzimidazoles targeting topoisomerase IA and the synergistic composition of bisbenzimidazole with efflux pump inhibitors against pathogenic bacteria |
EP3442979A4 (fr) | 2016-04-04 | 2019-12-18 | Rutgers, the State University of New Jersey | Poisons de topoisomérase |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3103403A (en) * | 1963-09-10 | Dyeing of polyester fibers with com- | ||
US2980690A (en) * | 1957-08-30 | 1961-04-18 | Ciba Pharm Prod Inc | New basically substituted benzylbenzimidazoles |
US3072661A (en) * | 1960-08-24 | 1963-01-08 | Interchem Corp | New process for improved bis-imidazole vat dyestuff pigments |
US3133056A (en) * | 1961-05-15 | 1964-05-12 | May & Baker Ltd | N-phenylpiperazine derivatives of tetrahydrobenzodiazepines |
BE631368A (fr) * | 1962-04-21 | |||
NL135043C (fr) * | 1963-10-11 | |||
GB1122988A (en) * | 1964-10-22 | 1968-08-07 | Fisons Pest Control Ltd | Benzimidazole derivatives |
US3336191A (en) * | 1966-03-11 | 1967-08-15 | Smith Kline French Lab | Anthelmintic 2-amidobenzimidazoles |
US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
-
1966
- 1966-04-01 DE DE19661670684 patent/DE1670684A1/de active Pending
-
1967
- 1967-03-23 US US625329A patent/US3538097A/en not_active Expired - Lifetime
- 1967-03-28 CH CH594172A patent/CH533124A/de not_active IP Right Cessation
- 1967-03-28 CH CH429167A patent/CH525902A/de not_active IP Right Cessation
- 1967-03-30 GB GB04681/67A patent/GB1186723A/en not_active Expired
- 1967-03-30 NL NL6704539A patent/NL6704539A/xx unknown
- 1967-04-01 OA OA52892A patent/OA02583A/fr unknown
- 1967-04-03 BE BE696499D patent/BE696499A/xx unknown
- 1967-04-03 FR FR101212A patent/FR1519964A/fr not_active Expired
- 1967-06-29 FR FR112465A patent/FR6681M/fr not_active Expired
-
1971
- 1971-12-31 MY MY1971120A patent/MY7100120A/xx unknown
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0240026A1 (fr) * | 1986-04-04 | 1987-10-07 | Roche Diagnostics GmbH | Benzoglyoxalines substituées hétérocycliquement, procédé pour leur préparation et médicaments contenant ces composés |
WO1996006831A1 (fr) * | 1994-08-26 | 1996-03-07 | Auckland Division Cancer Society Of New Zealand Inc. | Nouveaux agents d'alkilation cibles sur l'adn |
AU695936B2 (en) * | 1994-08-26 | 1998-08-27 | Auckland Division Cancer Society Of New Zealand Inc | Novel dna-targeted alkylating agents |
WO1997004776A1 (fr) * | 1995-07-28 | 1997-02-13 | The Inner And Eastern Health Care Network | Radioprotecteurs |
US6194414B1 (en) | 1995-07-28 | 2001-02-27 | The Inner And Eastern Health Care Network | Radioprotectors |
US6548505B1 (en) | 1995-07-28 | 2003-04-15 | Peter Maccallum Cancer Institute | Radioprotectors |
US10118920B2 (en) | 2015-04-20 | 2018-11-06 | Cellcentric Ltd | Isoxazolyl substituted benzimidazoles |
US10428065B2 (en) | 2015-04-20 | 2019-10-01 | Cellcentric Ltd | Isoxazolyl substituted imidazopyridines |
Also Published As
Publication number | Publication date |
---|---|
CH525902A (de) | 1972-07-31 |
US3538097A (en) | 1970-11-03 |
DE1670684A1 (de) | 1970-12-03 |
BE696499A (fr) | 1967-10-03 |
FR6681M (fr) | 1969-02-03 |
GB1186723A (en) | 1970-04-02 |
NL6704539A (fr) | 1967-10-02 |
MY7100120A (en) | 1971-12-31 |
OA02583A (fr) | 1970-05-05 |
CH533124A (de) | 1973-01-31 |
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