CH525902A - Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten - Google Patents

Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten

Info

Publication number
CH525902A
CH525902A CH429167A CH429167A CH525902A CH 525902 A CH525902 A CH 525902A CH 429167 A CH429167 A CH 429167A CH 429167 A CH429167 A CH 429167A CH 525902 A CH525902 A CH 525902A
Authority
CH
Switzerland
Prior art keywords
preparation
benzimidazole derivatives
substituted bis
basic substituted
basic
Prior art date
Application number
CH429167A
Other languages
English (en)
Inventor
Loewe Heinz
Urbanietz Josef
Laemmler Georg
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Priority to CH594172A priority Critical patent/CH533124A/de
Publication of CH525902A publication Critical patent/CH525902A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CH429167A 1966-04-01 1967-03-28 Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten CH525902A (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CH594172A CH533124A (de) 1966-04-01 1967-03-28 Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF0048833 1966-04-01

Publications (1)

Publication Number Publication Date
CH525902A true CH525902A (de) 1972-07-31

Family

ID=7102516

Family Applications (2)

Application Number Title Priority Date Filing Date
CH594172A CH533124A (de) 1966-04-01 1967-03-28 Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten
CH429167A CH525902A (de) 1966-04-01 1967-03-28 Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CH594172A CH533124A (de) 1966-04-01 1967-03-28 Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten

Country Status (9)

Country Link
US (1) US3538097A (de)
BE (1) BE696499A (de)
CH (2) CH533124A (de)
DE (1) DE1670684A1 (de)
FR (2) FR1519964A (de)
GB (1) GB1186723A (de)
MY (1) MY7100120A (de)
NL (1) NL6704539A (de)
OA (1) OA02583A (de)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091101A (en) * 1977-06-15 1978-05-23 Merck & Co., Inc. 6-(1-Piperazinyl)quinoxaline
DE3611343A1 (de) * 1986-04-04 1987-10-08 Boehringer Mannheim Gmbh Heterocyclisch substituierte benzimidazole, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte
AU695936B2 (en) * 1994-08-26 1998-08-27 Auckland Division Cancer Society Of New Zealand Inc Novel dna-targeted alkylating agents
WO1996006831A1 (en) * 1994-08-26 1996-03-07 Auckland Division Cancer Society Of New Zealand Inc. Novel dna-targeted alkylating agents
US5767142A (en) * 1996-03-20 1998-06-16 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
US5807874A (en) * 1995-05-17 1998-09-15 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
AUPN449295A0 (en) 1995-07-28 1995-08-24 Inner And Eastern Health Care Network, The Radioprotectors
PL332416A1 (en) * 1996-09-23 1999-09-13 Rutgers Substituted heterocyclic compounds as anticarcinogenic agents
US6140328A (en) * 1997-12-12 2000-10-31 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
EP1044199B1 (de) * 1997-12-31 2008-07-23 Rutgers, The State University Of New Jersey Heterocyclische topoisomerase toxine
IL137351A0 (en) 1998-02-12 2001-07-24 Univ Rutgers Heterocyclic topoisomerase poisons
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
PT1465625E (pt) * 2001-11-14 2010-03-09 Univ Rutgers Venenos de topoisomerase solubilizados
DE60225943T2 (de) * 2001-11-14 2009-01-29 Rutgers, The State University Topoisomerase-giftmittel
AU2002352708A1 (en) * 2001-11-14 2003-05-26 Edmond J. Lavoie Cytotoxic agents
EP1453507B1 (de) * 2001-11-14 2009-03-04 Rutgers, The State University Solubilisierte topoisomerase-gift-mittel
US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
AU2003268075A1 (en) * 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
US6992088B2 (en) * 2002-08-09 2006-01-31 Rutgers, The State University Of New Jersey Nitro and amino substituted heterocycles as topoisomerase I targeting agents
WO2004014918A1 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted topoisomerase agents
JP4774212B2 (ja) * 2002-11-12 2011-09-14 ラトガーズ、ザ・ステイト・ユニバーシテイ・オブ・ニユー・ジヤージー トポイソメラーゼ−ターゲッティング剤
CA2580856A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
WO2006101521A2 (en) * 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AU2006343359A1 (en) * 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
CA2673417C (en) * 2006-12-21 2015-09-15 Roger Francis Martin Radioprotective benzimidazole compounds and related methods
GB0821913D0 (en) 2008-12-02 2009-01-07 Price & Co Antibacterial compounds
PT2403856E (pt) 2009-03-06 2013-03-25 Univ Rutgers Derivados de metilendioxibenzo[i]fenantridina utilizados para tratar o cancro
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
JP5712524B2 (ja) * 2009-10-28 2015-05-07 Jsr株式会社 液晶配向剤および液晶表示素子
AU2011260097B2 (en) * 2010-06-01 2015-01-22 Summit (Oxford) Limited Compounds for the treatment of clostridium difficile associated disease
KR101913619B1 (ko) * 2011-06-09 2018-12-28 리젠 파마슈티컬스 소시에떼 아노님 Gpr-119의 조절제로서의 신규한 화합물
GB201506660D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
GB201506658D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
US11434227B2 (en) * 2016-01-23 2022-09-06 Vibha TANDON Broad spectrum antibacterial activity of novel bisbenzimidazoles targeting topoisomerase IA and the synergistic composition of bisbenzimidazole with efflux pump inhibitors against pathogenic bacteria
CN109219610A (zh) 2016-04-04 2019-01-15 新泽西州立拉特格斯大学 拓扑异构酶毒物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3103403A (en) * 1963-09-10 Dyeing of polyester fibers with com-
US2980690A (en) * 1957-08-30 1961-04-18 Ciba Pharm Prod Inc New basically substituted benzylbenzimidazoles
US3072661A (en) * 1960-08-24 1963-01-08 Interchem Corp New process for improved bis-imidazole vat dyestuff pigments
US3133056A (en) * 1961-05-15 1964-05-12 May & Baker Ltd N-phenylpiperazine derivatives of tetrahydrobenzodiazepines
NL291735A (de) * 1962-04-21
NL135043C (de) * 1963-10-11
GB1122988A (en) * 1964-10-22 1968-08-07 Fisons Pest Control Ltd Benzimidazole derivatives
US3336191A (en) * 1966-03-11 1967-08-15 Smith Kline French Lab Anthelmintic 2-amidobenzimidazoles
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines

Also Published As

Publication number Publication date
FR6681M (de) 1969-02-03
CH533124A (de) 1973-01-31
BE696499A (de) 1967-10-03
NL6704539A (de) 1967-10-02
MY7100120A (en) 1971-12-31
US3538097A (en) 1970-11-03
FR1519964A (fr) 1968-04-05
GB1186723A (en) 1970-04-02
DE1670684A1 (de) 1970-12-03
OA02583A (fr) 1970-05-05

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Legal Events

Date Code Title Description
PL Patent ceased