FI981818A - Osteogeniskt medel och förfarande för framställning av medlet - Google Patents
Osteogeniskt medel och förfarande för framställning av medlet Download PDFInfo
- Publication number
- FI981818A FI981818A FI981818A FI981818A FI981818A FI 981818 A FI981818 A FI 981818A FI 981818 A FI981818 A FI 981818A FI 981818 A FI981818 A FI 981818A FI 981818 A FI981818 A FI 981818A
- Authority
- FI
- Finland
- Prior art keywords
- protein
- osteogenic
- collagen
- properties
- making
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/84—Bones; tendons; teeth; cartilage
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI981818A FI120253B (sv) | 1996-02-29 | 1998-08-25 | Osteogeniskt medel och förfarande för framställning av medlet |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/FI1996/000118 WO1997031661A1 (en) | 1996-02-29 | 1996-02-29 | An osteogenic device and a method for preparing the device |
FI9600118 | 1996-02-29 | ||
FI981818 | 1998-08-25 | ||
FI981818A FI120253B (sv) | 1996-02-29 | 1998-08-25 | Osteogeniskt medel och förfarande för framställning av medlet |
Publications (3)
Publication Number | Publication Date |
---|---|
FI981818A0 FI981818A0 (sv) | 1998-08-25 |
FI981818A true FI981818A (sv) | 1998-10-12 |
FI120253B FI120253B (sv) | 2009-08-31 |
Family
ID=8556642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI981818A FI120253B (sv) | 1996-02-29 | 1998-08-25 | Osteogeniskt medel och förfarande för framställning av medlet |
Country Status (8)
Country | Link |
---|---|
US (1) | US7186811B2 (sv) |
EP (1) | EP0883410B1 (sv) |
AT (1) | ATE273723T1 (sv) |
AU (1) | AU4721696A (sv) |
DE (1) | DE69633197T2 (sv) |
ES (1) | ES2225870T3 (sv) |
FI (1) | FI120253B (sv) |
WO (1) | WO1997031661A1 (sv) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL133739A (en) * | 1997-07-07 | 2005-03-20 | Australian Inst Marine Science | Shaped products or structures for medical or related purposes |
AU731916B2 (en) * | 1997-07-07 | 2001-04-05 | Australian Institute Of Marine Science | Shaped products or structures for medical or related purposes |
CN1068198C (zh) * | 1998-12-21 | 2001-07-11 | 冶金工业部钢铁研究总院 | 骨形态发生蛋白与胶原颗粒复合剂型的制造方法 |
ATE253385T1 (de) | 1999-02-04 | 2003-11-15 | Sdgi Holdings Inc | Hochmineralisierte osteogene schwammzusammensetzungen und ihre verwendung |
US7687462B2 (en) | 1999-10-05 | 2010-03-30 | The Regents Of The University Of California | Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition |
DE19962248A1 (de) * | 1999-12-22 | 2001-06-28 | Tutogen Medical Gmbh | Verfahren zur Herstellung eines mit Knochenwachstumsfaktoren angereicherten Knochenmaterials |
FI117963B (sv) | 2001-04-26 | 2007-05-15 | Eija Marjut Pirhonen | Material som ersätter ben |
WO2003043673A1 (en) * | 2001-11-19 | 2003-05-30 | Scil Technology Gmbh | Device having osteoinductive and osteoconductive properties |
CN1302822C (zh) * | 2002-11-28 | 2007-03-07 | 上海瑞邦生物材料有限公司 | 自固化磷酸钙原位成骨活性骨水泥及其制备方法和应用 |
US6974862B2 (en) | 2003-06-20 | 2005-12-13 | Kensey Nash Corporation | High density fibrous polymers suitable for implant |
US8415302B2 (en) | 2004-01-28 | 2013-04-09 | The Regents Of The University Of California | Surgical applications for BMP binding protein |
WO2005072403A2 (en) | 2004-01-28 | 2005-08-11 | The Regents Of The University Of California | Bone morphogenic protein binding peptide |
US8193312B2 (en) | 2004-01-28 | 2012-06-05 | The Regents Of The University Of California | Bone morphogenic protein binding peptide |
US7189409B2 (en) | 2004-03-09 | 2007-03-13 | Inion Ltd. | Bone grafting material, method and implant |
EP1604694A1 (en) * | 2004-06-09 | 2005-12-14 | Scil Technology GmbH | Composite device having osteoinductive and osteoconductive properties |
US7722895B1 (en) | 2004-09-20 | 2010-05-25 | Warsaw Orthopedic, Inc. | Osteogenic implants with combined implant materials, and materials and methods for same |
US8753660B2 (en) | 2004-11-29 | 2014-06-17 | The Regents Of The University Of California | Activating extraction of demineralized bone matrix |
US8506646B2 (en) | 2005-04-29 | 2013-08-13 | Warsaw Orthopedic, Inc. | Multi-purpose medical implant devices |
US7531190B2 (en) | 2005-05-25 | 2009-05-12 | Biomet Manufacturing Corp. | Porous ceramic structure containing biologics |
US7833270B2 (en) * | 2006-05-05 | 2010-11-16 | Warsaw Orthopedic, Inc | Implant depots to deliver growth factors to treat osteoporotic bone |
US8101198B2 (en) | 2006-07-26 | 2012-01-24 | The Regents Of The University Of California | Osteogenic enhancer composition |
US20080233203A1 (en) | 2007-03-21 | 2008-09-25 | Jennifer Woodell-May | Porous orthapedic materials coated with demineralized bone matrix |
AU2008255016B2 (en) * | 2007-05-15 | 2013-05-09 | Stryker Corporation | Concentrated protein preparations of bone morphogenetic proteins and methods of use thereof |
US8133553B2 (en) | 2007-06-18 | 2012-03-13 | Zimmer, Inc. | Process for forming a ceramic layer |
US8309521B2 (en) | 2007-06-19 | 2012-11-13 | Zimmer, Inc. | Spacer with a coating thereon for use with an implant device |
US8608049B2 (en) * | 2007-10-10 | 2013-12-17 | Zimmer, Inc. | Method for bonding a tantalum structure to a cobalt-alloy substrate |
US20090187256A1 (en) * | 2008-01-21 | 2009-07-23 | Zimmer, Inc. | Method for forming an integral porous region in a cast implant |
US20090198286A1 (en) * | 2008-02-05 | 2009-08-06 | Zimmer, Inc. | Bone fracture fixation system |
KR20120018202A (ko) | 2009-05-26 | 2012-02-29 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 파이브로모듈린 펩타이드 |
US9072709B2 (en) | 2009-06-23 | 2015-07-07 | The Regents Of The University Of California | Enhancement of bone morphogenic protein (BMP) retention with BMP binding peptide (BBP) |
US8994666B2 (en) * | 2009-12-23 | 2015-03-31 | Colin J. Karpfinger | Tactile touch-sensing interface system |
WO2011143226A1 (en) | 2010-05-11 | 2011-11-17 | Howmedica Osteonics Corp. | Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods |
US10702584B2 (en) | 2010-06-28 | 2020-07-07 | Bbs-Bioactive Bone Substitutes Oyj | Method for preparing a bone protein preparation and a bone protein preparation |
AU2011291537B2 (en) | 2010-08-19 | 2016-06-02 | The Regents Of The University Of California | Compositions comprising perivascular stem cells and Nell-1 protein |
US8551525B2 (en) | 2010-12-23 | 2013-10-08 | Biostructures, Llc | Bone graft materials and methods |
JP5996330B2 (ja) * | 2012-08-21 | 2016-09-21 | 株式会社シャネル化粧品技術開発研究所 | 複合粒子及びそれを含む化粧料組成物 |
US20180169041A1 (en) | 2014-03-20 | 2018-06-21 | Stayble Therapeutics Ab | Composition for use in the treatment of intervertebral disc-related pain |
US10238507B2 (en) | 2015-01-12 | 2019-03-26 | Surgentec, Llc | Bone graft delivery system and method for using same |
WO2017046030A1 (en) | 2015-09-14 | 2017-03-23 | Stayble Therapeutics Ab | A composition for use in the treatment of intervertebral disc-related pain |
CN105624058A (zh) * | 2015-12-04 | 2016-06-01 | 辽宁省海洋水产科学研究院 | 一株海洋柴油降解菌bhb-16及其固定化方法 |
US11116647B2 (en) | 2018-04-13 | 2021-09-14 | Surgentec, Llc | Bone graft delivery system and method for using same |
US10687828B2 (en) | 2018-04-13 | 2020-06-23 | Surgentec, Llc | Bone graft delivery system and method for using same |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4294753A (en) * | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
US4455256A (en) * | 1981-05-05 | 1984-06-19 | The Regents Of The University Of California | Bone morphogenetic protein |
US4761471A (en) * | 1980-08-04 | 1988-08-02 | The Regents Of The University Of California | Bone morphogenetic protein composition |
US4789732A (en) * | 1980-08-04 | 1988-12-06 | Regents Of The University Of California | Bone morphogenetic protein composition |
US4434094A (en) * | 1983-04-12 | 1984-02-28 | Collagen Corporation | Partially purified osteogenic factor and process for preparing same from demineralized bone |
US4804744A (en) * | 1984-01-04 | 1989-02-14 | International Genetic Engineering, Inc. | Osteogenic factors |
US4608199A (en) * | 1984-03-20 | 1986-08-26 | Arnold Caplan | Bone protein purification process |
US4843063A (en) * | 1984-07-16 | 1989-06-27 | Collagen Corporation | Polypeptide cartilage-inducing factors found in bone |
US4627982A (en) * | 1984-07-16 | 1986-12-09 | Collagen Corporation | Partially purified bone-inducing factor |
ATE128715T1 (de) * | 1984-07-16 | 1995-10-15 | Celtrix Pharma | Polypeptide induzierende faktoren in knochen und knorpel. |
US4563350A (en) * | 1984-10-24 | 1986-01-07 | Collagen Corporation | Inductive collagen based bone repair preparations |
US4886747A (en) * | 1985-03-22 | 1989-12-12 | Genentech, Inc. | Nucleic acid encoding TGF-β and its uses |
US4681763A (en) * | 1985-06-11 | 1987-07-21 | University Of Medicine And Dentistry Of New Jersey | Composition for stimulating bone growth |
JPH0662679B2 (ja) * | 1985-06-21 | 1994-08-17 | 新田ゼラチン株式会社 | 組織親和性コラ−ゲンとその製法 |
US4798885A (en) * | 1986-02-07 | 1989-01-17 | Genentech, Inc. | Compositions of hormonally active human and porcine inhibin containing an α chain and 62 chain |
US4737578A (en) * | 1986-02-10 | 1988-04-12 | The Salk Institute For Biological Studies | Human inhibin |
US5459047A (en) * | 1986-07-01 | 1995-10-17 | Genetics Institute, Inc. | BMP-6 proteins |
US5631142A (en) * | 1986-07-01 | 1997-05-20 | Genetics Institute, Inc. | Compositions comprising bone morphogenetic protein-2 (BMP-2) |
US5187076A (en) * | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
US5108753A (en) * | 1988-04-08 | 1992-04-28 | Creative Biomolecules | Osteogenic devices |
US4968590A (en) * | 1988-04-08 | 1990-11-06 | Stryker Corporation | Osteogenic proteins and polypeptides |
US5011691A (en) * | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
US5106626A (en) * | 1988-10-11 | 1992-04-21 | International Genetic Engineering, Inc. | Osteogenic factors |
US5071655A (en) * | 1990-01-12 | 1991-12-10 | Baylink David J | Pharmaceutical combination for treatment of bone-wasting diseases |
JP3356775B2 (ja) * | 1990-11-30 | 2002-12-16 | セルトリックス ファーマシューティカルズ, インコーポレイテッド | TGF―βとの共同的組合せによる骨修復のための骨形成タンパク質の使用 |
ATE238417T1 (de) * | 1991-11-04 | 2003-05-15 | Inst Genetics Llc | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
FR2706768B1 (sv) * | 1993-05-13 | 1995-12-01 | Inoteb |
-
1996
- 1996-02-29 EP EP96903037A patent/EP0883410B1/en not_active Expired - Lifetime
- 1996-02-29 AT AT96903037T patent/ATE273723T1/de not_active IP Right Cessation
- 1996-02-29 AU AU47216/96A patent/AU4721696A/en not_active Abandoned
- 1996-02-29 WO PCT/FI1996/000118 patent/WO1997031661A1/en active IP Right Grant
- 1996-02-29 DE DE69633197T patent/DE69633197T2/de not_active Expired - Lifetime
- 1996-02-29 ES ES96903037T patent/ES2225870T3/es not_active Expired - Lifetime
-
1998
- 1998-08-25 FI FI981818A patent/FI120253B/sv not_active IP Right Cessation
-
2004
- 2004-01-20 US US10/759,244 patent/US7186811B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1997031661A1 (en) | 1997-09-04 |
US7186811B2 (en) | 2007-03-06 |
FI981818A0 (sv) | 1998-08-25 |
FI120253B (sv) | 2009-08-31 |
AU4721696A (en) | 1997-09-16 |
ATE273723T1 (de) | 2004-09-15 |
US20050142164A1 (en) | 2005-06-30 |
ES2225870T3 (es) | 2005-03-16 |
DE69633197D1 (de) | 2004-09-23 |
EP0883410A1 (en) | 1998-12-16 |
EP0883410B1 (en) | 2004-08-18 |
DE69633197T2 (de) | 2005-08-18 |
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