FI117963B - Material som ersätter ben - Google Patents

Material som ersätter ben Download PDF

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Publication number
FI117963B
FI117963B FI20010873A FI20010873A FI117963B FI 117963 B FI117963 B FI 117963B FI 20010873 A FI20010873 A FI 20010873A FI 20010873 A FI20010873 A FI 20010873A FI 117963 B FI117963 B FI 117963B
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FI
Finland
Prior art keywords
support structure
fibers
porous support
agents
bioactive glass
Prior art date
Application number
FI20010873A
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English (en)
Finnish (fi)
Other versions
FI20010873A (sv
FI20010873A0 (sv
Inventor
Eija Marjut Pirhonen
Original Assignee
Eija Marjut Pirhonen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eija Marjut Pirhonen filed Critical Eija Marjut Pirhonen
Priority to FI20010873A priority Critical patent/FI117963B/sv
Publication of FI20010873A0 publication Critical patent/FI20010873A0/sv
Priority to US09/981,676 priority patent/US7241486B2/en
Priority to PCT/FI2002/000351 priority patent/WO2002087647A1/en
Publication of FI20010873A publication Critical patent/FI20010873A/sv
Application granted granted Critical
Publication of FI117963B publication Critical patent/FI117963B/sv

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2803—Bones for mandibular reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/3092—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having an open-celled or open-pored structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30968—Sintering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2002/4495—Joints for the spine, e.g. vertebrae, spinal discs having a fabric structure, e.g. made from wires or fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00329—Glasses, e.g. bioglass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249924—Noninterengaged fiber-containing paper-free web or sheet which is not of specified porosity
    • Y10T428/24994—Fiber embedded in or on the surface of a polymeric matrix
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249924—Noninterengaged fiber-containing paper-free web or sheet which is not of specified porosity
    • Y10T428/24994—Fiber embedded in or on the surface of a polymeric matrix
    • Y10T428/249942—Fibers are aligned substantially parallel
    • Y10T428/249946—Glass fiber

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Molecular Biology (AREA)
  • Ceramic Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Claims (20)

1. Porös stödstruktur (1) som är avsedd att implanteras i benvävnad för medicinsk användning, kännetecknad av att stödstrukturen är bildad 5 genom att sintra bioaktiva glasfibrer, vilka fibrers diameter är 0,075-0,175 mm och stödstrukturens porositet är 50-90 volym-%.
2. Porös stödstruktur (1) enligt patentkrav 1, kännetecknad av att stödstrukturen är bildad genom att sintra bioaktiva glasfibrer varefter stödstrukturen belagts med en biokompatibel polymer eller polymerer, kopolymerer 10 därav eller polymerblandningar därav.
3. Porös stödstruktur (1) enligt patentkrav 2, kännetecknad av att den biokompatibla polymeren/polymererna väljs fran en grupp bestäende av polyglykolid, polylaktid, poly-p-hydroxismörsyra, polydioxanon, polyvinylal-kohol, polyesteramin, kopolymerer därav och polymerblandningar därav.
4. Porös stödstruktur (1) enligt patentkrav 2 eller 3, känneteck nad av att beläggningens tjocklek är 1-200 μιτι, fördelaktigt 5-30 μιη.
5. Porös stödstruktur (1) enligt nägot av de föregaende patent-kraven, kännetecknad av att fibrernas längd är 2-30 mm, fördelaktigt 5-15 mm.
6. Porös stödstruktur (1) enligt nägot av de föregaende patentkra- ·· * • V ven, kännetecknad av att den porösa stödstrukturens tryckhällfasthet är 5-25 MPa, fördelaktigt över 20 MPa.
7. Porös stödstruktur (1) enligt nägot av de föregaende patentkra- • · .***. ven, kännetecknad av att stödstrukturen är fäst pä en biokompatibel po- 25 lymerfilm.
• · ..... 8. Porös stödstruktur (1) enligt patentkrav 7, kännetecknad av • · "* att den biokompatibla polymerfilmen (2) omfattar en polymer eller polymerer „ som väljs frän en grupp bestäende av polyglykolid, polylaktid, poly-p-hydroxi- • * smorsyra, polydioxanon, polyvinylalkohol, polyesteramin, kopolymerer därav 30 och polymerblandningar därav.
9. Förfarande för framställning av en porös stödstruktur (1) enligt • · .·**. patentkrav 1, kännetecknat av att stödstrukturen bildas genom att sintra bioaktiva glasfibrer. • · ·
10. Förfarande enligt patentkrav 9, kännetecknat av att bioakti-35 va glasfibrer sintras samman vid en temperatur av 300-1500 °C, fördelaktigt 600-700 °C, fördelaktigast 630-680 °C. 117963
11. Förfarande eniigt patentkrav 9 eller 10, kännetecknat avatt stödstrukturen framställs genom att sintra bioaktiva glasfibrer, varefter stöd-strukturen beläggs med en biokompatibel polymer eller polymerer, kopolyme- \ rer därav eller polymerblandningar därav. 5
12. Förfarande eniigt nagot av patentkraven 9-11, känneteck nat av att den bioaktiva glasfiberns sammansättning är 53-60 vikt-% Si02, 0-34 vikt-% Na20, 1-20 vikt-% K20, 0-5 vikt-% MgO, 5-25 vikt-% CaO, 0-4 vikt-% B203, 0,5-6 vikt-% P2O5 under förutsättning att Na20 + K20 = 16-35 vikt-%; K20 + MgO = 5-20 vikt-% och MgO + CaO = 10-25 vikt-%. 10
13. Förfarande eniigt nägot av patentkraven 9-12, känneteck nat av att det bioaktiva glasets sammansättning är 53 vikt-% Si02, 6 vikt-% Na20, 12 vikt-% K20, 5 vikt-% MgO, 20 vikt-% CaO, 0 vikt-% B203 och 4 vikt-% p2o5.
14. Förfarande eniigt nagot av patentkraven 9-13, känneteck-15 n at av att sintringstiden är 1-120 minuter, fördelaktigt 5-30 minuter.
15. Förfarande eniigt nagot av patentkraven 9-14, kännetecknat av att fibrerna sintras samman under tryckbelastning.
16. Förfarande eniigt nagot av patentkraven 9-15, kännetecknat av att fibrerna (8) sintras samman i en form (9). 20
17. Förfarande eniigt nägot av patentkraven 9-16, känneteck nat av att fibrerna sintras att bilda en matta (7) som fästs vid ett membran (6).
18. Användning av en porös stödstruktur (1) eniigt nagot av patent- : *·* kraven 1-8 som bärare för bioaktiva ämnen.
·*.:[.* 19. Användning av en porös stödstruktur (1) eniigt patentkrav 18, 25 kännetecknad av att det bioaktiva ämnet väljs frän en grupp som bestär • · t ·;··· av antiinflammatoriska ämnen, antibakteriska ämnen, antiparasitiska ämnen, .···. antifungala ämnen, antivirala ämnen, antineoplastiska ämnen, analgetiska ämnen, anestetika, vacciner, centrala nervsystemets ämnen, tillväxtfaktorer, ;.t hormoner, antihistaminer, osteoinduktiva ämnen, kardiovaskulära ämnen, an- *..!* 30 tiulserativa ämnen, bronkodilatorer, vasodilatorer, ämnen som reglerar naiivi- • *·;·* tet, ämnen som ökar fertilitet och polypeptider.
20. Användning av en porös stödstruktur (1) eniigt patentkrav 18 el-ler 19, kännetecknad av att det bioaktiva ämne är ett benmorfogent prote- • · · in. • · * • · · ··♦ * * · * · · • ·
FI20010873A 2001-04-26 2001-04-26 Material som ersätter ben FI117963B (sv)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FI20010873A FI117963B (sv) 2001-04-26 2001-04-26 Material som ersätter ben
US09/981,676 US7241486B2 (en) 2001-04-26 2001-10-16 Bone grafting materials
PCT/FI2002/000351 WO2002087647A1 (en) 2001-04-26 2002-04-25 Bone grafting materials

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20010873 2001-04-26
FI20010873A FI117963B (sv) 2001-04-26 2001-04-26 Material som ersätter ben

Publications (3)

Publication Number Publication Date
FI20010873A0 FI20010873A0 (sv) 2001-04-26
FI20010873A FI20010873A (sv) 2002-10-27
FI117963B true FI117963B (sv) 2007-05-15

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US7241486B2 (en) 2007-07-10
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FI20010873A0 (sv) 2001-04-26

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