FI981062A - Geeniteknisesti aikaansaaduilla streptomyces galilaeus-kannoilla tuotetut hybridiantrasykliinit - Google Patents

Geeniteknisesti aikaansaaduilla streptomyces galilaeus-kannoilla tuotetut hybridiantrasykliinit Download PDF

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Publication number
FI981062A
FI981062A FI981062A FI981062A FI981062A FI 981062 A FI981062 A FI 981062A FI 981062 A FI981062 A FI 981062A FI 981062 A FI981062 A FI 981062A FI 981062 A FI981062 A FI 981062A
Authority
FI
Finland
Prior art keywords
deoxyfucose
genetically engineered
galilaeus
engineered strains
strain
Prior art date
Application number
FI981062A
Other languages
English (en)
Swedish (sv)
Other versions
FI105554B (fi
FI981062A0 (fi
Inventor
Kristiina Ylihonko
Juha Hakala
Tero Kunnari
Original Assignee
Galilaeus Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galilaeus Oy filed Critical Galilaeus Oy
Publication of FI981062A0 publication Critical patent/FI981062A0/fi
Priority to FI981062A priority Critical patent/FI105554B/fi
Priority to PCT/FI1999/000385 priority patent/WO1999058544A1/en
Priority to EP99923618A priority patent/EP1000078B1/en
Priority to AT99923618T priority patent/ATE246198T1/de
Priority to US09/462,671 priority patent/US6399583B1/en
Priority to DK99923618T priority patent/DK1000078T3/da
Priority to JP2000548348A priority patent/JP2002514399A/ja
Priority to DE69909938T priority patent/DE69909938T2/de
Priority to ES99923618T priority patent/ES2205825T3/es
Publication of FI981062A publication Critical patent/FI981062A/fi
Application granted granted Critical
Publication of FI105554B publication Critical patent/FI105554B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
FI981062A 1998-05-13 1998-05-13 Geenimuunnelluista Streptomyces galilaeus-kannoista saatavat hybridiantrasykliinit FI105554B (fi)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FI981062A FI105554B (fi) 1998-05-13 1998-05-13 Geenimuunnelluista Streptomyces galilaeus-kannoista saatavat hybridiantrasykliinit
US09/462,671 US6399583B1 (en) 1998-05-13 1999-05-10 Hybrid anthracyclines from genetically engineered streptomyces galilaeus strains, process for production and uses thereof
EP99923618A EP1000078B1 (en) 1998-05-13 1999-05-10 Hybrid anthracyclines from genetically engineered streptomyces galilaeus strains
AT99923618T ATE246198T1 (de) 1998-05-13 1999-05-10 Hydrid-anthrazykline aus gentechnisch hergestellten streptomyces galileaus stämmen
PCT/FI1999/000385 WO1999058544A1 (en) 1998-05-13 1999-05-10 Hybrid anthracyclines from genetically engineered streptomyces galilaeus strains
DK99923618T DK1000078T3 (da) 1998-05-13 1999-05-10 Hybrid-anthracycliner fra genetisk fremstillede streptomyces Galilæus-stammer
JP2000548348A JP2002514399A (ja) 1998-05-13 1999-05-10 遺伝子工学処理したストレプトマイセス・ガリレウス株由来のハイブリッドアントラサイクリン
DE69909938T DE69909938T2 (de) 1998-05-13 1999-05-10 Hydrid-anthrazykline aus gentechnisch hergestellten streptomyces galileaus stämmen
ES99923618T ES2205825T3 (es) 1998-05-13 1999-05-10 Antraciclinas hibridas procedentes de cepas de streptomyces galilaeus obtenidas por ingenieria genetica.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI981062 1998-05-13
FI981062A FI105554B (fi) 1998-05-13 1998-05-13 Geenimuunnelluista Streptomyces galilaeus-kannoista saatavat hybridiantrasykliinit

Publications (3)

Publication Number Publication Date
FI981062A0 FI981062A0 (fi) 1998-05-13
FI981062A true FI981062A (fi) 1999-11-14
FI105554B FI105554B (fi) 2000-09-15

Family

ID=8551716

Family Applications (1)

Application Number Title Priority Date Filing Date
FI981062A FI105554B (fi) 1998-05-13 1998-05-13 Geenimuunnelluista Streptomyces galilaeus-kannoista saatavat hybridiantrasykliinit

Country Status (9)

Country Link
US (1) US6399583B1 (fi)
EP (1) EP1000078B1 (fi)
JP (1) JP2002514399A (fi)
AT (1) ATE246198T1 (fi)
DE (1) DE69909938T2 (fi)
DK (1) DK1000078T3 (fi)
ES (1) ES2205825T3 (fi)
FI (1) FI105554B (fi)
WO (1) WO1999058544A1 (fi)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1329493A (zh) * 1998-12-02 2002-01-02 辉瑞产品公司 恢复p53家族蛋白质的构象稳定性的方法和组合物
US7799904B2 (en) * 2003-06-13 2010-09-21 University Of Kentucky Research Foundation Gilvocarcin gene cluster, recombinant production and use thereof
US20070270504A1 (en) * 2003-06-20 2007-11-22 Avalon Pharmaceuticals, Inc. Identification of Therapeutic Agents Using Genetic Fingerprinting
JP2007284351A (ja) * 2004-07-27 2007-11-01 Osaka Bioscience Institute アミロイド蛋白質の凝集を抑制する物質とその作用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI93860C (fi) * 1991-03-25 1995-06-12 Leiras Oy Menetelmä antibioottien tuottamiseksi, siinä käyttökelpoisia DNA-jaksoja, yhdistelmä-DNA-konstruktioita ja näitä sisältäviä mikrobikantoja
KR0145943B1 (ko) * 1995-02-03 1998-08-01 김은영 아클라비논 c-11 히드록실라제, 그 유전자, 발현벡터 및 이를 이용한 하이브리드 항생제의 제조방법

Also Published As

Publication number Publication date
FI105554B (fi) 2000-09-15
JP2002514399A (ja) 2002-05-21
DE69909938D1 (de) 2003-09-04
DK1000078T3 (da) 2003-11-17
ES2205825T3 (es) 2004-05-01
EP1000078A1 (en) 2000-05-17
ATE246198T1 (de) 2003-08-15
WO1999058544A9 (en) 2000-01-20
US6399583B1 (en) 2002-06-04
FI981062A0 (fi) 1998-05-13
DE69909938T2 (de) 2004-05-13
WO1999058544A1 (en) 1999-11-18
EP1000078B1 (en) 2003-07-30

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