FI970317A - Som antiproliferativa ämnen och Garft-inhibitorer användbara föreningar - Google Patents
Som antiproliferativa ämnen och Garft-inhibitorer användbara föreningar Download PDFInfo
- Publication number
- FI970317A FI970317A FI970317A FI970317A FI970317A FI 970317 A FI970317 A FI 970317A FI 970317 A FI970317 A FI 970317A FI 970317 A FI970317 A FI 970317A FI 970317 A FI970317 A FI 970317A
- Authority
- FI
- Finland
- Prior art keywords
- compounds
- antiproliferative agents
- compounds useful
- garft inhibitors
- garft
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 230000001028 anti-proliverative effect Effects 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 title abstract 3
- 239000003944 phosphoribosylglycinamide formyltransferase inhibitor Substances 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28163994 | 1994-07-28 | ||
US08/281,639 US5608082A (en) | 1994-07-28 | 1994-07-28 | Compounds useful as antiproliferative agents and GARFT inhibitors |
PCT/US1995/009519 WO1996003406A1 (en) | 1994-07-28 | 1995-07-28 | Compounds useful as antiproliferative agents and garft inhibitors |
US9509519 | 1995-07-28 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI970317A0 FI970317A0 (sv) | 1997-01-24 |
FI970317A true FI970317A (sv) | 1997-03-05 |
FI112079B FI112079B (sv) | 2003-10-31 |
Family
ID=23078167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI970317A FI112079B (sv) | 1994-07-28 | 1997-01-24 | 2-(2-amino-4-okso-tetrahydropyrido[2,3-d]-pyridin- och pyrimido[5,4-b][1,4]tiazin-6-yl)etyl-4-metyltien-2-yl-L-glutaminsyraderivat |
Country Status (20)
Country | Link |
---|---|
US (2) | US5608082A (sv) |
EP (1) | EP0773943B1 (sv) |
JP (1) | JPH10503762A (sv) |
KR (1) | KR100380610B1 (sv) |
CN (2) | CN1091770C (sv) |
AT (1) | ATE206122T1 (sv) |
AU (1) | AU697138B2 (sv) |
CA (1) | CA2195420A1 (sv) |
DE (1) | DE69522945T2 (sv) |
DK (1) | DK0773943T3 (sv) |
ES (1) | ES2162933T3 (sv) |
FI (1) | FI112079B (sv) |
MX (1) | MX9700675A (sv) |
NO (1) | NO308248B1 (sv) |
NZ (1) | NZ290703A (sv) |
PT (1) | PT773943E (sv) |
RU (1) | RU2152945C2 (sv) |
SI (1) | SI0773943T1 (sv) |
TW (1) | TW432062B (sv) |
WO (1) | WO1996003406A1 (sv) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5831100A (en) * | 1995-06-07 | 1998-11-03 | Agouron Pharmaceuticals, Inc. | Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates |
CA2383524C (en) * | 1999-08-31 | 2010-09-28 | Merck & Co., Inc. | Thiazolyl alkynyl compounds and methods of use thereof |
US6774138B2 (en) | 1999-08-31 | 2004-08-10 | Merck & Co., Inc. | Thiazolyl(pyridyl)ethyne compounds |
WO2002078709A2 (en) * | 2001-02-16 | 2002-10-10 | Eli Lilly And Company | Use of pyrido`2,3-d pyrimidin derivatives for the treatment of human cytomegalovirus infections |
WO2003033478A1 (en) * | 2001-10-12 | 2003-04-24 | Warner-Lambert Company Llc | Alkynylated fused ring pyrimidine compounds as matrix metalloprotease-13 inhibitors |
CA2462442A1 (en) | 2001-10-12 | 2003-04-24 | Warner-Lambert Company Llc | Alkyne matrix metalloproteinase inhibitors |
WO2003033477A1 (en) * | 2001-10-12 | 2003-04-24 | Warner-Lambert Company Llc | Alkynlated fused ring pyrimidine compounds as matrix metalloprotease-13 inhibitor |
US6962922B2 (en) * | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
US20040043959A1 (en) * | 2002-03-04 | 2004-03-04 | Bloom Laura A. | Combination therapies for treating methylthioadenosine phosphorylase deficient cells |
US6747147B2 (en) | 2002-03-08 | 2004-06-08 | Warner-Lambert Company | Oxo-azabicyclic compounds |
US6894057B2 (en) * | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
US20040006077A1 (en) * | 2002-06-25 | 2004-01-08 | Bernard Gaudilliere | Thiazine and oxazine derivatives as MMP-13 inhibitors |
CA2489722A1 (en) * | 2002-07-17 | 2004-01-22 | William Howard Roark | Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib |
WO2004113337A1 (en) * | 2003-06-25 | 2004-12-29 | Pfizer Inc. | Convergent synthesis of a garft inhibitor containing a methyl substitute thiophene core and a tetrahydropyrido`2,3-d! pyrimidine ring system and intermediates therefor |
WO2004113328A1 (en) * | 2003-06-25 | 2004-12-29 | Pfizer Inc. | Convergent asymmetric synthesis route to produce a key intermediate towards the synthesis of a garft inhibitor |
WO2005016926A1 (en) * | 2003-08-19 | 2005-02-24 | Warner-Lambert Company Llc | Pyrido [3,4-d] pyrimidine derivatives as matrix metalloproteinase-13 inhibitors |
US7420059B2 (en) * | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
AU2006238930B2 (en) | 2005-04-26 | 2010-12-23 | Pfizer Inc. | P-cadherin antibodies |
ES2546069T3 (es) | 2005-09-07 | 2015-09-18 | Amgen Fremont Inc. | Anticuerpos monoclonales humanos para quinasa-1 de tipo receptor de activina (ALK-1) |
EP2021338A1 (en) | 2006-05-09 | 2009-02-11 | Pfizer Products Inc. | Cycloalkylamino acid derivatives and pharmaceutical compositions thereof |
US8252804B2 (en) | 2008-10-01 | 2012-08-28 | Duquesne University Of The Holy Spirit | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same |
LT2678327T (lt) | 2011-02-23 | 2016-11-25 | Lupin Limited | Heteroarilo dariniai kaip nachr alpha7 moduliatoriai |
GB201103578D0 (en) | 2011-03-02 | 2011-04-13 | Sabrepharm Ltd | Dipyridinium derivatives |
ES2606043T3 (es) | 2011-07-05 | 2017-03-17 | Lupin Limited | Derivados de biarilo como moduladores de nAChR |
EP2760820A4 (en) * | 2011-09-29 | 2015-04-29 | Univ Emory | SPHINGOSIN ANALOGS, COMPOSITIONS AND METHODS RELATED THERETO |
CA2866015A1 (en) | 2012-03-06 | 2013-09-12 | Lupin Limited | Thiazole derivatives as alpha 7 nachr modulators |
GB2543550A (en) | 2015-10-21 | 2017-04-26 | Hox Therapeutics Ltd | Peptides |
CN115634228B (zh) * | 2021-07-20 | 2024-03-19 | 首都医科大学 | 嘌呤合成抑制剂在制备治疗缺血和缺血再灌注损伤药物中的应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT376436B (de) * | 1982-11-05 | 1984-11-26 | Laevosan Gmbh & Co Kg | Verfahren zur herstellung neuer thiophen-2carbons[urederivate und pharmazeutisch vertraeglicher saeure- oder basenadditionssalze davon |
US4927828A (en) * | 1985-03-08 | 1990-05-22 | The Trustees Of Princeton University | Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivatives |
US4684653A (en) * | 1985-03-08 | 1987-08-04 | The Trustees Of Princeton University | Pyrido(2,3-d)pyrimidine derivatives |
US5026851A (en) * | 1985-03-08 | 1991-06-25 | The Trustees Of Princeton University | Pyrido[2,3-]pyrimidine derivatives |
US4831037A (en) * | 1987-04-20 | 1989-05-16 | The Trustees Of Princeton University | 4 (3H)-oxo-5,6,7,8-tetrahydropyrido-(2,3-d)pyrimidine derivatives |
US4988813A (en) * | 1986-10-20 | 1991-01-29 | The Trustees Of Princeton University | Process for the preparation of fused pyridine compounds |
US4895946A (en) * | 1987-10-26 | 1990-01-23 | The Trustees Of Princeton University | Process for the preparation of fused pyridine compounds |
US4889859A (en) * | 1988-02-05 | 1989-12-26 | The Trustees Of Princeton University | Pyrido[2,3-d]pyrimidine derivatives |
US4882334A (en) * | 1988-05-25 | 1989-11-21 | The Trustees Of Princeton University | N-(5,6,7,8-tetrahydropyrido]2,3-d]pyrimidin-6-ylethl-thineyl-and furylcarbonyl)-glutamic acid derivatives |
DK172753B1 (da) * | 1988-05-25 | 1999-06-28 | Lilly Co Eli | N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat |
US4882333A (en) * | 1988-05-25 | 1989-11-21 | The Trustess Of Princeton University | N-(5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives |
US4871746A (en) * | 1988-05-31 | 1989-10-03 | The Trustees Of Princeton University | N-[N-(tetrahydropyrido[2,3-D]pyrimidinylmethyl)-aminomethylbenzoyl]glutamic acid derivatives as neoplastic growth inhibitors |
US4883799A (en) * | 1988-06-29 | 1989-11-28 | The Trustees Of Princeton University | N-(4-(1-hydroxy-3-(5,6,7,8-tetrahydropyrido(2,3,-d)-pyrimidin-6-yl)prop-2-yl)benzoyl)glutamic acid derivatives |
EP0438261A3 (en) * | 1990-01-16 | 1992-02-26 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic glutamic acid derivatives, their production and use |
ZA917355B (en) * | 1990-09-17 | 1992-08-26 | Agouron Pharma | Antiproliferative substituted naphthalene compounds |
US5217974A (en) * | 1991-03-29 | 1993-06-08 | Eli Lilly And Company | Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity |
US5223503A (en) * | 1991-04-29 | 1993-06-29 | Eli Lilly And Company | 6-substituted pyrido[2,3-d]pyrimidines as antineoplastic agents |
US5969136A (en) * | 1992-10-15 | 1999-10-19 | Eli Lilly And Company | Cyclization for preparing antifolate compounds |
JPH08504765A (ja) * | 1992-12-16 | 1996-05-21 | アグロン・ファーマシュウティカルズ・インコーポレーテッド | 抗増殖性の置換5−チアピリミジノンおよび5−セレノピリミジノン化合物 |
-
1994
- 1994-07-28 US US08/281,639 patent/US5608082A/en not_active Expired - Fee Related
-
1995
- 1995-06-06 US US08/467,945 patent/US5646141A/en not_active Expired - Fee Related
- 1995-07-28 EP EP95927503A patent/EP0773943B1/en not_active Expired - Lifetime
- 1995-07-28 JP JP8505975A patent/JPH10503762A/ja not_active Withdrawn
- 1995-07-28 NZ NZ290703A patent/NZ290703A/en unknown
- 1995-07-28 SI SI9530534T patent/SI0773943T1/xx unknown
- 1995-07-28 ES ES95927503T patent/ES2162933T3/es not_active Expired - Lifetime
- 1995-07-28 KR KR1019970700588A patent/KR100380610B1/ko not_active IP Right Cessation
- 1995-07-28 PT PT95927503T patent/PT773943E/pt unknown
- 1995-07-28 CN CN95194376A patent/CN1091770C/zh not_active Expired - Fee Related
- 1995-07-28 AT AT95927503T patent/ATE206122T1/de not_active IP Right Cessation
- 1995-07-28 WO PCT/US1995/009519 patent/WO1996003406A1/en active IP Right Grant
- 1995-07-28 RU RU97103518/04A patent/RU2152945C2/ru not_active IP Right Cessation
- 1995-07-28 AU AU31517/95A patent/AU697138B2/en not_active Ceased
- 1995-07-28 CA CA002195420A patent/CA2195420A1/en not_active Abandoned
- 1995-07-28 DE DE69522945T patent/DE69522945T2/de not_active Expired - Fee Related
- 1995-07-28 MX MX9700675A patent/MX9700675A/es not_active IP Right Cessation
- 1995-07-28 DK DK95927503T patent/DK0773943T3/da active
-
1996
- 1996-01-29 TW TW085101051A patent/TW432062B/zh not_active IP Right Cessation
-
1997
- 1997-01-24 FI FI970317A patent/FI112079B/sv not_active IP Right Cessation
- 1997-01-27 NO NO970349A patent/NO308248B1/no not_active IP Right Cessation
-
2001
- 2001-12-05 CN CN01142735A patent/CN1394857A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
MX9700675A (es) | 1997-04-30 |
NO970349L (no) | 1997-03-12 |
CA2195420A1 (en) | 1996-02-08 |
ATE206122T1 (de) | 2001-10-15 |
AU3151795A (en) | 1996-02-22 |
CN1091770C (zh) | 2002-10-02 |
JPH10503762A (ja) | 1998-04-07 |
US5646141A (en) | 1997-07-08 |
RU2152945C2 (ru) | 2000-07-20 |
ES2162933T3 (es) | 2002-01-16 |
NO308248B1 (no) | 2000-08-21 |
TW432062B (en) | 2001-05-01 |
FI970317A0 (sv) | 1997-01-24 |
FI112079B (sv) | 2003-10-31 |
KR100380610B1 (ko) | 2003-08-27 |
PT773943E (pt) | 2002-01-30 |
EP0773943B1 (en) | 2001-09-26 |
AU697138B2 (en) | 1998-09-24 |
CN1394857A (zh) | 2003-02-05 |
DK0773943T3 (da) | 2002-03-04 |
SI0773943T1 (en) | 2001-12-31 |
US5608082A (en) | 1997-03-04 |
NZ290703A (en) | 1998-11-25 |
CN1154110A (zh) | 1997-07-09 |
DE69522945T2 (de) | 2002-03-28 |
EP0773943A1 (en) | 1997-05-21 |
WO1996003406A1 (en) | 1996-02-08 |
NO970349D0 (no) | 1997-01-27 |
DE69522945D1 (de) | 2001-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI970317A (sv) | Som antiproliferativa ämnen och Garft-inhibitorer användbara föreningar | |
DK0889877T3 (da) | Meta-substituerede phenylenderivater og deres anvendelse som alfav-beta3-integrin-antagonister eller -inhibitorer | |
DK0894084T3 (da) | Kanelsyrederivater og deres anvendelse som integrinantagonister | |
DE69830504D1 (de) | Antithrombotische mitteln | |
DE69705829D1 (de) | Meta-substituierte phenylsulphonamidderivate | |
DK2314582T3 (da) | Heterocykliske forbindelser som antivirusmidler | |
DE69705300T2 (de) | Cyclopropylalkansäurederivate | |
DE602004012758D1 (de) | Chinoxalinderivate als inhibitoren der neutrophilelastase und deren verwendung | |
NO20025641D0 (no) | Substituerte 1-aminoalkyl-laktamer og deres anvendelse som muscarin-reseptor-antagonister | |
NO20025640D0 (no) | Substituerte 1-aminoalkyl-laktamer og deres anvendelse som muscarin-reseptor-antagonister | |
NO20040881L (no) | Orale antidiabetes midler. | |
PT992509E (pt) | Novos derivados macrolidos | |
DK0902018T3 (da) | 2-(arylpheny)amino-imidazolinderivater | |
DE69330601D1 (de) | Serotoninergische ergolin derivate | |
NO20052413L (no) | Substituted aralkyl derivatives | |
FI970318A0 (sv) | Som antiproliferativa ämnen och Garft-inhibitorer användbara föreningar | |
DK0952157T3 (da) | 9a, 11b-dehydroderivater af 9-oxim-3-keto-6-0-methylerythromycin | |
CY1109966T1 (el) | Υποκατεστημενα αραλκυλοπαραγωγα |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |