FI963219A - Mykofenolihapon 4-aminojohdannaiset, joilla on immunosuppressanttiaktiivisuutta - Google Patents
Mykofenolihapon 4-aminojohdannaiset, joilla on immunosuppressanttiaktiivisuutta Download PDFInfo
- Publication number
- FI963219A FI963219A FI963219A FI963219A FI963219A FI 963219 A FI963219 A FI 963219A FI 963219 A FI963219 A FI 963219A FI 963219 A FI963219 A FI 963219A FI 963219 A FI963219 A FI 963219A
- Authority
- FI
- Finland
- Prior art keywords
- mycophenolic acid
- amino derivatives
- immunosuppressant activity
- immunosuppressant
- activity
- Prior art date
Links
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 title abstract 2
- 229960000951 mycophenolic acid Drugs 0.000 title abstract 2
- 230000001861 immunosuppressant effect Effects 0.000 title 1
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical class OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 abstract 1
- 229960004866 mycophenolate mofetil Drugs 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/198,817 US5380879A (en) | 1994-02-18 | 1994-02-18 | Derivatives of mycophenolic acid |
| PCT/US1995/001784 WO1995022535A1 (en) | 1994-02-18 | 1995-02-16 | 4-amino derivatives of mycophenolic acid with immunosuppressant activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI963219A0 FI963219A0 (fi) | 1996-08-16 |
| FI963219A true FI963219A (fi) | 1996-10-11 |
Family
ID=22734985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI963219A FI963219A (fi) | 1994-02-18 | 1996-08-16 | Mykofenolihapon 4-aminojohdannaiset, joilla on immunosuppressanttiaktiivisuutta |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US5380879A (fi) |
| EP (1) | EP0745074B1 (fi) |
| JP (1) | JPH09509171A (fi) |
| CN (1) | CN1143366A (fi) |
| AT (1) | ATE211467T1 (fi) |
| AU (1) | AU1916995A (fi) |
| BR (1) | BR9506820A (fi) |
| CA (1) | CA2183529A1 (fi) |
| CO (1) | CO4650136A1 (fi) |
| DE (1) | DE69524864T2 (fi) |
| DK (1) | DK0745074T3 (fi) |
| ES (1) | ES2170141T3 (fi) |
| FI (1) | FI963219A (fi) |
| IL (1) | IL112664A (fi) |
| MX (1) | MX9603479A (fi) |
| PT (1) | PT745074E (fi) |
| TW (1) | TW308591B (fi) |
| WO (1) | WO1995022535A1 (fi) |
| ZA (1) | ZA951292B (fi) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455045A (en) * | 1993-05-13 | 1995-10-03 | Syntex (U.S.A.) Inc. | High dose formulations |
| US5380879A (en) * | 1994-02-18 | 1995-01-10 | Syntex (U.S.A.) Inc. | Derivatives of mycophenolic acid |
| US5512568A (en) * | 1994-02-18 | 1996-04-30 | Syntex (U.S.A.) Inc. | Method of using 4-amino derivatives of 5-substituted mycophenolic acid |
| US5525602A (en) * | 1994-02-18 | 1996-06-11 | Syntex (U.S.A.) Inc. | Method of using 4-amino 6-substituted mycophenolic acid and derivatives |
| US6054472A (en) * | 1996-04-23 | 2000-04-25 | Vertex Pharmaceuticals, Incorporated | Inhibitors of IMPDH enzyme |
| US5807876A (en) * | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| KR100643057B1 (ko) * | 1996-04-23 | 2007-01-11 | 버텍스 파마슈티칼스 인코포레이티드 | Impdh효소억제제로서의우레아유도체 |
| CN1116288C (zh) | 1996-04-23 | 2003-07-30 | 沃泰克斯药物股份有限公司 | 用作肌苷－5'－一磷酸脱氢酶抑制剂的脲衍生物 |
| US6128582A (en) * | 1996-04-30 | 2000-10-03 | Vertex Pharmaceuticals Incorporated | Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them |
| ATE244717T1 (de) * | 1997-03-14 | 2003-07-15 | Vertex Pharma | Inhibitoren des impdh-enzyms |
| US5932600A (en) * | 1997-03-14 | 1999-08-03 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| AU3665199A (en) * | 1998-04-29 | 1999-11-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of impdh enzyme |
| CA2348234A1 (en) | 1998-10-29 | 2000-05-11 | Chunjian Liu | Compounds derived from an amine nucleus that are inhibitors of impdh enzyme |
| EP1127054A4 (en) * | 1998-10-29 | 2006-11-02 | Bristol Myers Squibb Co | INHIBITORS OF IMPDH ENZYME |
| US6420403B1 (en) | 1998-10-29 | 2002-07-16 | Edwin J. Iwanowicz | Inhibitors of IMPDH enzyme |
| US6596747B2 (en) | 1998-10-29 | 2003-07-22 | Bristol-Myers Squibb Company | Compounds derived from an amine nucleus and pharmaceutical compositions comprising same |
| MY125300A (en) * | 1999-02-26 | 2006-07-31 | Inst Of Molecular And Cell Biology | Synergistic combination for treatment of viral-mediated diseases |
| US6514979B1 (en) * | 1999-03-03 | 2003-02-04 | University Of Maryland Biotechnology Institute | Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor |
| PL211562B1 (pl) * | 1999-03-19 | 2012-05-31 | Vertex Pharma | Związki, zawierające je kompozycje oraz ich zastosowania |
| US6653309B1 (en) | 1999-04-26 | 2003-11-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme technical field of the invention |
| US6107052A (en) * | 1999-06-09 | 2000-08-22 | Roche Diagnostics Corporation | Enzymatic measurement of mycophenolic acid |
| US6395763B1 (en) | 1999-06-25 | 2002-05-28 | Vertex Pharmaceuticals Incorporated | Prodrugs of carbamate inhibitors of IMPDH |
| US6811998B2 (en) | 1999-06-25 | 2004-11-02 | Roche Diagnostics Operations, Inc. | Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase |
| CA2407370A1 (en) * | 2000-04-24 | 2001-11-01 | Bristol-Myers Squibb Company | Heterocycles that are inhibitors of impdh enzyme |
| CN1501828A (zh) * | 2000-12-15 | 2004-06-02 | ������˹ҩƷ��˾ | 用肌苷一磷酸脱氢酶抑制剂进行的dapd联合治疗 |
| WO2003035066A1 (en) * | 2001-10-23 | 2003-05-01 | Celltech R & D Limited | 2-aminoquinolone derivatives for use as impdh inhibitors |
| TW200301698A (en) * | 2001-12-21 | 2003-07-16 | Bristol Myers Squibb Co | Acridone inhibitors of IMPDH enzyme |
| WO2004012746A2 (en) * | 2002-08-02 | 2004-02-12 | The Regents Of The University Of California | New uses for inhibitors of inosine monophosphate dehydrogenase |
| TWI221414B (en) * | 2003-02-21 | 2004-10-01 | Chunghwa Chemical Synthesis & | Method of making mycophenolate mofetil using transesterification |
| US20050187170A1 (en) * | 2003-06-16 | 2005-08-25 | Biocryst Pharmaceuticals, Inc. | Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors |
| US7276362B2 (en) | 2004-01-30 | 2007-10-02 | Roche Diagnostics Operations, Inc. | Recombinant histidine-tagged inosine monophosphate dehydrogenase polypeptides |
| CN100402516C (zh) * | 2005-10-18 | 2008-07-16 | 深圳市东阳光实业发展有限公司 | 一种霉酚酸莫啡酯的制备方法 |
| WO2008033466A2 (en) * | 2006-09-14 | 2008-03-20 | Combinatorx (Singapore) Pre. Ltd. | Compositions and methods for treatment of viral diseases |
| CN102952105A (zh) * | 2011-08-26 | 2013-03-06 | 中国科学院上海药物研究所 | 一类霉酚酸衍生物、其制备方法和用途 |
| CN102391225B (zh) * | 2011-12-07 | 2013-07-31 | 中国科学院南海海洋研究所 | 霉酚酸衍生物a、b、c及其在制备免疫抑制药物中的应用 |
| WO2014146218A1 (zh) * | 2013-03-22 | 2014-09-25 | 当代绿能科技股份有限公司 | 马替麦考酚酯或其盐类用于制备抗流感病毒之药物的用途 |
| US12011429B2 (en) | 2016-06-02 | 2024-06-18 | Steven Baranowitz | Prevention and treatment of viral infections |
| US10603299B2 (en) | 2016-06-02 | 2020-03-31 | Steven Baranowitz | Prevention and treatment of viral infections |
| CA3026241A1 (en) | 2016-06-02 | 2017-12-07 | Steven Baranowitz | Prevention and treatment of viral infections |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3825571A (en) * | 1971-07-31 | 1974-07-23 | Chugai Pharmaceutical Co Ltd | Mycophenolic acid derivatives |
| JPS5542995B2 (fi) * | 1972-02-24 | 1980-11-04 | ||
| JPS5529994B2 (fi) * | 1972-03-02 | 1980-08-07 | ||
| US4686234A (en) * | 1985-11-27 | 1987-08-11 | Syntex (U.S.A) Inc. | Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis |
| US4725622A (en) * | 1986-01-23 | 1988-02-16 | Syntex (U.S.A.) Inc. | Mycophenolic acid derivatives in the treatment of rheumatoid arthritis |
| US4959387A (en) * | 1986-01-23 | 1990-09-25 | Syntex (U.S.A.) Inc. | Mycophenolic acid derivatives in the treatment of rheumatoid arthritis |
| US4753935A (en) * | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
| US4861776A (en) * | 1987-01-30 | 1989-08-29 | Syntex (U.S.A) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use |
| US4748173A (en) * | 1987-01-30 | 1988-05-31 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions |
| US4727069A (en) * | 1987-01-30 | 1988-02-23 | Syntex (U.S.A.) Inc. | Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions |
| JPH0637486B2 (ja) * | 1988-05-18 | 1994-05-18 | 三共株式会社 | 新規抗生物質フタレキシンおよびその製造法 |
| US5247083A (en) * | 1992-07-10 | 1993-09-21 | Syntex (U.S.A.) Inc. | Direct esterification of mycophenolic acid |
| US5380879A (en) * | 1994-02-18 | 1995-01-10 | Syntex (U.S.A.) Inc. | Derivatives of mycophenolic acid |
-
1994
- 1994-02-18 US US08/198,817 patent/US5380879A/en not_active Expired - Fee Related
- 1994-09-23 US US08/311,666 patent/US5441953A/en not_active Expired - Fee Related
-
1995
- 1995-02-16 ZA ZA951292A patent/ZA951292B/xx unknown
- 1995-02-16 CN CN95191656A patent/CN1143366A/zh active Pending
- 1995-02-16 BR BR9506820A patent/BR9506820A/pt not_active IP Right Cessation
- 1995-02-16 IL IL11266495A patent/IL112664A/xx not_active IP Right Cessation
- 1995-02-16 PT PT95911697T patent/PT745074E/pt unknown
- 1995-02-16 DE DE69524864T patent/DE69524864T2/de not_active Expired - Fee Related
- 1995-02-16 EP EP95911697A patent/EP0745074B1/en not_active Expired - Lifetime
- 1995-02-16 CO CO95005929A patent/CO4650136A1/es unknown
- 1995-02-16 DK DK95911697T patent/DK0745074T3/da active
- 1995-02-16 AU AU19169/95A patent/AU1916995A/en not_active Abandoned
- 1995-02-16 ES ES95911697T patent/ES2170141T3/es not_active Expired - Lifetime
- 1995-02-16 AT AT95911697T patent/ATE211467T1/de not_active IP Right Cessation
- 1995-02-16 CA CA002183529A patent/CA2183529A1/en not_active Abandoned
- 1995-02-16 MX MX9603479A patent/MX9603479A/es not_active IP Right Cessation
- 1995-02-16 JP JP7521865A patent/JPH09509171A/ja not_active Ceased
- 1995-02-16 TW TW084101406A patent/TW308591B/zh active
- 1995-02-16 WO PCT/US1995/001784 patent/WO1995022535A1/en active IP Right Grant
-
1996
- 1996-08-16 FI FI963219A patent/FI963219A/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69524864T2 (de) | 2002-08-08 |
| IL112664A0 (en) | 1995-05-26 |
| TW308591B (fi) | 1997-06-21 |
| US5441953A (en) | 1995-08-15 |
| IL112664A (en) | 1999-06-20 |
| DK0745074T3 (da) | 2002-04-22 |
| WO1995022535A1 (en) | 1995-08-24 |
| EP0745074A1 (en) | 1996-12-04 |
| DE69524864D1 (de) | 2002-02-07 |
| AU1916995A (en) | 1995-09-04 |
| FI963219A0 (fi) | 1996-08-16 |
| CO4650136A1 (es) | 1998-09-03 |
| JPH09509171A (ja) | 1997-09-16 |
| BR9506820A (pt) | 1997-09-09 |
| PT745074E (pt) | 2002-06-28 |
| ZA951292B (en) | 1996-08-16 |
| EP0745074B1 (en) | 2002-01-02 |
| ES2170141T3 (es) | 2002-08-01 |
| CA2183529A1 (en) | 1995-08-24 |
| CN1143366A (zh) | 1997-02-19 |
| ATE211467T1 (de) | 2002-01-15 |
| MX9603479A (es) | 1997-12-31 |
| US5380879A (en) | 1995-01-10 |
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| FI963219A0 (fi) | Mykofenolihapon 4-aminojohdannaiset, joilla on immunosuppressanttiaktiivisuutta | |
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| BR9506836A (pt) | Acidos micofenólicos 4-amino 6-substituidos e derivados com atividade imunossupressora | |
| FI963220A0 (fi) | 5-substituoidun mykofenolihapon 4-aminojohdannaiset | |
| MX9603483A (es) | Acido micofenolico 6-sustituido y derivados. |