FI955575A - Makromolekyylivarjoaine magneettiresonanssikuvaukseen - Google Patents

Makromolekyylivarjoaine magneettiresonanssikuvaukseen Download PDF

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Publication number
FI955575A
FI955575A FI955575A FI955575A FI955575A FI 955575 A FI955575 A FI 955575A FI 955575 A FI955575 A FI 955575A FI 955575 A FI955575 A FI 955575A FI 955575 A FI955575 A FI 955575A
Authority
FI
Finland
Prior art keywords
magnetic resonance
contrast agent
resonance imaging
macromolecular contrast
macromolecular
Prior art date
Application number
FI955575A
Other languages
English (en)
Swedish (sv)
Other versions
FI955575A0 (fi
Inventor
Robert C Brasch
Jefrey S Mann
Danute E Nitecki
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of FI955575A0 publication Critical patent/FI955575A0/fi
Publication of FI955575A publication Critical patent/FI955575A/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/281—Means for the use of in vitro contrast agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
FI955575A 1993-05-20 1995-11-17 Makromolekyylivarjoaine magneettiresonanssikuvaukseen FI955575A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6462893A 1993-05-20 1993-05-20
PCT/US1994/005597 WO1994027498A1 (en) 1993-05-20 1994-05-19 Macromolecular contrast media for mr imaging

Publications (2)

Publication Number Publication Date
FI955575A0 FI955575A0 (fi) 1995-11-17
FI955575A true FI955575A (fi) 1996-01-15

Family

ID=22057238

Family Applications (1)

Application Number Title Priority Date Filing Date
FI955575A FI955575A (fi) 1993-05-20 1995-11-17 Makromolekyylivarjoaine magneettiresonanssikuvaukseen

Country Status (8)

Country Link
US (2) US5811076A (fi)
EP (1) EP0699051A4 (fi)
JP (1) JPH09500365A (fi)
AU (1) AU6953294A (fi)
CA (1) CA2163232A1 (fi)
FI (1) FI955575A (fi)
NO (1) NO310773B1 (fi)
WO (1) WO1994027498A1 (fi)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5085793A (en) * 1992-09-04 1994-03-29 General Hospital Corporation, The Biocompatible polymers containing diagnostic or therapeutic moieties
US5605672A (en) * 1993-06-09 1997-02-25 The General Hospital Corporation Blood pool imaging composition and method of its use
JP4432000B2 (ja) 1996-12-23 2010-03-17 ブラッコ・リサーチ・ソシエテ・アノニム 患者の消化管の視覚化におけるｍｒｉ造影の増加用組成物
US6009342A (en) * 1997-02-28 1999-12-28 The Regents Of The University Of California Imaging method for the grading of tumors
JP2003526437A (ja) * 2000-03-13 2003-09-09 メディ−フィジックス・インコーポレイテッド ガス状過分極１２９Ｘｅの直接注射を使用する診断処置並びに関連するシステムおよび生成物
GB0007873D0 (en) * 2000-03-31 2000-05-17 Nycomed Imaging As Method
US7179450B2 (en) * 2001-09-20 2007-02-20 Medi-Physics, Inc. Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe
US7504364B2 (en) * 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
US20040137481A1 (en) * 2002-09-16 2004-07-15 Receptors Llc Artificial receptor building blocks, components, and kits
US20050037429A1 (en) * 2003-03-28 2005-02-17 Receptors Llc Artificial receptors including reversibly immobilized building blocks and methods
WO2005003326A2 (en) * 2003-03-28 2005-01-13 Receptors Llc. Artificial receptors including reversibly immobilized building blocks and methods
US20050037381A1 (en) * 2002-09-16 2005-02-17 Receptors Llc Artificial receptors, building blocks, and methods
US20050170385A1 (en) * 2002-09-16 2005-08-04 Receptors Llc Artificial receptors including gradients
US20050136483A1 (en) * 2003-09-03 2005-06-23 Receptors Llc Nanodevices employing combinatorial artificial receptors
US20060051802A1 (en) * 2002-09-16 2006-03-09 Receptors Llc Artificial receptors, building blocks, and methods
US8129330B2 (en) * 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US20040062748A1 (en) * 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
WO2004054623A1 (en) * 2002-12-16 2004-07-01 Amersham Health As Magnetic resonance imaging method and compounds for use in the method
KR101207247B1 (ko) 2003-01-06 2012-12-03 넥타르 테라퓨틱스 티올-선택성 수용성 중합체 유도체
US20050152842A1 (en) * 2003-12-24 2005-07-14 Chun Li Poly (L-glutamic acid) paramagnetic material complex and use as a biodegradable MRI contrast agent
WO2006029234A1 (en) * 2004-09-03 2006-03-16 Receptors Llc Combinatorial artificial receptors including tether building blocks
WO2006029383A2 (en) * 2004-09-11 2006-03-16 Receptors Llc Combinatorial artificial receptors including peptide building blocks
CA2603437A1 (en) * 2005-04-01 2006-10-12 The Board Of Regents Of The University Of Texas System Poly(peptide) as a chelator: methods of manufacture and uses
JP5518465B2 (ja) 2006-03-14 2014-06-11 マリンクロッド エルエルシー テトラアザ大員環誘導体の金属錯体
US20080096819A1 (en) * 2006-05-02 2008-04-24 Allozyne, Inc. Amino acid substituted molecules
CA2653748A1 (en) 2006-05-02 2007-11-15 Allozyne, Inc. Non-natural amino acid substituted polypeptides
CA2707840A1 (en) * 2007-08-20 2009-02-26 Allozyne, Inc. Amino acid substituted molecules
JP6182019B2 (ja) * 2013-08-21 2017-08-16 国立研究開発法人国立循環器病研究センター 高分子化造影剤
JP7138350B2 (ja) 2016-11-14 2022-09-16 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ． 共役連結体、該連結体を含有する細胞結合分子－薬物共役体、並びに該共役体及び連結体の使用及び製造方法
EP3954393A1 (en) 2020-08-13 2022-02-16 Bioasis Technologies Inc. Combination therapies for delivery across the blood brain barrier

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
GB8413849D0 (en) * 1984-05-31 1984-07-04 Amersham Int Plc Nmr contrast agents
GB2172030B (en) 1985-03-05 1988-03-16 Koshun Kaihatsu Kabushiki Kais Rock hammer for underwater use
GB8719042D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
GB8801646D0 (en) * 1988-01-26 1988-02-24 Nycomed As Chemical compounds
DE3806795A1 (de) 1988-02-29 1989-09-07 Schering Ag Polymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
GB8827956D0 (en) 1988-11-30 1989-01-05 Morgan C A Lock
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
US5230883A (en) * 1989-05-04 1993-07-27 Wisconsin Alumni Research Foundation Method for localization and treatment of tumors using polylysine complexes
US5346687A (en) * 1989-08-09 1994-09-13 Rhomed Incorporated Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging
US5650133A (en) * 1990-01-19 1997-07-22 Nycomed Salutar Macrocyclic polyaza dichelates linked through ring nitrogens via an amide or ester functionality
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
US5871710A (en) * 1992-09-04 1999-02-16 The General Hospital Corporation Graft co-polymer adducts of platinum (II) compounds
AU5085793A (en) * 1992-09-04 1994-03-29 General Hospital Corporation, The Biocompatible polymers containing diagnostic or therapeutic moieties
US5817292A (en) * 1992-10-14 1998-10-06 Nycomed Imaging As MR imaging compositions and methods
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US5559214A (en) * 1993-05-28 1996-09-24 Sterling Winthrop Inc. Unsymmetrical complexing agents and targeting immunoreagents useful in thearpeutic and diagnostic compositions and methods
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
US5534241A (en) * 1993-07-23 1996-07-09 Torchilin; Vladimir P. Amphipathic polychelating compounds and methods of use
US5958372A (en) * 1994-06-28 1999-09-28 Nycomed Imaging As Low viscosity chelating polymers for diagnostic imaging
US5801228A (en) * 1995-06-07 1998-09-01 Nycomed Imaging As Polymeric contrast agents for medical imaging

Also Published As

Publication number Publication date
US6312664B1 (en) 2001-11-06
EP0699051A4 (en) 1998-11-25
FI955575A0 (fi) 1995-11-17
NO954656D0 (no) 1995-11-17
EP0699051A1 (en) 1996-03-06
AU6953294A (en) 1994-12-20
CA2163232A1 (en) 1994-12-08
US5811076A (en) 1998-09-22
JPH09500365A (ja) 1997-01-14
NO954656L (no) 1996-01-19
WO1994027498A1 (en) 1994-12-08
NO310773B1 (no) 2001-08-27

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