FI95374B - Förfarande för framställning av terapeutiskt användbara 3-fenyl-5,6-dihydrobenz/C/akridin-7-karboxylsyraderivat - Google Patents
Förfarande för framställning av terapeutiskt användbara 3-fenyl-5,6-dihydrobenz/C/akridin-7-karboxylsyraderivat Download PDFInfo
- Publication number
- FI95374B FI95374B FI900365A FI900365A FI95374B FI 95374 B FI95374 B FI 95374B FI 900365 A FI900365 A FI 900365A FI 900365 A FI900365 A FI 900365A FI 95374 B FI95374 B FI 95374B
- Authority
- FI
- Finland
- Prior art keywords
- acridine
- carboxylic acid
- compounds
- acid
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (5)
1. Förfarande för framställning av terapeutiskt användbara föreningar med formeln I 5 R2 R1 (i) R5 väri
15 R1 är C02H eller C02Na; R2 är H; R3 är H, F, Cl, Br eller I; och R4 och R5 är bäda självständigt H eller R4 och R5 tillsammans är S förutsatt att, dä R1 är C02Na, är R3 inte 20 F; eller ett farmaceutiskt godtagbart sait därav, kännetecknat därav, att (a) ett isatin med formeln 6 25 r* tiet: H 30 . väri R2 och R3 betecknar samma som ovan, omsätts « (Pfitzingerreaktion) med (i) 6-fenyl-3,4-dihydro-l(2H)-naftalenon eller 35 (ii) ett keton med formeln 8 il au.· iiiu i:i » «· . > 95374 ^ (8) för att framställa en förening med formeln I, väri R1 är 10 C02H, och (b) den i steg (a) erhällna föreningen eventuellt omsätts med natriumhydroxid.
2. Förfarande enligt patentkrav 1, känne- t e c k n a t därav, att man framställer 5,6-dihydro-3-15 fenylbens[c]akridin-7-karboxylsyra eller ett natrlumsalt därav.
3. Förfarande enligt patentkrav 1, känne- t e c k n a t därav, att man framställer 5,6-dihydro-9-fluor-3-fenylbens[c]akridin-7-karboxylsyra eller ett nat-20 riumsalt därav.
4. Förfarande enligt patentkrav 1, känne- t e c k n a t därav, att man framställer 6,7-dihydro-3-fluor- [1] -bensotieno[2', 3' :4, 5]bens[ 1,2-c]akridin-5-kar-boxylsyra eller ett natrlumsalt därav. ..25
5. Förfarande enligt patentkrav 1, känne- t · t e c k n a t därav, att man framställer 6,7-dihydro-[l]-bensotieno[2',3’:4,5]bens[l,2-c]akridin-5-karboxylsyra eller ett natriumsalt därav. f
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30137989 | 1989-01-25 | ||
| US07/301,379 US4918077A (en) | 1989-01-25 | 1989-01-25 | 3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI900365A0 FI900365A0 (sv) | 1990-01-24 |
| FI95374B true FI95374B (sv) | 1995-10-13 |
| FI95374C FI95374C (sv) | 1996-01-25 |
Family
ID=23163099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI900365A FI95374C (sv) | 1989-01-25 | 1990-01-24 | Förfarande för framställning av terapeutiskt användbara 3-fenyl-5,6-dihydrobenz/C/akridin-7-karboxylsyraderivat |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US4918077A (sv) |
| EP (1) | EP0380038B1 (sv) |
| JP (1) | JPH0662572B2 (sv) |
| KR (1) | KR910006985B1 (sv) |
| AT (1) | ATE124399T1 (sv) |
| AU (1) | AU623481B2 (sv) |
| CA (1) | CA2007529A1 (sv) |
| DE (1) | DE69020368T2 (sv) |
| DK (1) | DK0380038T3 (sv) |
| ES (1) | ES2075074T3 (sv) |
| FI (1) | FI95374C (sv) |
| GR (1) | GR3016979T3 (sv) |
| HU (1) | HU205743B (sv) |
| IE (1) | IE68761B1 (sv) |
| IL (1) | IL93161A0 (sv) |
| MY (1) | MY104829A (sv) |
| NO (1) | NO176961C (sv) |
| NZ (1) | NZ232207A (sv) |
| PT (1) | PT92952B (sv) |
| RU (1) | RU1779247C (sv) |
| ZA (1) | ZA90545B (sv) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5135934A (en) * | 1990-07-06 | 1992-08-04 | Du Pont Merck Pharmaceutical Company | 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents |
| WO1993022286A1 (en) * | 1992-04-24 | 1993-11-11 | Kyowa Hakko Kogyo Co., Ltd. | Novel tetracyclic compound |
| US5807549A (en) * | 1993-05-21 | 1998-09-15 | Research Corporation Technologies, Inc. | Lymphocyte chemoattractant factor and uses thereof |
| US5428040A (en) * | 1993-08-31 | 1995-06-27 | The Du Pont Merck Pharmaceutical Company | Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents |
| US5646283A (en) * | 1993-09-28 | 1997-07-08 | Kyowa Hakko Kogyo Co., Ltd. | Tetracyclic compound |
| GB9400585D0 (en) * | 1994-01-13 | 1994-03-09 | Guest John D | Improvements in or relating to tube couplings |
| JP3141148B2 (ja) * | 1995-08-08 | 2001-03-05 | 大鵬薬品工業株式会社 | 縮合インダン誘導体及びその塩 |
| AU2896097A (en) * | 1996-05-10 | 1997-12-05 | Novartis Ag | Use of brequinar and derivatives in chronic rejection of allografts and xenotransplantation |
| US7847125B2 (en) * | 2007-11-16 | 2010-12-07 | Chemtura Corporation | Acridan derivatives as antioxidants |
| CN102351870B (zh) * | 2011-08-25 | 2014-03-12 | 中山大学 | 一种苯并吖啶衍生物的制备方法及其作为抗癌药物的用途 |
| US20160287549A1 (en) | 2013-11-22 | 2016-10-06 | Genzyme Corporation | Novel methods for treating neurodegenerative diseases |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE502610A (sv) * | 1950-04-18 | |||
| DE3483704D1 (de) * | 1983-07-22 | 1991-01-17 | Du Pont | Phenylchinolinsaeure und derivate als antitumormittel. |
| US4680299A (en) * | 1984-04-30 | 1987-07-14 | E.I. Du Pont De Nemours And Company | 2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof |
| US4847381A (en) * | 1987-08-31 | 1989-07-11 | American Cyanamid Company | 2-Phenyl-4-quinoline carboxylic acids |
-
1989
- 1989-01-25 US US07/301,379 patent/US4918077A/en not_active Expired - Lifetime
-
1990
- 1990-01-10 CA CA002007529A patent/CA2007529A1/en not_active Abandoned
- 1990-01-23 EP EP90101253A patent/EP0380038B1/en not_active Expired - Lifetime
- 1990-01-23 DE DE69020368T patent/DE69020368T2/de not_active Expired - Fee Related
- 1990-01-23 NZ NZ232207A patent/NZ232207A/xx unknown
- 1990-01-23 DK DK90101253.4T patent/DK0380038T3/da active
- 1990-01-23 AT AT90101253T patent/ATE124399T1/de not_active IP Right Cessation
- 1990-01-23 ES ES90101253T patent/ES2075074T3/es not_active Expired - Lifetime
- 1990-01-24 PT PT92952A patent/PT92952B/pt not_active IP Right Cessation
- 1990-01-24 NO NO900342A patent/NO176961C/no unknown
- 1990-01-24 FI FI900365A patent/FI95374C/sv not_active IP Right Cessation
- 1990-01-24 RU SU904742891A patent/RU1779247C/ru active
- 1990-01-24 IL IL93161A patent/IL93161A0/xx not_active IP Right Cessation
- 1990-01-24 JP JP2012772A patent/JPH0662572B2/ja not_active Expired - Lifetime
- 1990-01-24 KR KR1019900000801A patent/KR910006985B1/ko not_active IP Right Cessation
- 1990-01-24 IE IE26790A patent/IE68761B1/en not_active IP Right Cessation
- 1990-01-24 HU HU90255A patent/HU205743B/hu not_active IP Right Cessation
- 1990-01-25 AU AU48745/90A patent/AU623481B2/en not_active Ceased
- 1990-01-25 ZA ZA90545A patent/ZA90545B/xx unknown
- 1990-01-25 MY MYPI90000135A patent/MY104829A/en unknown
- 1990-02-01 US US07/473,507 patent/US5002954A/en not_active Expired - Fee Related
-
1995
- 1995-08-02 GR GR950402095T patent/GR3016979T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| TC | Name/ company changed in patent |
Owner name: DUPONT PHARMACEUTICALS COMPANY |
|
| MM | Patent lapsed |
Owner name: DU PONT PHARMACEUTICALS COMPANY |