ATE124399T1 - 3-phenyl-5,6-dihydro(c)-acridin-7-carboxylsäure und verwandte verbindungen als chemotherapeutische wirkstoffe gegen krebs. - Google Patents

3-phenyl-5,6-dihydro(c)-acridin-7-carboxylsäure und verwandte verbindungen als chemotherapeutische wirkstoffe gegen krebs.

Info

Publication number
ATE124399T1
ATE124399T1 AT90101253T AT90101253T ATE124399T1 AT E124399 T1 ATE124399 T1 AT E124399T1 AT 90101253 T AT90101253 T AT 90101253T AT 90101253 T AT90101253 T AT 90101253T AT E124399 T1 ATE124399 T1 AT E124399T1
Authority
AT
Austria
Prior art keywords
carboxylic acid
acridine
dihydro
phenyl
chemotherapeutic agents
Prior art date
Application number
AT90101253T
Other languages
German (de)
English (en)
Inventor
Carl Henry Behrens
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Application granted granted Critical
Publication of ATE124399T1 publication Critical patent/ATE124399T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT90101253T 1989-01-25 1990-01-23 3-phenyl-5,6-dihydro(c)-acridin-7-carboxylsäure und verwandte verbindungen als chemotherapeutische wirkstoffe gegen krebs. ATE124399T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/301,379 US4918077A (en) 1989-01-25 1989-01-25 3-phenyl-5,6-dihydrobenz(c)acridine-7-carboxylic acids and related compounds as cancer chemotherapeutic agents

Publications (1)

Publication Number Publication Date
ATE124399T1 true ATE124399T1 (de) 1995-07-15

Family

ID=23163099

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90101253T ATE124399T1 (de) 1989-01-25 1990-01-23 3-phenyl-5,6-dihydro(c)-acridin-7-carboxylsäure und verwandte verbindungen als chemotherapeutische wirkstoffe gegen krebs.

Country Status (21)

Country Link
US (2) US4918077A (sv)
EP (1) EP0380038B1 (sv)
JP (1) JPH0662572B2 (sv)
KR (1) KR910006985B1 (sv)
AT (1) ATE124399T1 (sv)
AU (1) AU623481B2 (sv)
CA (1) CA2007529A1 (sv)
DE (1) DE69020368T2 (sv)
DK (1) DK0380038T3 (sv)
ES (1) ES2075074T3 (sv)
FI (1) FI95374C (sv)
GR (1) GR3016979T3 (sv)
HU (1) HU205743B (sv)
IE (1) IE68761B1 (sv)
IL (1) IL93161A0 (sv)
MY (1) MY104829A (sv)
NO (1) NO176961C (sv)
NZ (1) NZ232207A (sv)
PT (1) PT92952B (sv)
RU (1) RU1779247C (sv)
ZA (1) ZA90545B (sv)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5135934A (en) * 1990-07-06 1992-08-04 Du Pont Merck Pharmaceutical Company 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
WO1993022286A1 (en) * 1992-04-24 1993-11-11 Kyowa Hakko Kogyo Co., Ltd. Novel tetracyclic compound
US5807549A (en) * 1993-05-21 1998-09-15 Research Corporation Technologies, Inc. Lymphocyte chemoattractant factor and uses thereof
US5428040A (en) * 1993-08-31 1995-06-27 The Du Pont Merck Pharmaceutical Company Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
US5646283A (en) * 1993-09-28 1997-07-08 Kyowa Hakko Kogyo Co., Ltd. Tetracyclic compound
GB9400585D0 (en) * 1994-01-13 1994-03-09 Guest John D Improvements in or relating to tube couplings
JP3141148B2 (ja) * 1995-08-08 2001-03-05 大鵬薬品工業株式会社 縮合インダン誘導体及びその塩
AU2896097A (en) * 1996-05-10 1997-12-05 Novartis Ag Use of brequinar and derivatives in chronic rejection of allografts and xenotransplantation
US7847125B2 (en) * 2007-11-16 2010-12-07 Chemtura Corporation Acridan derivatives as antioxidants
CN102351870B (zh) * 2011-08-25 2014-03-12 中山大学 一种苯并吖啶衍生物的制备方法及其作为抗癌药物的用途
US20160287549A1 (en) 2013-11-22 2016-10-06 Genzyme Corporation Novel methods for treating neurodegenerative diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE502610A (sv) * 1950-04-18
DE3483704D1 (de) * 1983-07-22 1991-01-17 Du Pont Phenylchinolinsaeure und derivate als antitumormittel.
US4680299A (en) * 1984-04-30 1987-07-14 E.I. Du Pont De Nemours And Company 2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof
US4847381A (en) * 1987-08-31 1989-07-11 American Cyanamid Company 2-Phenyl-4-quinoline carboxylic acids

Also Published As

Publication number Publication date
FI95374C (sv) 1996-01-25
US5002954A (en) 1991-03-26
NZ232207A (en) 1991-08-27
PT92952A (pt) 1990-07-31
EP0380038A3 (en) 1991-11-13
JPH02233661A (ja) 1990-09-17
HU205743B (en) 1992-06-29
KR910006985B1 (ko) 1991-09-14
PT92952B (pt) 1995-12-29
FI900365A0 (sv) 1990-01-24
ZA90545B (en) 1991-09-25
JPH0662572B2 (ja) 1994-08-17
DE69020368D1 (de) 1995-08-03
NO176961B (no) 1995-03-20
EP0380038A2 (en) 1990-08-01
EP0380038B1 (en) 1995-06-28
IL93161A0 (en) 1990-11-05
AU623481B2 (en) 1992-05-14
NO176961C (no) 1995-06-28
IE900267L (en) 1990-07-25
IE68761B1 (en) 1996-07-10
NO900342D0 (no) 1990-01-24
RU1779247C (ru) 1992-11-30
MY104829A (en) 1994-06-30
AU4874590A (en) 1990-08-02
HU900255D0 (en) 1990-03-28
ES2075074T3 (es) 1995-10-01
DK0380038T3 (da) 1995-08-28
FI95374B (sv) 1995-10-13
HUT53880A (en) 1990-12-28
CA2007529A1 (en) 1990-07-25
US4918077A (en) 1990-04-17
DE69020368T2 (de) 1995-11-09
NO900342L (no) 1990-07-26
KR900011735A (ko) 1990-08-02
GR3016979T3 (en) 1995-11-30

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties
EEK Proclamation as to paragraph 128 patent law
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee