FI943872A - 2,6-metono-2H-kinolitsinderivat som 5-HT3-receptorantagonist - Google Patents

2,6-metono-2H-kinolitsinderivat som 5-HT3-receptorantagonist Download PDF

Info

Publication number
FI943872A
FI943872A FI943872A FI943872A FI943872A FI 943872 A FI943872 A FI 943872A FI 943872 A FI943872 A FI 943872A FI 943872 A FI943872 A FI 943872A FI 943872 A FI943872 A FI 943872A
Authority
FI
Finland
Prior art keywords
cacicin
methano
derivative
receptor antagonist
antagonist
Prior art date
Application number
FI943872A
Other languages
English (en)
Finnish (fi)
Other versions
FI943872A0 (sv
FI105917B (sv
Inventor
Maurice Ward Gittos
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI943872A publication Critical patent/FI943872A/sv
Publication of FI943872A0 publication Critical patent/FI943872A0/sv
Application granted granted Critical
Publication of FI105917B publication Critical patent/FI105917B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI943872A 1992-02-24 1994-08-23 Förfarande för framställning av en terapeutiskt aktiv 5-klor-2,3-dihydro-2,2-dimetylbensofuran-7-karboxylsyra-oktahydro-3-hydroxi-2,6-metano-2H-kinolizin-8-ylester FI105917B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP92400474 1992-02-24
EP92400474 1992-02-24
PCT/US1993/000880 WO1993017019A1 (en) 1992-02-24 1993-02-03 2,6-methano-2h-quinolizin derivative as 5-ht3-receptor antagonist
US9300880 1993-02-03

Publications (3)

Publication Number Publication Date
FI943872A true FI943872A (sv) 1994-08-23
FI943872A0 FI943872A0 (sv) 1994-08-23
FI105917B FI105917B (sv) 2000-10-31

Family

ID=8211614

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943872A FI105917B (sv) 1992-02-24 1994-08-23 Förfarande för framställning av en terapeutiskt aktiv 5-klor-2,3-dihydro-2,2-dimetylbensofuran-7-karboxylsyra-oktahydro-3-hydroxi-2,6-metano-2H-kinolizin-8-ylester

Country Status (14)

Country Link
EP (1) EP0628043A1 (sv)
JP (1) JPH07504192A (sv)
KR (1) KR100287933B1 (sv)
AU (1) AU675060B2 (sv)
CA (1) CA2130563C (sv)
FI (1) FI105917B (sv)
HU (1) HU216831B (sv)
IL (1) IL104821A (sv)
MX (1) MX9300948A (sv)
NO (1) NO943101L (sv)
NZ (1) NZ249346A (sv)
TW (1) TW226374B (sv)
WO (1) WO1993017019A1 (sv)
ZA (1) ZA931146B (sv)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002537255A (ja) 1999-02-18 2002-11-05 ノバルティス アクチエンゲゼルシャフト リウマチ性炎症性プロセスに対する５−ｈｔ３レセプターアンタゴニストの全身的使用
ES2714198T3 (es) 2005-03-07 2019-05-27 Univ Chicago Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0329932B1 (en) * 1988-02-23 1995-10-18 Merrell Pharmaceuticals Inc. Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments
EP0517984A1 (en) * 1991-06-11 1992-12-16 Merrell Dow Pharmaceuticals Inc. Derivatives of amide analogs of certain methano bridged quinolizines

Also Published As

Publication number Publication date
MX9300948A (es) 1993-08-01
CA2130563C (en) 1997-11-11
HUT68249A (en) 1995-06-28
HU9402436D0 (en) 1994-10-28
EP0628043A1 (en) 1994-12-14
WO1993017019A1 (en) 1993-09-02
NO943101D0 (no) 1994-08-23
NZ249346A (en) 1995-10-26
JPH07504192A (ja) 1995-05-11
HU216831B (hu) 1999-09-28
TW226374B (sv) 1994-07-11
AU675060B2 (en) 1997-01-23
FI943872A0 (sv) 1994-08-23
KR100287933B1 (ko) 2001-05-02
FI105917B (sv) 2000-10-31
CA2130563A1 (en) 1993-09-02
AU3603493A (en) 1993-09-13
IL104821A0 (en) 1993-06-10
NO943101L (no) 1994-08-23
ZA931146B (en) 1993-09-14
KR950700297A (ko) 1995-01-16
IL104821A (en) 1997-01-10

Similar Documents

Publication Publication Date Title
DE69127791D1 (de) Diazabicyclononyl-Derivate als 5-HT3 Rezeptor Antagonisten
DK0804419T3 (da) Quinolinderivater som tachykinin NK 3-receptor-antagonister
DE69207351D1 (de) Fibrinogen-Rezeptor-Antagoniste
DE69431604D1 (de) Benzofuranderivate als tachykininantagonisten
DE69202721D1 (de) Substituierte Indenylverbindungen.
AU4718093A (en) Substituted amines as tachykinin receptor antagonists
KR900700569A (ko) 2,3-디플루오로벤젠 유도체
FI961628A0 (sv) Indolderivat som NMDA-antagonister
DE69207109D1 (de) Werkzeugmaschine
NO930306L (no) Nye 1,4-dihydropyridinderivater
DE69418045D1 (de) Amidderivate als 5ht1d rezeptor antagonisten
AU2759892A (en) N-aryl-n1-azabicyclo-ureas as 5-ht3 antagonists
FI951798A0 (sv) Bentzofurandervat som 5-HT1-liknande receptorantagonister
NO179550C (no) Tachykinin reseptorantagonister
FI941372A0 (sv) Anordning för en bom
FI943872A (sv) 2,6-metono-2H-kinolitsinderivat som 5-HT3-receptorantagonist
DE69211267D1 (de) Schweissmaschine
NO930262L (no) Bombesin-antagonister
FI943359A (sv) Azacykliska-heterocykliska föreningar som angiotensin II receptorantagonister
DE69216466D1 (de) Substituierte 2,3-Dihydroperimidine, als Beständigkeitsmittel
FI941118A0 (sv) Bensylimidazopyridinderivat som angiotensin II-receptorantagonist
DE69714019D1 (de) 1,4-dihydropyridin-verbindungen als bradykinin-antagonisten
DE69208043D1 (de) Zusammentragmaschine
GB2269747B (en) Aroyl-ureas as pharmaceuticals, particularly 5-ht3 antagonists
NO943547D0 (no) N-t-butyl-androst-3,5-dien-17 , polymorf A

Legal Events

Date Code Title Description
PC Transfer of assignment of patent

Owner name: AVENTIS INC.

Free format text: AVENTIS INC.

PC Transfer of assignment of patent

Owner name: AVENTISUB II INC.

Free format text: AVENTISUB II INC.

MA Patent expired