FI943872A - 2,6-methano-2H-cacicin derivative as a 5-HT3 receptor antagonist - Google Patents

2,6-methano-2H-cacicin derivative as a 5-HT3 receptor antagonist Download PDF

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Publication number
FI943872A
FI943872A FI943872A FI943872A FI943872A FI 943872 A FI943872 A FI 943872A FI 943872 A FI943872 A FI 943872A FI 943872 A FI943872 A FI 943872A FI 943872 A FI943872 A FI 943872A
Authority
FI
Finland
Prior art keywords
cacicin
methano
derivative
receptor antagonist
antagonist
Prior art date
Application number
FI943872A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI105917B (en
FI943872A0 (en
Inventor
Maurice Ward Gittos
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI943872A0 publication Critical patent/FI943872A0/en
Publication of FI943872A publication Critical patent/FI943872A/en
Application granted granted Critical
Publication of FI105917B publication Critical patent/FI105917B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI943872A 1992-02-24 1994-08-23 Process for the preparation of a therapeutically active 5-chloro-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acid octahydro-3-hydroxy-2,6-methano-2H-quinolizin-8-yl ester FI105917B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP92400474 1992-02-24
EP92400474 1992-02-24
PCT/US1993/000880 WO1993017019A1 (en) 1992-02-24 1993-02-03 2,6-methano-2h-quinolizin derivative as 5-ht3-receptor antagonist
US9300880 1993-02-03

Publications (3)

Publication Number Publication Date
FI943872A0 FI943872A0 (en) 1994-08-23
FI943872A true FI943872A (en) 1994-08-23
FI105917B FI105917B (en) 2000-10-31

Family

ID=8211614

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943872A FI105917B (en) 1992-02-24 1994-08-23 Process for the preparation of a therapeutically active 5-chloro-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acid octahydro-3-hydroxy-2,6-methano-2H-quinolizin-8-yl ester

Country Status (14)

Country Link
EP (1) EP0628043A1 (en)
JP (1) JPH07504192A (en)
KR (1) KR100287933B1 (en)
AU (1) AU675060B2 (en)
CA (1) CA2130563C (en)
FI (1) FI105917B (en)
HU (1) HU216831B (en)
IL (1) IL104821A (en)
MX (1) MX9300948A (en)
NO (1) NO943101L (en)
NZ (1) NZ249346A (en)
TW (1) TW226374B (en)
WO (1) WO1993017019A1 (en)
ZA (1) ZA931146B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002537255A (en) 1999-02-18 2002-11-05 ノバルティス アクチエンゲゼルシャフト Systemic use of 5-HT3 receptor antagonists for rheumatic inflammatory processes
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
MX2007010833A (en) 2005-03-07 2009-02-17 Univ Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration.
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0329932B1 (en) * 1988-02-23 1995-10-18 Merrell Pharmaceuticals Inc. Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments
EP0517984A1 (en) * 1991-06-11 1992-12-16 Merrell Dow Pharmaceuticals Inc. Derivatives of amide analogs of certain methano bridged quinolizines

Also Published As

Publication number Publication date
MX9300948A (en) 1993-08-01
KR100287933B1 (en) 2001-05-02
AU675060B2 (en) 1997-01-23
CA2130563A1 (en) 1993-09-02
HU216831B (en) 1999-09-28
JPH07504192A (en) 1995-05-11
WO1993017019A1 (en) 1993-09-02
FI105917B (en) 2000-10-31
FI943872A0 (en) 1994-08-23
NO943101D0 (en) 1994-08-23
IL104821A0 (en) 1993-06-10
NZ249346A (en) 1995-10-26
HU9402436D0 (en) 1994-10-28
KR950700297A (en) 1995-01-16
CA2130563C (en) 1997-11-11
TW226374B (en) 1994-07-11
NO943101L (en) 1994-08-23
EP0628043A1 (en) 1994-12-14
AU3603493A (en) 1993-09-13
ZA931146B (en) 1993-09-14
HUT68249A (en) 1995-06-28
IL104821A (en) 1997-01-10

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Owner name: AVENTIS INC.

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Owner name: AVENTISUB II INC.

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MA Patent expired