MX9300948A - A NOVEL ANTAGONIST OF THE 5HT3 RECEIVER - Google Patents
A NOVEL ANTAGONIST OF THE 5HT3 RECEIVERInfo
- Publication number
- MX9300948A MX9300948A MX9300948A MX9300948A MX9300948A MX 9300948 A MX9300948 A MX 9300948A MX 9300948 A MX9300948 A MX 9300948A MX 9300948 A MX9300948 A MX 9300948A MX 9300948 A MX9300948 A MX 9300948A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- receiver
- antagonist
- novel
- novel antagonist
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invención se relaciona con el octahidro 3-hidroxi-2,6-metano-2H-qunolizin-8-il éster del ácido 5-cloro-2,3-dihidro-2,2-dimetilbenzofuran-7-carbox ílico, un antagonista novedoso del receptor 5-HT3, con su método de preparación y con su uso final en la aplicación en el tratamiento de las náuseas y el vómito, en el tratamiento del dolor asociado con migraña, en el tratamiento de psicosis endógena alucinatoria del tipo manifestado en pacientes que sufren de esquizofrenia y manía, para el síndrome del intestino inflamatorio o irritable o para combatir el abuso de las drogas.This invention relates to 5-chloro-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acid 3-hydroxy-2,6-methane-2H-qunolizin-8-yl ester, an antagonist Novel 5-HT3 receptor, with its preparation method and with its final use in the application in the treatment of nausea and vomiting, in the treatment of pain associated with migraine, in the treatment of hallucinatory endogenous psychosis of the type manifested in patients suffering from schizophrenia and mania, for inflammatory or irritable bowel syndrome or to combat drug abuse.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92400474 | 1992-02-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9300948A true MX9300948A (en) | 1993-08-01 |
Family
ID=8211614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9300948A MX9300948A (en) | 1992-02-24 | 1993-02-22 | A NOVEL ANTAGONIST OF THE 5HT3 RECEIVER |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0628043A1 (en) |
JP (1) | JPH07504192A (en) |
KR (1) | KR100287933B1 (en) |
AU (1) | AU675060B2 (en) |
CA (1) | CA2130563C (en) |
FI (1) | FI105917B (en) |
HU (1) | HU216831B (en) |
IL (1) | IL104821A (en) |
MX (1) | MX9300948A (en) |
NO (1) | NO943101L (en) |
NZ (1) | NZ249346A (en) |
TW (1) | TW226374B (en) |
WO (1) | WO1993017019A1 (en) |
ZA (1) | ZA931146B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2672500A (en) | 1999-02-18 | 2000-09-04 | Novartis Ag | Systemic use of 5-ht3 receptor antagonists against rheumatic inflammatory processes |
US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
CN104248763A (en) | 2005-03-07 | 2014-12-31 | 芝加哥大学 | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE68924545T2 (en) * | 1988-02-23 | 1996-03-21 | Merrell Dow Pharma | Use of quinolizine and quinolizone derivatives for the manufacture of medicaments. |
EP0517984A1 (en) * | 1991-06-11 | 1992-12-16 | Merrell Dow Pharmaceuticals Inc. | Derivatives of amide analogs of certain methano bridged quinolizines |
-
1993
- 1993-02-03 KR KR1019940702945A patent/KR100287933B1/en not_active IP Right Cessation
- 1993-02-03 CA CA002130563A patent/CA2130563C/en not_active Expired - Lifetime
- 1993-02-03 AU AU36034/93A patent/AU675060B2/en not_active Expired
- 1993-02-03 NZ NZ249346A patent/NZ249346A/en not_active IP Right Cessation
- 1993-02-03 EP EP93904797A patent/EP0628043A1/en not_active Withdrawn
- 1993-02-03 HU HU9402436A patent/HU216831B/en unknown
- 1993-02-03 WO PCT/US1993/000880 patent/WO1993017019A1/en active IP Right Grant
- 1993-02-03 JP JP5514868A patent/JPH07504192A/en active Pending
- 1993-02-18 ZA ZA931146A patent/ZA931146B/en unknown
- 1993-02-19 TW TW082101189A patent/TW226374B/zh not_active IP Right Cessation
- 1993-02-22 MX MX9300948A patent/MX9300948A/en unknown
- 1993-02-22 IL IL10482193A patent/IL104821A/en not_active IP Right Cessation
-
1994
- 1994-08-23 FI FI943872A patent/FI105917B/en not_active IP Right Cessation
- 1994-08-23 NO NO943101A patent/NO943101L/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU3603493A (en) | 1993-09-13 |
FI105917B (en) | 2000-10-31 |
AU675060B2 (en) | 1997-01-23 |
HU9402436D0 (en) | 1994-10-28 |
NO943101D0 (en) | 1994-08-23 |
FI943872A (en) | 1994-08-23 |
CA2130563A1 (en) | 1993-09-02 |
HUT68249A (en) | 1995-06-28 |
HU216831B (en) | 1999-09-28 |
ZA931146B (en) | 1993-09-14 |
IL104821A (en) | 1997-01-10 |
IL104821A0 (en) | 1993-06-10 |
FI943872A0 (en) | 1994-08-23 |
CA2130563C (en) | 1997-11-11 |
WO1993017019A1 (en) | 1993-09-02 |
NO943101L (en) | 1994-08-23 |
KR950700297A (en) | 1995-01-16 |
EP0628043A1 (en) | 1994-12-14 |
JPH07504192A (en) | 1995-05-11 |
TW226374B (en) | 1994-07-11 |
NZ249346A (en) | 1995-10-26 |
KR100287933B1 (en) | 2001-05-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA199800340A1 (en) | DERIVATIVES OF PYRIMIDINE AS ANTAGONISTS 5HT2S | |
UA27776C2 (en) | Quinuclidine derivatives, pharmaceutically acceptable saults thereof which are substance p receptor antagonists in mammals, pharmaceutical composition possessing antagonist activity on substance p in mammals | |
EA199900045A1 (en) | DERIVATIVES OF SPIROPIPERIDINE AND THEIR USE AS THERAPEUTIC AGENTS | |
BR9609013A (en) | Nucleoside analog, and, compound. | |
MX9300977A (en) | HETEROBICICLIC COMPOUNDS. | |
MY132229A (en) | Indole derivatives as 5-ht receptor antagonist | |
ECSP941135A (en) | BENZACEPINE VASOPRESSIN TRICYCLIC ANTAGONISTS | |
PT100514A (en) | SUBSTITUTED 3-AMINOKINUCLIDINS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAINS | |
EA199800868A1 (en) | Condensed arylamidopyridines and pyrimidines, containing their pharmaceutical composition, method of treatment, intermediate compounds and method of their production | |
ES2184797T3 (en) | USE OF SEROTONINE ANTAGONISTS (5HT3) FOR THE TREATMENT OF FIBROMIALGIA. | |
DK0725782T3 (en) | A1 adenosine receptor agonists and antiagonists | |
ATE293448T1 (en) | BENZO(D)AZEPINE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS | |
MX9203320A (en) | ANTI-ALLERGIC COMPOSITION CONTAINING SWITTERION BICYCLE COMPOUNDS. | |
DE69413535D1 (en) | 1-PHENYLAL CANNON AS 5-HT4 RECEPTOR LIGANDE | |
MX9300948A (en) | A NOVEL ANTAGONIST OF THE 5HT3 RECEIVER | |
ES2174337T3 (en) | TOPICAL USE OF KAPPA OPIOID AGONISTS FOR THE TREATMENT OF EYE PAIN. | |
AR010984A1 (en) | NEW ESTERS OF PLEUROMUTILINE, AND THE ACID 1-AZABICICLO-4- CARBANILCARBANICO; PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. | |
ES556864A0 (en) | PROCEDURE FOR OBTAINING SUBSTITUTED BENZOPYRANS. | |
PT684816E (en) | ANTAGONIST COMPOSITIONS OF 5-HT2 UTEIS RECEPTOR IN THE TREATMENT OF VENOUS DISEASES | |
AU3422800A (en) | Use of 5-ht3 receptor antagonists | |
EA199800701A1 (en) | BENZO [S] QUINOLYSINUM DERIVATIVES, THEIR RECEIVING AND USE AS INHIBITORS 5a-REDUCTAZ | |
ES2121984T3 (en) | USE OF 5-HT4 ANTAGONISTS FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF URINARY INCONTINENCE. | |
ES2166462T3 (en) | ANTIGONISTS OF ENDOTHELINE RECEIVER. | |
MX9302985A (en) | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND PROPHYLAXIS OF ANXIETY. | |
ZA949545B (en) | Bicyclic carboxylic acid leukotriene by antagonists |