FI943234A - A variant of a human Kunitz-type protease inhibitor - Google Patents
A variant of a human Kunitz-type protease inhibitor Download PDFInfo
- Publication number
- FI943234A FI943234A FI943234A FI943234A FI943234A FI 943234 A FI943234 A FI 943234A FI 943234 A FI943234 A FI 943234A FI 943234 A FI943234 A FI 943234A FI 943234 A FI943234 A FI 943234A
- Authority
- FI
- Finland
- Prior art keywords
- variant
- protease inhibitor
- type protease
- human kunitz
- kunitz
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK9200002 | 1992-01-07 | ||
| DK9200340 | 1992-11-16 | ||
| PCT/DK1993/000005 WO1993014122A1 (en) | 1992-01-07 | 1993-01-07 | A human kunitz-type protease inhibitor variant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI943234A true FI943234A (en) | 1994-07-06 |
| FI943234A0 FI943234A0 (en) | 1994-07-06 |
Family
ID=26068350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI943234A FI943234A0 (en) | 1992-01-07 | 1994-07-06 | Human Kunitzt type protease inhibitor variant |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0621872A1 (en) |
| JP (1) | JPH07504891A (en) |
| AU (1) | AU675926B2 (en) |
| CA (1) | CA2127246A1 (en) |
| CZ (1) | CZ164494A3 (en) |
| FI (1) | FI943234A0 (en) |
| HU (1) | HUT70293A (en) |
| IL (1) | IL104324A0 (en) |
| NO (1) | NO942549L (en) |
| NZ (1) | NZ246570A (en) |
| RU (1) | RU94036773A (en) |
| WO (1) | WO1993014122A1 (en) |
| ZA (1) | ZA9396B (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455338A (en) | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
| CA2180954C (en) | 1994-01-11 | 2007-03-20 | William Markland | Inhibitors of human plasmin derived from the kunitz domains |
| JP3805785B2 (en) * | 1994-01-11 | 2006-08-09 | ダイアックス コープ． | Kallikrein-inhibiting Kunitz domain protein and its homologues |
| US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| US5795954A (en) * | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
| US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
| EP0774001B1 (en) * | 1994-08-05 | 2002-10-16 | Chiron Corporation | Production of tissue factor pathway inhibitor |
| US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
| US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
| EP0831893B1 (en) * | 1995-06-07 | 2003-05-07 | Chiron Corporation | Regulation of neutrophil elastase synthesis and release |
| US6242414B1 (en) | 1995-06-07 | 2001-06-05 | Chiron Corporation | Regulation of cytokine synthesis and release |
| US6521410B1 (en) * | 1998-08-25 | 2003-02-18 | Knut Kleesiek | Mutant of tissue factor pathway inhibitor, DNA sequence and use for detecting thrombotic disorders |
| CN1325889A (en) * | 2000-05-26 | 2001-12-12 | 上海博德基因开发有限公司 | Polypeptide-human kazal-type inhibitor 11 and polynucleotide for coding it |
| WO2003103475A2 (en) | 2002-06-07 | 2003-12-18 | Dyax Corp. | Prevention and reduction of blood loss |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| SI2386310T1 (en) | 2002-08-28 | 2019-03-29 | Dyax Corp. | Methods for preserving organs and tissues |
| US6989369B2 (en) | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| WO2005021557A2 (en) | 2003-08-29 | 2005-03-10 | Dyax Corp. | Poly-pegylated protease inhibitors |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| US7276480B1 (en) | 2005-12-30 | 2007-10-02 | Dyax Corp. | Prevention and reduction of blood loss |
| ES2773766T3 (en) | 2008-12-19 | 2020-07-14 | Baxalta GmbH | TFPI inhibitors and methods of use |
| CN102307594A (en) | 2009-01-06 | 2012-01-04 | 戴埃克斯有限公司 | Treatment of mucositis with kallikrein inhibitors |
| HUE039605T2 (en) | 2010-01-06 | 2019-01-28 | Dyax Corp | Plasma kallikrein binding proteins |
| AU2011227714B2 (en) | 2010-03-19 | 2014-09-04 | Takeda Pharmaceutical Company Limited | TFPI inhibitors and methods of use |
| KR102320178B1 (en) | 2011-01-06 | 2021-11-02 | 다케다 파머수티컬 컴패니 리미티드 | Plasma kallikrein binding proteins |
| AU2013235741C1 (en) | 2012-03-21 | 2017-12-21 | Takeda Pharmaceutical Company Limited | TFPI inhibitors and methods of use |
| NZ744233A (en) | 2015-12-11 | 2023-11-24 | Takeda Pharmaceuticals Co | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5106833A (en) * | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
| DK408089D0 (en) * | 1989-08-18 | 1989-08-18 | Novo Nordisk As | PROTEINS |
-
1993
- 1993-01-06 IL IL104324A patent/IL104324A0/en unknown
- 1993-01-07 CZ CZ941644A patent/CZ164494A3/en unknown
- 1993-01-07 EP EP93902106A patent/EP0621872A1/en not_active Withdrawn
- 1993-01-07 NZ NZ246570A patent/NZ246570A/en unknown
- 1993-01-07 JP JP5511993A patent/JPH07504891A/en active Pending
- 1993-01-07 RU RU94036773/13A patent/RU94036773A/en unknown
- 1993-01-07 AU AU33460/93A patent/AU675926B2/en not_active Ceased
- 1993-01-07 HU HU9401990A patent/HUT70293A/en unknown
- 1993-01-07 ZA ZA9396A patent/ZA9396B/en unknown
- 1993-01-07 WO PCT/DK1993/000005 patent/WO1993014122A1/en not_active Application Discontinuation
- 1993-01-07 CA CA002127246A patent/CA2127246A1/en not_active Abandoned
-
1994
- 1994-07-06 NO NO942549A patent/NO942549L/en unknown
- 1994-07-06 FI FI943234A patent/FI943234A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07504891A (en) | 1995-06-01 |
| NO942549D0 (en) | 1994-07-06 |
| HU9401990D0 (en) | 1994-09-28 |
| FI943234A0 (en) | 1994-07-06 |
| IL104324A0 (en) | 1993-05-13 |
| CZ164494A3 (en) | 1994-12-15 |
| EP0621872A1 (en) | 1994-11-02 |
| ZA9396B (en) | 1993-08-10 |
| CA2127246A1 (en) | 1993-07-22 |
| AU675926B2 (en) | 1997-02-27 |
| WO1993014122A1 (en) | 1993-07-22 |
| AU3346093A (en) | 1993-08-03 |
| RU94036773A (en) | 1996-09-27 |
| NZ246570A (en) | 1996-09-25 |
| HUT70293A (en) | 1995-09-28 |
| NO942549L (en) | 1994-09-07 |
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