FI942935A - Peptidien nukleiinihappoja ja niiden vaikutus geneettiseen materiaaliin - Google Patents

Peptidien nukleiinihappoja ja niiden vaikutus geneettiseen materiaaliin Download PDF

Info

Publication number
FI942935A
FI942935A FI942935A FI942935A FI942935A FI 942935 A FI942935 A FI 942935A FI 942935 A FI942935 A FI 942935A FI 942935 A FI942935 A FI 942935A FI 942935 A FI942935 A FI 942935A
Authority
FI
Finland
Prior art keywords
peptides
effect
nucleic acids
genetic material
genetic
Prior art date
Application number
FI942935A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI942935A0 (fi
Inventor
Stpehen A Thomson
Stewart A Noble
Daniel J Ricca
Original Assignee
Glaxo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Inc filed Critical Glaxo Inc
Publication of FI942935A0 publication Critical patent/FI942935A0/fi
Publication of FI942935A publication Critical patent/FI942935A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FI942935A 1991-12-18 1994-06-17 Peptidien nukleiinihappoja ja niiden vaikutus geneettiseen materiaaliin FI942935A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80966191A 1991-12-18 1991-12-18
PCT/US1992/010921 WO1993012129A1 (en) 1991-12-18 1992-12-17 Peptide nucleic acids and their effect on genetic material

Publications (2)

Publication Number Publication Date
FI942935A0 FI942935A0 (fi) 1994-06-17
FI942935A true FI942935A (fi) 1994-07-27

Family

ID=25201908

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942935A FI942935A (fi) 1991-12-18 1994-06-17 Peptidien nukleiinihappoja ja niiden vaikutus geneettiseen materiaaliin

Country Status (10)

Country Link
EP (1) EP0618923A4 (no)
JP (1) JPH07502509A (no)
AU (2) AU3325493A (no)
CA (1) CA2125966A1 (no)
FI (1) FI942935A (no)
MX (1) MX9207334A (no)
NO (1) NO942327D0 (no)
NZ (1) NZ246473A (no)
WO (1) WO1993012129A1 (no)
ZA (1) ZA929764B (no)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013121A1 (en) * 1991-12-24 1993-07-08 Isis Pharmaceuticals, Inc. Gapped 2' modified oligonucleotides
US6713602B1 (en) 1991-05-24 2004-03-30 Ole Buchardt Synthetic procedures for peptide nucleic acids
US6451968B1 (en) 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US7223833B1 (en) 1991-05-24 2007-05-29 Isis Pharmaceuticals, Inc. Peptide nucleic acid conjugates
US6441130B1 (en) 1991-05-24 2002-08-27 Isis Pharmaceuticals, Inc. Linked peptide nucleic acids
US6228982B1 (en) * 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US5700922A (en) * 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US6277603B1 (en) 1991-12-24 2001-08-21 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US6350853B1 (en) 1993-04-26 2002-02-26 Peter E. Nielsen Conjugated peptide nucleic acids having enhanced cellular uptake
US5527675A (en) * 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331012A1 (de) * 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
WO1995017403A1 (en) * 1993-12-22 1995-06-29 Perseptive Biosystems, Inc. Guanine synthons for peptide nucleic acid synthesis and method for production
US6133444A (en) * 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
DK145493D0 (da) * 1993-12-23 1993-12-23 Dako As Antistof
US5539083A (en) * 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
DE4408533A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag PNA-Synthese unter Verwendung einer basenlabilen Amino-Schutzgruppe
DE4408531A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag PNA-Synthese unter Verwendung einer gegen schwache Säuren labilen Amino-Schutzgruppe
DE4408534A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden
DE4427980A1 (de) * 1994-08-08 1996-02-15 Bayer Ag Nukleinsäuren-bindende Oligomere für Therapie und Diagnostik
ATE222589T1 (de) * 1994-10-06 2002-09-15 Isis Pharmaceuticals Inc Peptid-nukleinsäure-konjugate
AU4729796A (en) * 1994-12-28 1996-07-19 Peter E. Nielsen Peptide nucleic acid incorporating a chiral backbone
US6465650B1 (en) 1995-03-13 2002-10-15 Aventis Pharma Deutschland Gmbh Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
EP0840741B1 (en) * 1995-06-07 2004-04-28 Perseptive Biosystems, Inc. Pna-dna chimeras and pna synthons for their preparation
WO1997014793A1 (en) * 1995-10-20 1997-04-24 Trustees Of Boston University Nucleic acid clamps
DE19653646A1 (de) * 1996-12-20 1998-06-25 Hoechst Ag Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung
US6617422B1 (en) 1997-05-23 2003-09-09 Peter Nielsen Peptide nucleic acid monomers and oligomers
WO1998058256A1 (en) * 1997-06-16 1998-12-23 The University Of North Carolina At Chapel Hill PEPTIDO OLIGONUCLEOTIDES (PONs) AND THEIR COMBINATORIAL LIBRARIES
AU9064598A (en) * 1998-07-10 2000-02-01 Harald Groger Precusors for pna-monomers
US6921812B1 (en) 2001-07-03 2005-07-26 Isis Pharmaceuticals, Inc. Methods of modulating pharmacokinetics of oligonucleotides
HUE033832T2 (en) 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
WO2007073149A1 (en) 2005-12-22 2007-06-28 Keygene N.V. Alternative nucleotides for improved targeted nucleotide exchange
WO2012113775A1 (en) 2011-02-21 2012-08-30 University Of Zurich Ankyrin g and modulators thereof for the treatment of neurodegenerative disorders
WO2014152054A1 (en) 2013-03-15 2014-09-25 Bio-Rad Laboratories, Inc. Digital assays for mutation detection
AU2018240467B2 (en) * 2017-03-23 2022-09-15 Neubase Therapeutics, Inc. Peptide nucleic acid (PNA) monomers with an orthogonally protected ester moiety

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0639582B1 (en) * 1985-03-15 1998-09-16 Antivirals Inc. Polynucleotide assay reagent and method
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf

Also Published As

Publication number Publication date
MX9207334A (es) 1993-08-01
NO942327L (no) 1994-08-17
NZ246473A (en) 1996-05-28
CA2125966A1 (en) 1993-06-24
ZA929764B (en) 1993-10-13
WO1993012129A1 (en) 1993-06-24
FI942935A0 (fi) 1994-06-17
EP0618923A4 (en) 1998-05-20
JPH07502509A (ja) 1995-03-16
NO942327D0 (no) 1994-06-17
EP0618923A1 (en) 1994-10-12
AU7032596A (en) 1997-01-16
AU3325493A (en) 1993-07-19

Similar Documents

Publication Publication Date Title
FI942935A (fi) Peptidien nukleiinihappoja ja niiden vaikutus geneettiseen materiaaliin
FI963185A0 (fi) Hematopoieettinen proteiini ja materiaalit ja menetelmät sen valmistamiseksi
FI972821A (fi) Geneettisesti ohjatun solukuoleman geenit ja proteiinit
FI934128A0 (fi) Nya inkapslade material
NO943344L (no) MN-gen og -protein
FI97941C (fi) Substraattimateriaali tupakointituotteita varten
FI963254A (fi) Alifaattinen polyesterihartsi ja menetelmä sen valmistamiseksi
FI954602A (fi) Koostumukset ja menetelmät käyttää ehdollisesti letaaleja geenejä
FI944440A (fi) Kuivakemateriaalit eläimiä varten
FI952324A (fi) Heterosykliset karbamaatit, menetelmä niiden valmistamiseksi ja lääkkeet
FI893452A0 (fi) Anordning foer separering och transport av material.
FI944906A (fi) Uudet sykliset aminohapot ja niiden johdannaiset
FI921714A0 (fi) Muovimateriaali pakkauksia varten
GB9023149D0 (en) Proteins and nucleic acids
FI912093A (fi) Laite jauhetun materiaalin käsittelemiseksi
FI941783A (fi) Sähköä johtava materiaali ja menetelmä sen valmistamiseksi
FI954769A (fi) Menetelmä ja laite prosessivalvontaa varten
FI973951A (fi) Taipuisa levymäinen tuote ja sen valmistusmenetelmä
FI925851A0 (fi) Viljan lajittelija
FI942722A0 (fi) Tunnistin ja menetelmä valittujen komponenttien materiaalin mittaamiseksi
FI103824B1 (fi) Laite ja menetelmä lumimaisen materiaalin muokkaamiseksi
FI933272A0 (fi) Anordning foer foerformning av plasticerat plastmaterial
FI954708A0 (fi) Muovautuvan materiaalin jakelulaite
GB9105446D0 (en) Proteins and nucleic acids
FI912763A (fi) Rekombinanta-dna och foerfarande foer framstaellning av chimaera antikroppar.

Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: ISIS PHARMACEUTICALS, INC.