AU7032596A - Peptide nucleic acids and their effect on genetic material - Google Patents

Peptide nucleic acids and their effect on genetic material

Info

Publication number
AU7032596A
AU7032596A AU70325/96A AU7032596A AU7032596A AU 7032596 A AU7032596 A AU 7032596A AU 70325/96 A AU70325/96 A AU 70325/96A AU 7032596 A AU7032596 A AU 7032596A AU 7032596 A AU7032596 A AU 7032596A
Authority
AU
Australia
Prior art keywords
effect
nucleic acids
genetic material
peptide nucleic
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU70325/96A
Inventor
Stewart A Noble
Daniel J. Ricca
Stephen A Thomson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Glaxo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Inc filed Critical Glaxo Inc
Publication of AU7032596A publication Critical patent/AU7032596A/en
Assigned to ISIS PHARMACEUTICALS, INC. reassignment ISIS PHARMACEUTICALS, INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: GLAXO INC.
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU70325/96A 1991-12-18 1996-10-21 Peptide nucleic acids and their effect on genetic material Abandoned AU7032596A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80966191A 1991-12-18 1991-12-18
US809661 1991-12-18

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU33254/93A Division AU3325493A (en) 1991-12-18 1992-12-17 Peptide nucleic acids and their effect on genetic material

Publications (1)

Publication Number Publication Date
AU7032596A true AU7032596A (en) 1997-01-16

Family

ID=25201908

Family Applications (2)

Application Number Title Priority Date Filing Date
AU33254/93A Abandoned AU3325493A (en) 1991-12-18 1992-12-17 Peptide nucleic acids and their effect on genetic material
AU70325/96A Abandoned AU7032596A (en) 1991-12-18 1996-10-21 Peptide nucleic acids and their effect on genetic material

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU33254/93A Abandoned AU3325493A (en) 1991-12-18 1992-12-17 Peptide nucleic acids and their effect on genetic material

Country Status (10)

Country Link
EP (1) EP0618923A4 (en)
JP (1) JPH07502509A (en)
AU (2) AU3325493A (en)
CA (1) CA2125966A1 (en)
FI (1) FI942935A (en)
MX (1) MX9207334A (en)
NO (1) NO942327D0 (en)
NZ (1) NZ246473A (en)
WO (1) WO1993012129A1 (en)
ZA (1) ZA929764B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6228982B1 (en) * 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
DK51092D0 (en) 1991-05-24 1992-04-15 Ole Buchardt OLIGONUCLEOTIDE ANALOGUE DESCRIBED BY PEN, MONOMERIC SYNTHONES AND PROCEDURES FOR PREPARING THEREOF, AND APPLICATIONS THEREOF
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US6441130B1 (en) 1991-05-24 2002-08-27 Isis Pharmaceuticals, Inc. Linked peptide nucleic acids
US6713602B1 (en) 1991-05-24 2004-03-30 Ole Buchardt Synthetic procedures for peptide nucleic acids
US7223833B1 (en) 1991-05-24 2007-05-29 Isis Pharmaceuticals, Inc. Peptide nucleic acid conjugates
US6451968B1 (en) 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US6277603B1 (en) 1991-12-24 2001-08-21 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US5700922A (en) * 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
ATE515510T1 (en) * 1991-12-24 2011-07-15 Isis Pharmaceuticals Inc OLIGONUCLEOTIDES MODIFIED BY DNA SECTIONS
US6350853B1 (en) 1993-04-26 2002-02-26 Peter E. Nielsen Conjugated peptide nucleic acids having enhanced cellular uptake
US5527675A (en) * 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331012A1 (en) * 1993-09-13 1995-03-16 Bayer Ag Nucleic acid-binding oligomers with N-branching for therapy and diagnostics
WO1995017403A1 (en) * 1993-12-22 1995-06-29 Perseptive Biosystems, Inc. Guanine synthons for peptide nucleic acid synthesis and method for production
US6133444A (en) 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
DK145493D0 (en) * 1993-12-23 1993-12-23 Dako As ANTIBODY
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
DE4408531A1 (en) * 1994-03-14 1995-09-28 Hoechst Ag PNA synthesis using an amino protecting group labile to weak acids
DE4408533A1 (en) * 1994-03-14 1995-09-28 Hoechst Ag PNA synthesis using a base-labile amino protecting group
DE4408534A1 (en) * 1994-03-14 1995-09-28 Hoechst Ag Substituted N-ethyl-glycine derivatives for the production of PNA and PNA / DNA hybrids
DE4427980A1 (en) * 1994-08-08 1996-02-15 Bayer Ag Nucleic acid binding oligomers for therapy and diagnostics
EP0804456B1 (en) * 1994-10-06 2002-08-21 Isis Pharmaceuticals, Inc. Peptide nucleic acid conjugates
WO1996020212A2 (en) * 1994-12-28 1996-07-04 Buchardt, Dorte Peptide nucleic acid incorporating a chiral backbone
US6465650B1 (en) 1995-03-13 2002-10-15 Aventis Pharma Deutschland Gmbh Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
JP2001518054A (en) * 1995-06-07 2001-10-09 パーセプティブ バイオシステムズ，インコーポレーテッド PNA-DNA chimera and PNA synthon for chimera synthesis
AU7016096A (en) * 1995-10-20 1997-05-07 Trustees Of Boston University Nucleic acid clamps
DE19653646A1 (en) * 1996-12-20 1998-06-25 Hoechst Ag Substituted purine derivatives, processes for their preparation, agents containing them and their use
US6617422B1 (en) 1997-05-23 2003-09-09 Peter Nielsen Peptide nucleic acid monomers and oligomers
AU8147798A (en) * 1997-06-16 1999-01-04 University Of North Carolina At Chapel Hill, The Peptido oligonucleotides (pons) and their combinatorial libraries
AU9064598A (en) * 1998-07-10 2000-02-01 Harald Groger Precusors for pna-monomers
US6921812B1 (en) 2001-07-03 2005-07-26 Isis Pharmaceuticals, Inc. Methods of modulating pharmacokinetics of oligonucleotides
KR20050088079A (en) 2002-11-15 2005-09-01 이데닉스 (케이만) 리미티드 2'-branched nucleosides and flaviviridae mutation
WO2007073149A1 (en) 2005-12-22 2007-06-28 Keygene N.V. Alternative nucleotides for improved targeted nucleotide exchange
WO2012113775A1 (en) 2011-02-21 2012-08-30 University Of Zurich Ankyrin g and modulators thereof for the treatment of neurodegenerative disorders
EP2971160B1 (en) 2013-03-15 2018-05-30 Bio-Rad Laboratories, Inc. Digital assays for mutation detection
JP2020511550A (en) * 2017-03-23 2020-04-16 トゥルーコード ジーン リペアー， インコーポレイテッド Peptide nucleic acid (PNA) monomer with orthogonal protected ester moieties

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3650349T2 (en) * 1985-03-15 1995-12-14 Antivirals Inc IMMUNOTEST FOR POLYNUCLEOTID AND METHOD.
DK51092D0 (en) * 1991-05-24 1992-04-15 Ole Buchardt OLIGONUCLEOTIDE ANALOGUE DESCRIBED BY PEN, MONOMERIC SYNTHONES AND PROCEDURES FOR PREPARING THEREOF, AND APPLICATIONS THEREOF

Also Published As

Publication number Publication date
NO942327L (en) 1994-08-17
FI942935A (en) 1994-07-27
AU3325493A (en) 1993-07-19
MX9207334A (en) 1993-08-01
FI942935A0 (en) 1994-06-17
EP0618923A4 (en) 1998-05-20
ZA929764B (en) 1993-10-13
WO1993012129A1 (en) 1993-06-24
NO942327D0 (en) 1994-06-17
CA2125966A1 (en) 1993-06-24
JPH07502509A (en) 1995-03-16
EP0618923A1 (en) 1994-10-12
NZ246473A (en) 1996-05-28

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