EP0618923A4 - Peptide nucleic acids and their effect on genetic material. - Google Patents

Peptide nucleic acids and their effect on genetic material.

Info

Publication number
EP0618923A4
EP0618923A4 EP93901215A EP93901215A EP0618923A4 EP 0618923 A4 EP0618923 A4 EP 0618923A4 EP 93901215 A EP93901215 A EP 93901215A EP 93901215 A EP93901215 A EP 93901215A EP 0618923 A4 EP0618923 A4 EP 0618923A4
Authority
EP
European Patent Office
Prior art keywords
effect
nucleic acids
genetic material
peptide nucleic
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93901215A
Other languages
German (de)
French (fr)
Other versions
EP0618923A1 (en
Inventor
Stephen A Thomson
Stewart A Noble
Daniel J Ricca
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Glaxo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Inc filed Critical Glaxo Inc
Publication of EP0618923A1 publication Critical patent/EP0618923A1/en
Publication of EP0618923A4 publication Critical patent/EP0618923A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP93901215A 1991-12-18 1992-12-17 Peptide nucleic acids and their effect on genetic material. Withdrawn EP0618923A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80966191A 1991-12-18 1991-12-18
US809661 1991-12-18
PCT/US1992/010921 WO1993012129A1 (en) 1991-12-18 1992-12-17 Peptide nucleic acids and their effect on genetic material

Publications (2)

Publication Number Publication Date
EP0618923A1 EP0618923A1 (en) 1994-10-12
EP0618923A4 true EP0618923A4 (en) 1998-05-20

Family

ID=25201908

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93901215A Withdrawn EP0618923A4 (en) 1991-12-18 1992-12-17 Peptide nucleic acids and their effect on genetic material.

Country Status (10)

Country Link
EP (1) EP0618923A4 (en)
JP (1) JPH07502509A (en)
AU (2) AU3325493A (en)
CA (1) CA2125966A1 (en)
FI (1) FI942935A (en)
MX (1) MX9207334A (en)
NO (1) NO942327D0 (en)
NZ (1) NZ246473A (en)
WO (1) WO1993012129A1 (en)
ZA (1) ZA929764B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6228982B1 (en) * 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
US6451968B1 (en) 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
DK51092D0 (en) 1991-05-24 1992-04-15 Ole Buchardt OLIGONUCLEOTIDE ANALOGUE DESCRIBED BY PEN, MONOMERIC SYNTHONES AND PROCEDURES FOR PREPARING THEREOF, AND APPLICATIONS THEREOF
US6441130B1 (en) 1991-05-24 2002-08-27 Isis Pharmaceuticals, Inc. Linked peptide nucleic acids
US6713602B1 (en) 1991-05-24 2004-03-30 Ole Buchardt Synthetic procedures for peptide nucleic acids
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US7223833B1 (en) 1991-05-24 2007-05-29 Isis Pharmaceuticals, Inc. Peptide nucleic acid conjugates
US6277603B1 (en) 1991-12-24 2001-08-21 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US5700922A (en) * 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
EP1044987B1 (en) * 1991-12-24 2006-02-15 Isis Pharmaceuticals, Inc. Gapped 2'-modified oligonucleotides
US6350853B1 (en) 1993-04-26 2002-02-26 Peter E. Nielsen Conjugated peptide nucleic acids having enhanced cellular uptake
US5527675A (en) * 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331012A1 (en) * 1993-09-13 1995-03-16 Bayer Ag Nucleic acid-binding oligomers with N-branching for therapy and diagnostics
US6133444A (en) * 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
DE69430704T2 (en) * 1993-12-22 2003-01-30 Perseptive Biosystems Inc GUANINE SYNTHONES FOR THE SYNTHESIS OF NUCLEIC ACIDS AND METHOD FOR THE PRODUCTION THEREOF
DK145493D0 (en) * 1993-12-23 1993-12-23 Dako As ANTIBODY
US5539083A (en) * 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
DE4408531A1 (en) * 1994-03-14 1995-09-28 Hoechst Ag PNA synthesis using an amino protecting group labile to weak acids
DE4408533A1 (en) * 1994-03-14 1995-09-28 Hoechst Ag PNA synthesis using a base-labile amino protecting group
DE4408534A1 (en) * 1994-03-14 1995-09-28 Hoechst Ag Substituted N-ethyl-glycine derivatives for the production of PNA and PNA / DNA hybrids
DE4427980A1 (en) * 1994-08-08 1996-02-15 Bayer Ag Nucleic acid binding oligomers for therapy and diagnostics
JP3307945B2 (en) * 1994-10-06 2002-07-29 アイシス・ファーマシューティカルス・インコーポレーテッド Peptide nucleic acid conjugate
AU4729796A (en) * 1994-12-28 1996-07-19 Peter E. Nielsen Peptide nucleic acid incorporating a chiral backbone
US6465650B1 (en) 1995-03-13 2002-10-15 Aventis Pharma Deutschland Gmbh Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
EP0840741B1 (en) * 1995-06-07 2004-04-28 Perseptive Biosystems, Inc. Pna-dna chimeras and pna synthons for their preparation
WO1997014793A1 (en) * 1995-10-20 1997-04-24 Trustees Of Boston University Nucleic acid clamps
DE19653646A1 (en) * 1996-12-20 1998-06-25 Hoechst Ag Substituted purine derivatives, processes for their preparation, agents containing them and their use
US6617422B1 (en) 1997-05-23 2003-09-09 Peter Nielsen Peptide nucleic acid monomers and oligomers
AU8147798A (en) * 1997-06-16 1999-01-04 University Of North Carolina At Chapel Hill, The Peptido oligonucleotides (pons) and their combinatorial libraries
WO2000002864A1 (en) * 1998-07-10 2000-01-20 Martens Juergen Precusors for pna-monomers
US6921812B1 (en) 2001-07-03 2005-07-26 Isis Pharmaceuticals, Inc. Methods of modulating pharmacokinetics of oligonucleotides
HUE033832T2 (en) 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and flaviviridae mutation
WO2007073149A1 (en) 2005-12-22 2007-06-28 Keygene N.V. Alternative nucleotides for improved targeted nucleotide exchange
WO2012113775A1 (en) 2011-02-21 2012-08-30 University Of Zurich Ankyrin g and modulators thereof for the treatment of neurodegenerative disorders
US9347095B2 (en) 2013-03-15 2016-05-24 Bio-Rad Laboratories, Inc. Digital assays for mutation detection
CN110740994A (en) * 2017-03-23 2020-01-31 特鲁科德基因修复公司 Peptide Nucleic Acid (PNA) monomers with orthogonally protected ester moieties

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986005518A1 (en) * 1985-03-15 1986-09-25 James Summerton Stereoregular polynucleotide-binding polymers
WO1992020702A1 (en) * 1991-05-24 1992-11-26 Ole Buchardt Peptide nucleic acids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986005518A1 (en) * 1985-03-15 1986-09-25 James Summerton Stereoregular polynucleotide-binding polymers
WO1992020702A1 (en) * 1991-05-24 1992-11-26 Ole Buchardt Peptide nucleic acids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9312129A1 *

Also Published As

Publication number Publication date
NO942327L (en) 1994-08-17
FI942935A0 (en) 1994-06-17
CA2125966A1 (en) 1993-06-24
ZA929764B (en) 1993-10-13
FI942935A (en) 1994-07-27
AU3325493A (en) 1993-07-19
NO942327D0 (en) 1994-06-17
JPH07502509A (en) 1995-03-16
NZ246473A (en) 1996-05-28
MX9207334A (en) 1993-08-01
EP0618923A1 (en) 1994-10-12
AU7032596A (en) 1997-01-16
WO1993012129A1 (en) 1993-06-24

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Legal Events

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Owner name: GLAXO WELLCOME INC.

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Effective date: 19991230