FI942935A - Nucleic acids for peptides and their effect on genetic material - Google Patents

Nucleic acids for peptides and their effect on genetic material Download PDF

Info

Publication number
FI942935A
FI942935A FI942935A FI942935A FI942935A FI 942935 A FI942935 A FI 942935A FI 942935 A FI942935 A FI 942935A FI 942935 A FI942935 A FI 942935A FI 942935 A FI942935 A FI 942935A
Authority
FI
Finland
Prior art keywords
peptides
effect
nucleic acids
genetic material
genetic
Prior art date
Application number
FI942935A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI942935A0 (en
Inventor
Stpehen A Thomson
Stewart A Noble
Daniel J Ricca
Original Assignee
Glaxo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Inc filed Critical Glaxo Inc
Publication of FI942935A0 publication Critical patent/FI942935A0/en
Publication of FI942935A publication Critical patent/FI942935A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FI942935A 1991-12-18 1994-06-17 Nucleic acids for peptides and their effect on genetic material FI942935A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80966191A 1991-12-18 1991-12-18
PCT/US1992/010921 WO1993012129A1 (en) 1991-12-18 1992-12-17 Peptide nucleic acids and their effect on genetic material

Publications (2)

Publication Number Publication Date
FI942935A0 FI942935A0 (en) 1994-06-17
FI942935A true FI942935A (en) 1994-07-27

Family

ID=25201908

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942935A FI942935A (en) 1991-12-18 1994-06-17 Nucleic acids for peptides and their effect on genetic material

Country Status (10)

Country Link
EP (1) EP0618923A4 (en)
JP (1) JPH07502509A (en)
AU (2) AU3325493A (en)
CA (1) CA2125966A1 (en)
FI (1) FI942935A (en)
MX (1) MX9207334A (en)
NO (1) NO942327D0 (en)
NZ (1) NZ246473A (en)
WO (1) WO1993012129A1 (en)
ZA (1) ZA929764B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7223833B1 (en) 1991-05-24 2007-05-29 Isis Pharmaceuticals, Inc. Peptide nucleic acid conjugates
US6713602B1 (en) 1991-05-24 2004-03-30 Ole Buchardt Synthetic procedures for peptide nucleic acids
US6451968B1 (en) 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
DK51092D0 (en) 1991-05-24 1992-04-15 Ole Buchardt OLIGONUCLEOTIDE ANALOGUE DESCRIBED BY PEN, MONOMERIC SYNTHONES AND PROCEDURES FOR PREPARING THEREOF, AND APPLICATIONS THEREOF
US6441130B1 (en) 1991-05-24 2002-08-27 Isis Pharmaceuticals, Inc. Linked peptide nucleic acids
US6228982B1 (en) * 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US6277603B1 (en) 1991-12-24 2001-08-21 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
ATE515510T1 (en) * 1991-12-24 2011-07-15 Isis Pharmaceuticals Inc OLIGONUCLEOTIDES MODIFIED BY DNA SECTIONS
US5700922A (en) * 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US6350853B1 (en) 1993-04-26 2002-02-26 Peter E. Nielsen Conjugated peptide nucleic acids having enhanced cellular uptake
US5527675A (en) * 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331012A1 (en) * 1993-09-13 1995-03-16 Bayer Ag Nucleic acid-binding oligomers with N-branching for therapy and diagnostics
JPH11503713A (en) * 1993-12-22 1999-03-30 パーセプティブ・バイオシステムズ・インコーポレーテッド Guanine synthon for peptide nucleic acid synthesis and method for preparing the same
US6133444A (en) 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
DK145493D0 (en) * 1993-12-23 1993-12-23 Dako As ANTIBODY
US5539083A (en) * 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
DE4408531A1 (en) * 1994-03-14 1995-09-28 Hoechst Ag PNA synthesis using an amino protecting group labile to weak acids
DE4408534A1 (en) * 1994-03-14 1995-09-28 Hoechst Ag Substituted N-ethyl-glycine derivatives for the production of PNA and PNA / DNA hybrids
DE4408533A1 (en) * 1994-03-14 1995-09-28 Hoechst Ag PNA synthesis using a base-labile amino protecting group
DE4427980A1 (en) * 1994-08-08 1996-02-15 Bayer Ag Nucleic acid binding oligomers for therapy and diagnostics
PT804456E (en) * 1994-10-06 2003-01-31 Peter Eigil Nielsen CONJUGATES OF NUCLEIC ACIDS OF PEPTIDES
WO1996020212A2 (en) * 1994-12-28 1996-07-04 Buchardt, Dorte Peptide nucleic acid incorporating a chiral backbone
US6465650B1 (en) 1995-03-13 2002-10-15 Aventis Pharma Deutschland Gmbh Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
JP2001518054A (en) * 1995-06-07 2001-10-09 パーセプティブ バイオシステムズ，インコーポレーテッド PNA-DNA chimera and PNA synthon for chimera synthesis
AU7016096A (en) * 1995-10-20 1997-05-07 Trustees Of Boston University Nucleic acid clamps
DE19653646A1 (en) * 1996-12-20 1998-06-25 Hoechst Ag Substituted purine derivatives, processes for their preparation, agents containing them and their use
US6617422B1 (en) 1997-05-23 2003-09-09 Peter Nielsen Peptide nucleic acid monomers and oligomers
WO1998058256A1 (en) * 1997-06-16 1998-12-23 The University Of North Carolina At Chapel Hill PEPTIDO OLIGONUCLEOTIDES (PONs) AND THEIR COMBINATORIAL LIBRARIES
WO2000002864A1 (en) * 1998-07-10 2000-01-20 Martens Juergen Precusors for pna-monomers
US6921812B1 (en) 2001-07-03 2005-07-26 Isis Pharmaceuticals, Inc. Methods of modulating pharmacokinetics of oligonucleotides
CN1849142A (en) 2002-11-15 2006-10-18 埃迪尼克斯(开曼)有限公司 2'-branched nucleosides and flaviviridae mutation
WO2007073149A1 (en) 2005-12-22 2007-06-28 Keygene N.V. Alternative nucleotides for improved targeted nucleotide exchange
WO2012113775A1 (en) 2011-02-21 2012-08-30 University Of Zurich Ankyrin g and modulators thereof for the treatment of neurodegenerative disorders
WO2014152054A1 (en) 2013-03-15 2014-09-25 Bio-Rad Laboratories, Inc. Digital assays for mutation detection
US20180282375A1 (en) * 2017-03-23 2018-10-04 Trucode Gene Repair, Inc. Peptide nucleic acid (pna) monomers with an orthogonally protected ester moiety

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0215942B1 (en) * 1985-03-15 1995-07-12 Antivirals Inc. Polynucleotide assay reagent and method
DK51092D0 (en) * 1991-05-24 1992-04-15 Ole Buchardt OLIGONUCLEOTIDE ANALOGUE DESCRIBED BY PEN, MONOMERIC SYNTHONES AND PROCEDURES FOR PREPARING THEREOF, AND APPLICATIONS THEREOF

Also Published As

Publication number Publication date
FI942935A0 (en) 1994-06-17
EP0618923A4 (en) 1998-05-20
AU3325493A (en) 1993-07-19
ZA929764B (en) 1993-10-13
WO1993012129A1 (en) 1993-06-24
NO942327D0 (en) 1994-06-17
EP0618923A1 (en) 1994-10-12
JPH07502509A (en) 1995-03-16
NZ246473A (en) 1996-05-28
CA2125966A1 (en) 1993-06-24
NO942327L (en) 1994-08-17
AU7032596A (en) 1997-01-16
MX9207334A (en) 1993-08-01

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Owner name: ISIS PHARMACEUTICALS, INC.