FI942345A - Menetelmä proliiniboronaattiesterin valmistamiseksi - Google Patents

Menetelmä proliiniboronaattiesterin valmistamiseksi Download PDF

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Publication number
FI942345A
FI942345A FI942345A FI942345A FI942345A FI 942345 A FI942345 A FI 942345A FI 942345 A FI942345 A FI 942345A FI 942345 A FI942345 A FI 942345A FI 942345 A FI942345 A FI 942345A
Authority
FI
Finland
Prior art keywords
preparation
boronate ester
proline boronate
proline
ester
Prior art date
Application number
FI942345A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI942345A0 (fi
Inventor
Roger Snow
Terence A Kelly
Julian Adams
Simon Coutts
Clark Perry
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of FI942345A0 publication Critical patent/FI942345A0/fi
Publication of FI942345A publication Critical patent/FI942345A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI942345A 1991-11-22 1994-05-20 Menetelmä proliiniboronaattiesterin valmistamiseksi FI942345A (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79614891A 1991-11-22 1991-11-22
US93619892A 1992-08-26 1992-08-26
PCT/US1992/009845 WO1993010127A1 (en) 1991-11-22 1992-11-19 Method for making a prolineboronate ester

Publications (2)

Publication Number Publication Date
FI942345A0 FI942345A0 (fi) 1994-05-20
FI942345A true FI942345A (fi) 1994-05-20

Family

ID=27121696

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942345A FI942345A (fi) 1991-11-22 1994-05-20 Menetelmä proliiniboronaattiesterin valmistamiseksi

Country Status (17)

Country Link
EP (1) EP0641347A1 (pt)
JP (1) JPH07501078A (pt)
CN (1) CN1073946A (pt)
AU (1) AU661362B2 (pt)
CA (1) CA2123128A1 (pt)
CZ (1) CZ124494A3 (pt)
FI (1) FI942345A (pt)
HU (1) HUT67937A (pt)
IL (1) IL103817A0 (pt)
MX (1) MX9206628A (pt)
NO (1) NO941905L (pt)
NZ (1) NZ245207A (pt)
PT (1) PT101079A (pt)
SI (1) SI9200332A (pt)
SK (1) SK59294A3 (pt)
TW (1) TW232697B (pt)
WO (1) WO1993010127A1 (pt)

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* Cited by examiner, † Cited by third party
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US6825169B1 (en) 1991-10-22 2004-11-30 Trustees Of Tufts College Inhibitors of dipeptidyl-aminopeptidase type IV
US5965532A (en) * 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
US6040145A (en) 1997-05-07 2000-03-21 Tufts University Potentiation of the immune response
US6100234A (en) 1997-05-07 2000-08-08 Tufts University Treatment of HIV
DE69837393T2 (de) 1997-09-29 2007-12-06 Point Therapeutics, Inc., Boston Stimulierung von hämatopoietischen zellen im vitro
KR20010052302A (ko) 1998-05-04 2001-06-25 바바라 피. 월너 조혈 자극
PT1084129E (pt) 1998-06-05 2003-06-30 Point Therapeutics Inc Compostos de boroprolina ciclica
US6979697B1 (en) 1998-08-21 2005-12-27 Point Therapeutics, Inc. Regulation of substrate activity
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
EP1259246A2 (en) * 2000-02-25 2002-11-27 Novo Nordisk A/S Use of dpp-iv inhibitors for the treatment of diabetes
WO2003063903A2 (en) * 2002-02-01 2003-08-07 Probiodrug Ag Modulation of t lymphocytes using dp iv inhibitors
KR20070054762A (ko) * 2003-11-12 2007-05-29 페노믹스 코포레이션 헤테로시클릭 보론산 화합물
US7317109B2 (en) 2003-11-12 2008-01-08 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US7767828B2 (en) 2003-11-12 2010-08-03 Phenomix Corporation Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US7576121B2 (en) 2003-11-12 2009-08-18 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
MXPA06005518A (es) 2003-11-17 2006-08-17 Novartis Ag Uso de inhibidores de la dipeptidil peptidasa iv.
WO2005067976A2 (en) 2004-01-20 2005-07-28 Novartis Ag Direct compression formulation and process
US7446211B2 (en) 2004-04-27 2008-11-04 Wyeth Coupling process for generating reactive boron-containing derivatives of N-substituted pyrrole-2-carbonitriles to produce biaryls
DOP2006000008A (es) 2005-01-10 2006-08-31 Arena Pharm Inc Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
US7399869B2 (en) 2005-05-19 2008-07-15 Genentech, Inc. Fibroblast activation protein inhibitor compounds and methods
US7825139B2 (en) 2005-05-25 2010-11-02 Forest Laboratories Holdings Limited (BM) Compounds and methods for selective inhibition of dipeptidyl peptidase-IV
CN1331835C (zh) * 2005-10-18 2007-08-15 武汉大学 光活性β－羟基酮的制备方法
KR20080077024A (ko) 2005-12-19 2008-08-20 트러스티즈 오브 터프츠 칼리지 소프트 단백질분해효소 억제자 및 이의 프로-소프트 폼
KR101281962B1 (ko) 2006-04-11 2013-07-08 아레나 파마슈티칼스, 인크. 특정 개체에게서 골 질량을 증가시키는 데에 유용한 화합물을 확인하기 위해 ｇｐｒ119 수용체를 사용하는 방법
PE20071221A1 (es) 2006-04-11 2007-12-14 Arena Pharm Inc Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
EP2108960A1 (en) 2008-04-07 2009-10-14 Arena Pharmaceuticals, Inc. Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY
GEP20135847B (en) 2008-06-17 2013-06-10 Millennium Pharm Inc Boronate ester compounds and pharmaceutical compositions containing them
AR077642A1 (es) 2009-07-09 2011-09-14 Arena Pharm Inc Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
US20130023494A1 (en) 2010-04-06 2013-01-24 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
EP2619198A1 (en) 2010-09-22 2013-07-31 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012135570A1 (en) 2011-04-01 2012-10-04 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
US20140066369A1 (en) 2011-04-19 2014-03-06 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
US20140038889A1 (en) 2011-04-22 2014-02-06 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
WO2012145604A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013055910A1 (en) 2011-10-12 2013-04-18 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2014074668A1 (en) 2012-11-08 2014-05-15 Arena Pharmaceuticals, Inc. Modulators of gpr119 and the treatment of disorders related thereto
US9523687B2 (en) 2014-02-28 2016-12-20 Institut Pasteur Levels of CXCL 10/IP-10 forms and soluble CD26/DPPIV activity as early predictive biomarkers for HIV/SIV associated mucosal inflammation and progression towards AIDS
SG10202003693RA (en) 2014-05-20 2020-05-28 Millennium Pharm Inc Boron-containing proteasome inhibitors for use after primary cancer therapy
SG10202103552XA (en) 2015-03-09 2021-05-28 Intekrin Therapeutics Inc Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy
WO2018162722A1 (en) 2017-03-09 2018-09-13 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Dpp-4 inhibitors for use in treating bone fractures
AU2018249822A1 (en) 2017-04-03 2019-10-31 Coherus Biosciences Inc. PPArgamma agonist for treatment of progressive supranuclear palsy
CN108047257B (zh) * 2017-12-17 2020-03-13 沧州普瑞东方科技有限公司 一种手性n-boc-吡咯烷-2-硼酸的制备工艺
CN110452258B (zh) * 2019-09-03 2021-01-01 上海馨远医药科技有限公司 一种二肽缬氨酸硼脯氨酸盐的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935493A (en) * 1987-10-06 1990-06-19 E. I. Du Pont De Nemours And Company Protease inhibitors
ATE148130T1 (de) * 1990-04-14 1997-02-15 New England Medical Center Inc Typ-iv-dipeptidyl-aminopeptidase-inhibitoren
GB9017694D0 (en) * 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry

Also Published As

Publication number Publication date
AU661362B2 (en) 1995-07-20
CA2123128A1 (en) 1993-05-27
NO941905L (no) 1994-07-14
IL103817A0 (en) 1993-04-04
FI942345A0 (fi) 1994-05-20
CZ124494A3 (en) 1995-07-12
SI9200332A (en) 1993-06-30
PT101079A (pt) 1994-02-28
NO941905D0 (no) 1994-05-20
CN1073946A (zh) 1993-07-07
AU3136893A (en) 1993-06-15
WO1993010127A1 (en) 1993-05-27
HU9401350D0 (en) 1994-08-29
HUT67937A (en) 1995-05-29
NZ245207A (en) 1994-07-26
JPH07501078A (ja) 1995-02-02
MX9206628A (es) 1993-05-01
EP0641347A1 (en) 1995-03-08
TW232697B (pt) 1994-10-21
SK59294A3 (en) 1995-02-08

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