FI940503A - Kinuklidinderivat som skvalensyntetasinhibitorer - Google Patents

Kinuklidinderivat som skvalensyntetasinhibitorer Download PDF

Info

Publication number
FI940503A
FI940503A FI940503A FI940503A FI940503A FI 940503 A FI940503 A FI 940503A FI 940503 A FI940503 A FI 940503A FI 940503 A FI940503 A FI 940503A FI 940503 A FI940503 A FI 940503A
Authority
FI
Finland
Prior art keywords
derivatives
pct
treating
date
alkylcarbamoyl
Prior art date
Application number
FI940503A
Other languages
English (en)
Finnish (fi)
Other versions
FI940503A0 (sv
Inventor
Keith Blakeney Mallion
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of FI940503A publication Critical patent/FI940503A/sv
Publication of FI940503A0 publication Critical patent/FI940503A0/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
FI940503A 1992-06-04 1994-02-03 Kinuklidinderivat som skvalensyntetasinhibitorer FI940503A0 (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929211796A GB9211796D0 (en) 1992-06-04 1992-06-04 Heterocyclic derivatives
PCT/GB1993/001165 WO1993024486A1 (en) 1992-06-04 1993-06-02 Quinuclidine derivatives as squalene synthetase inhibitors

Publications (2)

Publication Number Publication Date
FI940503A true FI940503A (sv) 1994-02-03
FI940503A0 FI940503A0 (sv) 1994-02-03

Family

ID=10716501

Family Applications (1)

Application Number Title Priority Date Filing Date
FI940503A FI940503A0 (sv) 1992-06-04 1994-02-03 Kinuklidinderivat som skvalensyntetasinhibitorer

Country Status (14)

Country Link
US (1) US5554613A (sv)
EP (1) EP0598093B1 (sv)
JP (1) JPH06509590A (sv)
AT (1) ATE160348T1 (sv)
AU (1) AU670295B2 (sv)
CA (1) CA2097671A1 (sv)
DE (1) DE69315307T2 (sv)
FI (1) FI940503A0 (sv)
GB (2) GB9211796D0 (sv)
IL (1) IL105882A0 (sv)
NZ (1) NZ253230A (sv)
TW (1) TW276252B (sv)
WO (1) WO1993024486A1 (sv)
ZA (1) ZA933644B (sv)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
JPH08504801A (ja) * 1992-12-21 1996-05-28 ゼネカ・リミテッド スクアレンシンターゼ阻害剤としてのキヌクリジン誘導体
US5556990A (en) * 1994-12-16 1996-09-17 Rhone-Poulenc Rorer Pharmaceuticals Inc. Polyarylcarbamoylaza- and -carbamoylalkanedioic acids
US20040186071A1 (en) 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
CA2591439C (en) * 2005-02-22 2013-03-26 Teva Pharmaceutical Industries Ltd. Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof
USRE47320E1 (en) 2007-11-20 2019-03-26 Ionis Pharmaceuticals, Inc. Modulation of CD40 expression

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3405134A (en) * 1965-08-17 1968-10-08 Colgate Palmolive Co Quinuclidyl esters of aromatic acids
NL6715600A (sv) * 1966-12-02 1968-06-04
US3534053A (en) * 1967-05-24 1970-10-13 American Home Prod Quinuclidine derivatives
US3655675A (en) * 1968-09-09 1972-04-11 Sterling Drug Inc N-(n-heteryl)-acylanilides
US3763168A (en) * 1968-09-09 1973-10-02 Sterling Drug Inc N-(3-quinuclidinyl) acylanilides
US3725410A (en) * 1970-07-15 1973-04-03 American Home Prod 3-aminomethyl-3-quinuclidinols
US3679690A (en) * 1971-03-18 1972-07-25 Sterling Drug Inc Certain n-(pyridyl) propionanilides
FR2183565B1 (sv) * 1972-05-10 1975-12-26 Cerm Cent Europ Rech Mauvernay
CA1014958A (en) * 1973-10-05 1977-08-02 Jacques Moleyre .alpha.-QUINUCLIDYLMETHYL PHENYL KETONES
SU495310A1 (ru) * 1974-03-05 1975-12-15 Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени
US4038402A (en) * 1974-03-05 1977-07-26 Mikhail Emmanuilovich Kaminka Method of effecting antihistaminic, antiserotonin and antiallergic actions
FR2414044A1 (fr) * 1978-01-10 1979-08-03 Pharmindustrie Nouveaux derives d'aza-1 bicyclo(2,2,2) octane, utilisables comme medicaments
US4599344A (en) * 1984-10-31 1986-07-08 Schering A.G. Quinuclidines and quinuclidinium salts as antiarrhythmic agents
CH667657A5 (de) * 1985-01-07 1988-10-31 Sandoz Ag Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine.
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
EP0322182A3 (en) * 1987-12-22 1992-01-02 Beecham Group Plc Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
DK730588A (da) * 1988-02-03 1989-08-04 Asta Pharma Ag Anvendelse af pyridin-2-ethere eller pyridin-2-thioethere med en nitrogenholdig cycloalifatisk ring som antidepressivt laegemiddel
NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
US5242914A (en) * 1988-04-01 1993-09-07 Sankyo Company, Limited 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics
ATE114654T1 (de) * 1988-04-01 1994-12-15 Sankyo Co 2-(heterocyclylthio)carbapenemderivate, deren herstellung und deren verwendung als antibiotika.
US5286864A (en) * 1988-11-22 1994-02-15 Boehringer Ingelheim Kg Quinuclidines, their use as medicaments and processes for their preparation
DE8817121U1 (sv) * 1988-11-22 1993-02-04 Boehringer Ingelheim Kg, 6507 Ingelheim, De
GB8918061D0 (en) * 1989-08-08 1989-09-20 Merck Sharp & Dohme Therapeutic agents
YU84791A (sh) * 1990-05-19 1994-06-10 Boehringer Ingelheim Kg. Biciklicni 1-aza-cikloalkalni
DE4116582A1 (de) * 1990-05-19 1991-11-21 Boehringer Ingelheim Kg Bicyclische 1-aza-cycloalkane
ZA92278B (en) * 1991-02-01 1992-10-28 Akzo Nv 3-quinuclidine derivatives
CA2105655A1 (en) * 1991-03-08 1992-09-09 Kent Neuenschwander Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
US5385912A (en) * 1991-03-08 1995-01-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
US5135935A (en) * 1991-05-17 1992-08-04 Merck & Co., Inc. Squalene synthetase inhibitors
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
GB9201749D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Plc Medicaments
GB9202443D0 (en) * 1992-02-05 1992-03-18 Fujisawa Pharmaceutical Co A novel substituted-acetamide compound and a process for the preparation thereof

Also Published As

Publication number Publication date
WO1993024486A1 (en) 1993-12-09
GB9211796D0 (en) 1992-07-15
IL105882A0 (en) 1993-10-20
TW276252B (sv) 1996-05-21
DE69315307D1 (de) 1998-01-02
DE69315307T2 (de) 1998-03-12
GB9310418D0 (en) 1993-07-07
AU670295B2 (en) 1996-07-11
JPH06509590A (ja) 1994-10-27
AU4339893A (en) 1993-12-30
EP0598093B1 (en) 1997-11-19
NZ253230A (en) 1996-06-25
CA2097671A1 (en) 1993-12-05
ATE160348T1 (de) 1997-12-15
FI940503A0 (sv) 1994-02-03
US5554613A (en) 1996-09-10
ZA933644B (en) 1993-12-06
EP0598093A1 (en) 1994-05-25

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