FI935944L - Pyratsolopyrimidin- samt pyrimidinylbisfosfonestrar som anti- inflammatorer - Google Patents

Pyratsolopyrimidin- samt pyrimidinylbisfosfonestrar som anti- inflammatorer Download PDF

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Publication number
FI935944L
FI935944L FI935944A FI935944A FI935944L FI 935944 L FI935944 L FI 935944L FI 935944 A FI935944 A FI 935944A FI 935944 A FI935944 A FI 935944A FI 935944 L FI935944 L FI 935944L
Authority
FI
Finland
Prior art keywords
pyrimidinylbisphosfonestrar
inflammatorer
pyrazolopyrimidin
samt
som
Prior art date
Application number
FI935944A
Other languages
English (en)
Finnish (fi)
Other versions
FI935944A0 (fi
FI935944A7 (fi
Inventor
Richard Allen Nugent
Stephen Thomas Schlachter
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FI935944A0 publication Critical patent/FI935944A0/fi
Publication of FI935944A7 publication Critical patent/FI935944A7/fi
Publication of FI935944L publication Critical patent/FI935944L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
FI935944A 1991-07-03 1992-07-01 Pyratsolopyrimidin- samt pyrimidinylbisfosfonestrar som anti- inflammatorer FI935944L (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72504791A 1991-07-03 1991-07-03
US72504691A 1991-07-03 1991-07-03
PCT/US1992/005398 WO1993001198A1 (en) 1991-07-03 1992-07-01 Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories

Publications (3)

Publication Number Publication Date
FI935944A0 FI935944A0 (fi) 1993-12-30
FI935944A7 FI935944A7 (fi) 1993-12-30
FI935944L true FI935944L (fi) 1993-12-30

Family

ID=27111084

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935944A FI935944L (fi) 1991-07-03 1992-07-01 Pyratsolopyrimidin- samt pyrimidinylbisfosfonestrar som anti- inflammatorer

Country Status (19)

Country Link
US (1) US5397774A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (2) EP0521622B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH06509100A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1031826C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE152728T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU653428B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2110167A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (1) CZ19595A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69219602D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI935944L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (2) HUT70758A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE922162A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL102171A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX9203945A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO940009L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (1) RU2079506C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SK (1) SK277986B6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW222638B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1993001198A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE157097T1 (de) * 1992-08-07 1997-09-15 Upjohn Co Phosphonoessigsäure und ester als antientzündungsmittel
EP0663919A1 (en) * 1992-10-09 1995-07-26 PHARMACIA & UPJOHN COMPANY Pyrimidine bisphosphonate esters as anti-inflamatories
EP0724573A1 (en) * 1993-10-20 1996-08-07 PHARMACIA & UPJOHN COMPANY Pyrimidinones as antiarthritic and anti-inflammatories
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
IT1303672B1 (it) * 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
WO2000038693A1 (fr) * 1998-12-25 2000-07-06 Toray Industries, Inc. Inhibiteurs de la production d'interleukine-6
WO2000059907A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
AU4203500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
RU2183610C1 (ru) * 2000-11-15 2002-06-20 Институт молекулярной генетики РАН Высокомеченный тритием n-[3-(3-цианопиразоло[1,5-а]пиримидин-7-ил)фенил]-n-этилацетамид
AU783516B2 (en) 2001-04-30 2005-11-03 Warner-Lambert Company Methods, kits and compositions for using pyrrole derivatives
US7763624B2 (en) 2005-08-22 2010-07-27 Amgen Inc. Substituted pyrazolo[3,4-d]pyrimidines as ACK-1 and LCK inhibitors
EP2270021A1 (en) 2009-06-18 2011-01-05 Centre National de la Recherche Scientifique Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability
ES2650464T3 (es) * 2011-10-14 2018-01-18 Aktsionernoe Obshcestvo "Proizvodstvenno-Kommercheskaya Assotsiatsiya AZT" Sales de ésteres del ácido carbamoil-fosfónico que actúan como inhibidores selectivos de la producción del virus de la inmunodeficiencia humana VIH-1
JP6632532B2 (ja) * 2014-08-29 2020-01-22 国立大学法人 東京大学 オートタキシン阻害活性を有するピリミジノン誘導体
US10183949B2 (en) 2014-08-29 2019-01-22 The University Of Tokyo Pyrimidinone derivative having autotaxin-inhibitory activity

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
DE2703712A1 (de) * 1977-01-29 1978-08-03 Bayer Ag Substituierte pyrimidinon eckige klammer auf (di)-thio eckige klammer zu -phosphor-(phosphon)-saeureester bzw. -esteramide, verfahren zu ihrer herstellung und ihre verwendung als insektizide, akarizide und nematizide
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
PH27078A (en) * 1984-12-21 1993-02-01 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonates
DE3626058A1 (de) * 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
EP0272208B1 (de) * 1986-11-21 1991-06-12 Ciba-Geigy Ag Aromatisch substituierte Azacyclo-alkylalkandiphosphonsäuren
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
US5071840A (en) * 1986-12-19 1991-12-10 Norwich Eaton Pharmaceuticals, Inc. Certain heterocyclic substituted diphosphonate compounds pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism
DE3719513A1 (de) * 1987-06-11 1988-12-22 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4990503A (en) * 1988-08-12 1991-02-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic bisphosphonic acid derivatives
EP0650360A1 (en) * 1992-07-16 1995-05-03 The Upjohn Company Phosphono derivatives as antiinflammatory and antiarthritic agents
EP0663919A1 (en) * 1992-10-09 1995-07-26 PHARMACIA & UPJOHN COMPANY Pyrimidine bisphosphonate esters as anti-inflamatories

Also Published As

Publication number Publication date
NO940009L (no) 1994-01-09
EP0521622B1 (en) 1997-08-13
FI935944A0 (fi) 1993-12-30
CN1031826C (zh) 1996-05-22
HU9400003D0 (en) 1994-05-30
FI935944A7 (fi) 1993-12-30
EP0521622A1 (en) 1993-01-07
ATE152728T1 (de) 1997-05-15
IL102171A (en) 1996-11-14
HU211488A9 (en) 1995-11-28
DE69219602D1 (de) 1997-06-12
WO1993001198A1 (en) 1993-01-21
CN1068332A (zh) 1993-01-27
EP0593575A1 (en) 1994-04-27
AU2240892A (en) 1993-02-11
EP0593575B1 (en) 1997-05-07
CA2110167A1 (en) 1993-01-21
IL102171A0 (en) 1993-01-14
HUT70758A (en) 1995-10-30
CZ19595A3 (en) 1995-10-18
MX9203945A (es) 1993-04-01
US5397774A (en) 1995-03-14
NO940009D0 (no) 1994-01-03
TW222638B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1994-04-21
AU653428B2 (en) 1994-09-29
JPH06509100A (ja) 1994-10-13
SK277986B6 (en) 1995-09-13
SK150493A3 (en) 1994-11-09
RU2079506C1 (ru) 1997-05-20
IE922162A1 (en) 1993-01-13

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Legal Events

Date Code Title Description
HC Name/ company changed in application

Owner name: PHARMACIA & UPJOHN COMPANY

FD Application lapsed