FI935074A0 - Nya tiopyranopyrrolderivat och framstaellning av dem - Google Patents

Nya tiopyranopyrrolderivat och framstaellning av dem

Info

Publication number
FI935074A0
FI935074A0 FI935074A FI935074A FI935074A0 FI 935074 A0 FI935074 A0 FI 935074A0 FI 935074 A FI935074 A FI 935074A FI 935074 A FI935074 A FI 935074A FI 935074 A0 FI935074 A0 FI 935074A0
Authority
FI
Finland
Prior art keywords
thiopyranopyrrole
framed
dem
Prior art date
Application number
FI935074A
Other languages
English (en)
Other versions
FI935074A (fi
Inventor
Daniel Achard
Claude Moutonnier
Jean-Francois Peyronel
Michel Tabart
Alain Truchon
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of FI935074A0 publication Critical patent/FI935074A0/fi
Publication of FI935074A publication Critical patent/FI935074A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI935074A 1991-05-17 1993-11-16 Nya tiopyranopyrrolderivat och framstaellning av dem FI935074A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9106038A FR2676447B1 (fr) 1991-05-17 1991-05-17 Nouveaux derives du thiopyranopyrrole et leur preparation.
PCT/FR1992/000432 WO1992020686A1 (fr) 1991-05-17 1992-05-15 Nouveaux derives du thiopyranopyrrole et leur preparation

Publications (2)

Publication Number Publication Date
FI935074A0 true FI935074A0 (fi) 1993-11-16
FI935074A FI935074A (fi) 1993-11-16

Family

ID=9412910

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935074A FI935074A (fi) 1991-05-17 1993-11-16 Nya tiopyranopyrrolderivat och framstaellning av dem

Country Status (18)

Country Link
US (1) US5484942A (fi)
EP (2) EP0514276A1 (fi)
JP (1) JPH06507895A (fi)
AU (1) AU653032B2 (fi)
CA (1) CA2109295A1 (fi)
CZ (1) CZ245093A3 (fi)
FI (1) FI935074A (fi)
FR (1) FR2676447B1 (fi)
HU (1) HUT65590A (fi)
IE (1) IE921544A1 (fi)
IL (1) IL101865A0 (fi)
MX (1) MX9202290A (fi)
NO (1) NO933690L (fi)
NZ (1) NZ242738A (fi)
SK (1) SK126693A3 (fi)
WO (1) WO1992020686A1 (fi)
YU (1) YU51092A (fi)
ZA (1) ZA923516B (fi)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676446B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux derives du thiopyranopyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
ES2304984T3 (es) 1999-11-03 2008-11-01 Amr Technology, Inc. Tetra-hidroisoquinolinas de sustitucion arilica y heteroarilica y su utilizacion para bloquear la recaptacion de norepinefrina, dopamina y serotonina.
EP1299393A2 (en) 2000-07-11 2003-04-09 Bristol-Myers Squibb Pharma Company 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
NZ552397A (en) 2004-07-15 2011-04-29 Amr Technology Inc Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
ATE550019T1 (de) 2005-05-17 2012-04-15 Merck Sharp & Dohme Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
KR101589551B1 (ko) 2005-07-15 2016-02-02 알바니 몰레큘라 리써치, 인크. 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
PL2109608T3 (pl) 2007-01-10 2011-08-31 Msd Italia Srl Indazole podstawione grupą amidową jako inhibitory polimerazy poli(ADP-rybozy)-(PARP)
CA2690191C (en) 2007-06-27 2015-07-28 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
AU2010247735B2 (en) 2009-05-12 2015-07-16 Albany Molecular Research, Inc. Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof
US8802696B2 (en) 2009-05-12 2014-08-12 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoqu inoli and use thereof
KR20120034644A (ko) 2009-05-12 2012-04-12 알바니 몰레큘라 리써치, 인크. 아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도
BR112012008849A2 (pt) 2009-10-14 2015-09-22 Schering Corp composto, composição farmacêutica, e, uso de um composto
CN103068980B (zh) 2010-08-02 2017-04-05 瑟纳治疗公司 使用短干扰核酸（siNA）的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1（CTNNB1）基因表达的抑制
SI2606134T1 (sl) 2010-08-17 2019-08-30 Sirna Therapeutics, Inc. RNA-INTERFERENČNO POSREDOVANO ZAVIRANJE IZRAŽANJA GENA VIRUSA HEPATITISA B (HBV) Z UPORABO KRATKE INTERFERENČNE NUKLEINSKE KISLINE (siNA)
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
WO2012030685A2 (en) 2010-09-01 2012-03-08 Schering Corporation Indazole derivatives useful as erk inhibitors
EP2615916B1 (en) 2010-09-16 2017-01-04 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel erk inhibitors
DK2632472T3 (en) 2010-10-29 2018-03-19 Sirna Therapeutics Inc RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA)
WO2012087772A1 (en) 2010-12-21 2012-06-28 Schering Corporation Indazole derivatives useful as erk inhibitors
IN2013MN02170A (fi) 2011-04-21 2015-06-12 Piramal Entpr Ltd
EP2770987B1 (en) 2011-10-27 2018-04-04 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
EP3919620A1 (en) 2012-05-02 2021-12-08 Sirna Therapeutics, Inc. Short interfering nucleic acid (sina) compositions
JP6280554B2 (ja) 2012-09-28 2018-02-14 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｅｒｋ阻害剤である新規化合物
PL2925888T3 (pl) 2012-11-28 2018-03-30 Merck Sharp & Dohme Corp. Kompozycje i sposoby do stosowania w leczeniu nowotworów
WO2014100065A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
US10975084B2 (en) 2016-10-12 2021-04-13 Merck Sharp & Dohme Corp. KDM5 inhibitors
US10947234B2 (en) 2017-11-08 2021-03-16 Merck Sharp & Dohme Corp. PRMT5 inhibitors
US11993602B2 (en) 2018-08-07 2024-05-28 Merck Sharp & Dohme Llc PRMT5 inhibitors
WO2020033284A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042707A (en) * 1976-02-19 1977-08-16 E. I. Du Pont De Nemours And Company 3α-Arylhydroisoindoles
AU502760B2 (en) * 1977-02-28 1979-08-09 Science Union Et Cie, Societe Francaise De Recherche Medicale Azabicycloalkanes and their preparation
EP0093805B1 (en) * 1981-02-17 1987-05-13 Warner-Lambert Company Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1h-isoindole-1-carboxylic acids and esters
US4439229A (en) * 1981-06-29 1984-03-27 Rohm And Haas Company Substituted phthalimides herbicides
US4503043A (en) * 1981-12-07 1985-03-05 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids
JPH0278659A (ja) * 1988-09-12 1990-03-19 Shionogi & Co Ltd アザビシクロアルカン類化合物
FR2676446B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux derives du thiopyranopyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
NO933690D0 (no) 1993-10-13
ZA923516B (en) 1993-02-24
US5484942A (en) 1996-01-16
HU9303251D0 (en) 1994-03-28
NZ242738A (en) 1994-07-26
NO933690L (no) 1993-10-13
HUT65590A (en) 1994-07-28
FR2676447A1 (fr) 1992-11-20
WO1992020686A1 (fr) 1992-11-26
CZ245093A3 (en) 1994-03-16
EP0514276A1 (fr) 1992-11-19
IE921544A1 (en) 1992-11-18
FI935074A (fi) 1993-11-16
AU653032B2 (en) 1994-09-15
MX9202290A (es) 1993-02-01
FR2676447B1 (fr) 1993-08-06
EP0587673A1 (fr) 1994-03-23
IL101865A0 (en) 1992-12-30
SK126693A3 (en) 1994-05-11
JPH06507895A (ja) 1994-09-08
AU1913792A (en) 1992-12-30
CA2109295A1 (fr) 1992-11-18
YU51092A (sh) 1994-06-10

Similar Documents

Publication Publication Date Title
FI935074A0 (fi) Nya tiopyranopyrrolderivat och framstaellning av dem
FI934361A (fi) Foerfarande och anordning foer evaluering av vaegningsparametrarna foer en signal i en mottagare
FI933418A (fi) Foerfarande foer defibrering av lignocellulosamaterial och aotervinning av biprodukter
FI922564A (fi) Foerfarande foer bestaemning av utjaemningsfoerdroejningar i oeverfoeringssystem och motsvarande oeverfoeringssystem
FI923019A (fi) Avloppsventil foer en dieselbraennkraftmaskin och foerfarande foer framstaellning av ventilen
FI920396A (fi) Foerfarande foer reglering av en reaktiv sputteringsprocess och anordning foer utfoerande av foerfarandet
FI925784A0 (fi) Diaram och tillverkningsfoerfarande av densamma
FI935190A0 (fi) Foerfarande och anordning foer bestaemning av totala stroemningen i en ventilationsinstallation
FI921284A (fi) Framstaellnin av styva skum och komposition anvaendbar daeri
FI922051A (fi) Foerfarande och anordning foer anvaendning av enzymer vid framstaellning och blekning av pappersmassa
FI913985A (fi) Brandbegraensare och foerfarande foer laosning av tillslutningsorganet av brandbegraensaren
FI923399A (fi) Foerfarande och anordning foer minskande av kvaeveoksidutslaepp av foerbraenningsmotorer
FI933977A0 (fi) Blekningsfoerfarande foer kemisk pappersmassa och tilllaempning av detta foerfarande vid blekning av kraftmassa
FI924549A (fi) Tvaettkomposition och testanordning och -metod foer bestaemning av mikroorganismer foerknipade med tandsjukdomar
FI933376A0 (fi) 4-amino-3-acylkinolinderivater och deras anvaendning som inhibitorer avmagsyrasekretion
FI932863A0 (fi) Foerfarande foer framstaellning av nya tienotiazinderivat och deras anvaendning
FI913816A (fi) Foerfarande och arrangemang foer starning av foerbraenningsmotor
FI933198A (fi) Flytbaeddsbraennkammare med anordningar foer foerbaettring av foerdelning avbraensle och gaser
FI924139A (fi) Skumhindrande/skumreducerande komposition och foerfarande foer anvaendning av denna i vattenhaltiga system
FI924860A (fi) Anordning foer skyddande och/eller anvaendning av borrskaer
FI923125A (fi) Foerfarande foer stabilisering av dibenzylidensorbitoler och sammansaettning daerav
FI922485A (fi) Elektrokemiskt foerfarande och anordning foer avlaegsnande av syre ur vatten eller vattenloesningar
FI922026A (fi) Anordning foer sortering och rengoering av pappersmaterial
FI930344A0 (fi) Smoerjmedel foer tvaotaktsmotor och foerfarande foer anvaendning av detsamma
FI924986A0 (fi) Nya dietylentriaminderivat och anvaendning av dessa foer diagnostiska och terapeutiska aendamaol