FI92828B - Förfarande för framställning av terapeutiskt värdefullt 5,11-dihydro-6H-dipyrido/3,2-b:2',3'-e/ /1,4/diazepin-6-on - Google Patents

Förfarande för framställning av terapeutiskt värdefullt 5,11-dihydro-6H-dipyrido/3,2-b:2',3'-e/ /1,4/diazepin-6-on Download PDF

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Publication number
FI92828B
FI92828B FI903225A FI903225A FI92828B FI 92828 B FI92828 B FI 92828B FI 903225 A FI903225 A FI 903225A FI 903225 A FI903225 A FI 903225A FI 92828 B FI92828 B FI 92828B
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FI
Finland
Prior art keywords
formula
alkyl
compound
group
hydrogen
Prior art date
Application number
FI903225A
Other languages
English (en)
Finnish (fi)
Other versions
FI92828C (sv
FI903225A0 (sv
Inventor
Wolfgang Eberlein
Wolfhard Engel
Guenter Trummlitz
Karl D Hargrave
Margaret Schmidt
Original Assignee
Thomae Gmbh Dr K
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K, Boehringer Ingelheim Pharma filed Critical Thomae Gmbh Dr K
Publication of FI903225A0 publication Critical patent/FI903225A0/sv
Application granted granted Critical
Publication of FI92828B publication Critical patent/FI92828B/sv
Publication of FI92828C publication Critical patent/FI92828C/sv

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI903225A 1989-06-28 1990-06-27 Förfarande för framställning av terapeutiskt värdefullt 5,11-dihydro-6H-dipyrido/3,2-b:2',3'-e/ /1,4/diazepin-6-on FI92828C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37297489A 1989-06-28 1989-06-28
US37297489 1989-06-28

Publications (3)

Publication Number Publication Date
FI903225A0 FI903225A0 (sv) 1990-06-27
FI92828B true FI92828B (sv) 1994-09-30
FI92828C FI92828C (sv) 1995-01-10

Family

ID=23470402

Family Applications (1)

Application Number Title Priority Date Filing Date
FI903225A FI92828C (sv) 1989-06-28 1990-06-27 Förfarande för framställning av terapeutiskt värdefullt 5,11-dihydro-6H-dipyrido/3,2-b:2',3'-e/ /1,4/diazepin-6-on

Country Status (21)

Country Link
EP (1) EP0410148B1 (sv)
JP (1) JP2911967B2 (sv)
KR (1) KR0160285B1 (sv)
AP (1) AP189A (sv)
AT (1) ATE103918T1 (sv)
AU (1) AU620724B2 (sv)
CA (1) CA2019812C (sv)
DD (1) DD295849A5 (sv)
DE (1) DE69007891T2 (sv)
DK (1) DK0410148T3 (sv)
ES (1) ES2063202T3 (sv)
FI (1) FI92828C (sv)
HU (1) HU206504B (sv)
IE (1) IE65247B1 (sv)
IL (1) IL94883A (sv)
NO (1) NO174468B (sv)
NZ (1) NZ234261A (sv)
OA (1) OA09741A (sv)
PT (1) PT94521B (sv)
RU (1) RU2024522C1 (sv)
ZA (1) ZA904991B (sv)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3802334A1 (de) * 1988-01-27 1989-08-10 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
CA2030056C (en) * 1989-11-17 1995-10-17 Karl D. Hargrave 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection
JP2912007B2 (ja) * 1989-11-17 1999-06-28 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレーテッド ５，１１―ジヒドロ―６Ｈ―ジピリド〔３，２―ｂ：２′，３′―ｅ〕〔１，４〕ジアゼピンおよび該化合物を含有するＨＩＶ感染の予防又は治療用組成物
CA2052946A1 (en) * 1990-10-19 1992-04-20 Karl G. Grozinger Method for the preparation of 5,11-dihydro-6h-dipyrido ¬3,2-b:2', 3'-e| ¬1,4|diazepines
EP0498290B1 (en) * 1991-02-07 1996-09-18 Boehringer Ingelheim Pharmaceuticals Inc. Pyridobenzodiazepines, dipyrido [3,2-b:2',3'-e] [1,4]diazepines and their use in the prevention or treatment of HIV infection
DE4403311C1 (de) * 1994-02-03 1995-04-20 Boehringer Ingelheim Kg Verfahren zur Herstellung von Nevirapine (11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4-diazepin]-6-on)
AU690646B2 (en) * 1994-02-18 1998-04-30 Boehringer Ingelheim Pharmaceuticals, Inc. 2-heteroaryl-5,11-dihydro-6H-dipyrido(3,2-b:2',3'-e)(1 ,4)diazepines and their use in the prevention or treatment of HIV infection
US5747488A (en) * 1996-01-30 1998-05-05 Boehringer Ingelheim Pharmaceuticals, Inc. 2-aryl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-E! 1, 4!diazepines and their use in the treatment of HIV infection
DE10023492A1 (de) * 2000-05-09 2001-11-22 Schering Ag Aza- und Polyazanthranylamide und deren Verwendung als Arzneimittel
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
US7307088B2 (en) 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
US8247556B2 (en) 2005-10-21 2012-08-21 Amgen Inc. Method for preparing 6-substituted-7-aza-indoles
KR101194036B1 (ko) 2010-08-18 2012-10-24 한국에너지기술연구원 태양에너지를 활용한 유체가열장치
TW201632520A (zh) 2014-11-25 2016-09-16 拜耳製藥股份有限公司 經取代之吡啶並苯並二氮呯酮衍生物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA835391A (en) * 1970-02-24 Schmidt Gunther 5,6-dihydro-5-oxo-11h-pyrido (2,3-6) (1,5) benzodiazepine compounds
CA783570A (en) * 1968-04-23 Schmidt Gunther 5,6-dihydro-6-oxo-11h-pyrido (2,3-b) (1,4)-benzodiazepines
CA554134A (en) * 1958-03-11 Hoffmann Karl Thia-aza-cycloheptadiene compounds and process for their manufacture
CA658624A (en) * 1963-02-26 Schmutz Jean Diazepine derivatives
NL131929C (sv) * 1966-10-31
GB1262864A (en) * 1968-03-29 1972-02-09 Glaxo Lab Ltd Diazacarbazoles
DE3122670A1 (de) * 1981-06-06 1982-12-23 Dr. Karl Thomae Gmbh, 7950 Biberach "neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen"
DE3726908A1 (de) * 1987-08-13 1989-02-23 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3735895A1 (de) * 1987-10-23 1989-05-03 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3820346A1 (de) * 1988-06-15 1989-12-21 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3820345A1 (de) * 1988-06-15 1989-12-21 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
KR910000727A (ko) 1991-01-30
KR0160285B1 (ko) 1998-12-01
FI92828C (sv) 1995-01-10
AU5792190A (en) 1991-01-03
IE902322L (en) 1990-12-28
DE69007891D1 (de) 1994-05-11
ZA904991B (en) 1992-03-25
HU206504B (en) 1992-11-30
NO902851L (no) 1991-01-02
FI903225A0 (sv) 1990-06-27
EP0410148A1 (en) 1991-01-30
DD295849A5 (de) 1991-11-14
RU2024522C1 (ru) 1994-12-15
JP2911967B2 (ja) 1999-06-28
NO174468B (no) 1994-01-31
IE65247B1 (en) 1995-10-18
ES2063202T3 (es) 1995-01-01
NO902851D0 (no) 1990-06-27
DK0410148T3 (da) 1994-08-08
ATE103918T1 (de) 1994-04-15
HU904021D0 (en) 1990-12-28
EP0410148B1 (en) 1994-04-06
PT94521A (pt) 1991-02-08
PT94521B (pt) 1997-02-28
JPH03115283A (ja) 1991-05-16
AP9000188A0 (en) 1990-07-31
DE69007891T2 (de) 1994-08-25
NO174468C (sv) 1994-05-18
IL94883A (en) 1994-10-07
NZ234261A (en) 1992-11-25
AU620724B2 (en) 1992-02-20
HUT55017A (en) 1991-04-29
AP189A (en) 1992-05-04
CA2019812A1 (en) 1990-12-28
IL94883A0 (en) 1991-04-15
OA09741A (en) 1993-11-30
IE902322A1 (en) 1991-01-16
CA2019812C (en) 2000-11-21

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Date Code Title Description
BB Publication of examined application
FG Patent granted

Owner name: DR. KARL THOMAE GESELLSCHAFT MIT

Owner name: BOEHRINGER INGELHEIM PHARMACEUTICALS INC