FI925946A7 - Uusia 2-sakkarinyylimetyyliaryyli- ja -aryylioksiasetaatteja, jotka ovat käyttökelpoisia proteolyyttisten entsyymien inhibiittoreina, niitä sisältäviä koostumuksia ja niiden käyttö - Google Patents

Uusia 2-sakkarinyylimetyyliaryyli- ja -aryylioksiasetaatteja, jotka ovat käyttökelpoisia proteolyyttisten entsyymien inhibiittoreina, niitä sisältäviä koostumuksia ja niiden käyttö Download PDF

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Publication number
FI925946A7
FI925946A7 FI925946A FI925946A FI925946A7 FI 925946 A7 FI925946 A7 FI 925946A7 FI 925946 A FI925946 A FI 925946A FI 925946 A FI925946 A FI 925946A FI 925946 A7 FI925946 A7 FI 925946A7
Authority
FI
Finland
Prior art keywords
aryloxyacetates
inhibitors
novel
useful
compositions containing
Prior art date
Application number
FI925946A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI925946L (fi
FI925946A0 (fi
Inventor
Richard Paul Dunlap
Lee Hamilton Latimer
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of FI925946A0 publication Critical patent/FI925946A0/fi
Publication of FI925946L publication Critical patent/FI925946L/fi
Publication of FI925946A7 publication Critical patent/FI925946A7/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI925946A 1991-12-30 1992-12-30 Uusia 2-sakkarinyylimetyyliaryyli- ja -aryylioksiasetaatteja, jotka ovat käyttökelpoisia proteolyyttisten entsyymien inhibiittoreina, niitä sisältäviä koostumuksia ja niiden käyttö FI925946A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81574091A 1991-12-30 1991-12-30

Publications (3)

Publication Number Publication Date
FI925946A0 FI925946A0 (fi) 1992-12-30
FI925946L FI925946L (fi) 1993-07-01
FI925946A7 true FI925946A7 (fi) 1993-07-01

Family

ID=25218721

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925946A FI925946A7 (fi) 1991-12-30 1992-12-30 Uusia 2-sakkarinyylimetyyliaryyli- ja -aryylioksiasetaatteja, jotka ovat käyttökelpoisia proteolyyttisten entsyymien inhibiittoreina, niitä sisältäviä koostumuksia ja niiden käyttö

Country Status (17)

Country Link
US (3) US5385923A (enFirst)
EP (1) EP0550112A1 (enFirst)
JP (1) JPH05255286A (enFirst)
AU (1) AU651746B2 (enFirst)
CA (1) CA2086348A1 (enFirst)
CZ (1) CZ386992A3 (enFirst)
FI (1) FI925946A7 (enFirst)
HU (2) HUT65736A (enFirst)
IL (1) IL104259A (enFirst)
MX (1) MX9207274A (enFirst)
MY (1) MY108926A (enFirst)
NO (1) NO303446B1 (enFirst)
NZ (1) NZ245586A (enFirst)
PH (1) PH30411A (enFirst)
RU (1) RU2081871C1 (enFirst)
SG (1) SG48025A1 (enFirst)
TW (1) TW226016B (enFirst)

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US5380737A (en) * 1989-05-04 1995-01-10 Sterling Winthrop Inc. Saccharin derivative proteolytic enzyme inhibitors
US5306818A (en) * 1990-11-01 1994-04-26 Sterling Winthrop Inc. Tetrahydro 2-saccharinylmerthyl aryl carboxylates
DE19533643A1 (de) * 1995-09-12 1997-03-13 Nycomed Arzneimittel Gmbh Neue cyclische Derivate von Benzolsulfonamiden
DE19748470A1 (de) * 1997-11-03 1999-05-06 Hoechst Schering Agrevo Gmbh Carbamoylphenylsulfonylharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und Pflanzenwachstumsregulatoren
US20090053221A1 (en) * 2006-01-17 2009-02-26 Cheung Nai-Kong V Immune response enhancing glucan
PT2445502T (pt) 2009-06-25 2017-09-22 Alkermes Pharma Ireland Ltd Compostos heterocíclicos para o tratamento de distúrbios neurológicos e psicológicos
JP5732453B2 (ja) 2009-06-25 2015-06-10 アルカーメス ファーマ アイルランド リミテッド Ｎｈ酸性化合物のプロドラッグ
EP2521711B1 (en) * 2010-01-07 2017-08-16 Alkermes Pharma Ireland Limited Quaternary ammonium salt prodrugs
NZ604423A (en) 2010-06-24 2015-01-30 Alkermes Pharma Ireland Ltd Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
ES2972387T3 (es) 2011-03-18 2024-06-12 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden ésteres de sorbitán
WO2013088255A1 (en) 2011-12-15 2013-06-20 Alkermes Pharma Ireland Limited Prodrugs of secondary amine compounds
CA2867121C (en) 2012-03-19 2021-05-25 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising fatty acid esters
WO2013142202A1 (en) 2012-03-19 2013-09-26 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising glycerol esters
US9999670B2 (en) 2012-03-19 2018-06-19 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising benzyl alcohol
JP6654042B2 (ja) 2012-09-19 2020-02-26 アルカームス ファーマ アイルランド リミテッド 貯蔵安定性が改善された医薬組成物
WO2015102992A1 (en) 2013-12-31 2015-07-09 Saint-Gobain Abrasives, Inc. Abrasive article including shaped abrasive particles
US20150253127A1 (en) * 2014-03-04 2015-09-10 Honeywell Asca Inc. Thickness Determination of Web Product by Mid-infrared Wavelength Scanning Interferometry
AU2015231278B2 (en) 2014-03-20 2020-01-23 Alkermes Pharma Ireland Limited Aripiprazole formulations having increased injection speeds
US10346168B2 (en) 2015-06-26 2019-07-09 Microsoft Technology Licensing, Llc Decoupled processor instruction window and operand buffer
AU2019230014B2 (en) 2018-03-05 2024-11-28 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy

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US3002884A (en) * 1959-04-15 1961-10-03 Rohm & Haas Horticultural process with n-halomethyl-1,2-benzisothiazolin - 3 - one-1,1-dioxides for controlling fungus diseases
US3314960A (en) * 1964-08-25 1967-04-18 American Home Prod Benzisothiazol glutarimides
FR1451417A (fr) * 1965-07-15 1966-01-07 Roussel Uclaf Nouveaux esters d'acides cycliques et leur procédé de préparation
JPS4835457A (enFirst) * 1971-09-02 1973-05-24
US4195023A (en) * 1975-08-20 1980-03-25 Merck & Co., Inc. 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin
US4276298A (en) * 1978-03-24 1981-06-30 Merck & Co., Inc. 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors
US4263393A (en) * 1979-09-06 1981-04-21 Eastman Kodak Company Novel electron donor precursors and photographic element containing them
US4350752A (en) * 1980-12-29 1982-09-21 Eastman Kodak Company Photographic elements and film units containing imidomethyl blocked photographic reagents
US4363865A (en) * 1981-03-04 1982-12-14 Eastman Kodak Company Imido methyl blocked photographic dyes and dye releasing compounds
US4410618A (en) * 1982-06-11 1983-10-18 Eastman Kodak Company Blocked photographic reagents
US4547371A (en) * 1983-04-18 1985-10-15 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
US4623645A (en) * 1983-04-18 1986-11-18 Merck & Co., Inc. Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents
US4659855A (en) * 1983-05-09 1987-04-21 Georgia Tech Research Corporation Aryl sulfonyl fluoride compounds
DE3617976A1 (de) * 1986-05-28 1988-01-14 Alter Sa 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten
EP0253029A1 (en) * 1986-07-10 1988-01-20 Keng-Ben Wang A distilled drinking water fountain
US5128339A (en) * 1990-11-01 1992-07-07 Sterling Winthrop Inc. Proteolytic enzyme inhibition method
KR0183397B1 (ko) * 1989-05-04 1999-05-01 존 엠. 스피나토 단백질 분해 효소 저해제로서 유용한 사카린 유도체들 및 그의 제조방법
FR2659327A1 (fr) * 1990-03-08 1991-09-13 Centre Nat Rech Scient Derives du benzisothiazolinone-1-dioxyde, utilisables comme inhibiteurs des elastases.
AU642537B2 (en) * 1990-11-01 1993-10-21 Sanofi 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5279758A (en) * 1991-10-22 1994-01-18 The Clorox Company Thickened aqueous cleaning compositions
AU656027B2 (en) * 1991-11-15 1995-01-19 Sanofi Saccharin derivative proteolytic enzime inhibitors
AU653279B2 (en) * 1991-12-30 1994-09-22 Sanofi Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
JPH07200419A (ja) * 1993-12-28 1995-08-04 Nec Corp バスインタフェース装置
DE4420271B4 (de) * 1994-06-10 2007-09-27 Robert Bosch Gmbh Zündspulensatz für eine Mehrzylinder-Brennkraftmaschine

Also Published As

Publication number Publication date
US5489604A (en) 1996-02-06
MX9207274A (es) 1993-06-01
US5783589A (en) 1998-07-21
PH30411A (en) 1997-05-09
US5385923A (en) 1995-01-31
NZ245586A (en) 1994-11-25
FI925946L (fi) 1993-07-01
AU2966992A (en) 1993-07-01
SG48025A1 (en) 1998-04-17
FI925946A0 (fi) 1992-12-30
CA2086348A1 (en) 1993-07-01
HU9204166D0 (en) 1993-04-28
CZ386992A3 (en) 1993-09-15
IL104259A0 (en) 1993-05-13
NO925041D0 (no) 1992-12-30
NO303446B1 (no) 1998-07-13
RU2081871C1 (ru) 1997-06-20
TW226016B (enFirst) 1994-07-01
HU211625A9 (en) 1995-12-28
EP0550112A1 (en) 1993-07-07
AU651746B2 (en) 1994-07-28
MY108926A (en) 1996-11-30
JPH05255286A (ja) 1993-10-05
HUT65736A (en) 1994-07-28
NO925041L (no) 1993-07-01
IL104259A (en) 1997-09-30

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